塩化ベンゼンの生体膜に対する作用 第Ⅳ報 分離正常ラット肝ミトコンドリアにおける塩化ベンゼン及び塩化フェノールの作用の比較

A comparative study on the effect of chlorobenzenes and chlorophenols on mitochondrial membranes was conducted. An increase in chlorine residue from both chlorobenzenes and chlorophenols caused a decrease in respiratory control index (RCI). Chlorophenols acted on biomembranes at a lower concentration than chlorobenzenes. The compounds decreased RCI by increasing state 4 respiration and decreasing state 3 respiration. As the number of chlorine atoms on chlorobenzenes increased, state 3 respiration decreased, causing a decrease in RCI. As the number of chlorine atoms on chlorophenols increased, state 4 respiration increased, causing a decreased in RCI. The amount of potassium released from mitochondrial membranes increased with time after addition of dichlorobenzene and dichlorophenol. A logarithmic increase in potassium release vs. time was observed with dichlorobenzene, and a liner increase in potassium release was observed with dichlorophenol.