| ID | 16441 |
| Eprint ID | 16441
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| FullText URL | |
| Title Alternative | Studies on the biological toxicity several brominated benzene pollutants of the environment Report 5. Metabolism of 1.3.5-tribromobenzene
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| Author |
Ogino, Yasuo
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| Abstract | The formative mechanism of debrominated compounds was investigeted. The excretion rate of tribromobenzene metabolites into the rat urine was enhanced by pretreatment with phenobarbital, and the amount of debrominated bromophenol in urine was greater than that of sulfur containing compounds after phenobarbital pretreatment. on the other hand, sulfur containing compounds were predominant in the urine of rats pretreated with glutathione. Incubation of tribromobenzene with the 10,000g supernatant of rat liver homogenate from rats pretreated with phenobarbital resulted in an increase in 3.5-dibromophenol. The above effect was accelerated remarkably by NADH and NADPH. These results demonstrate two metabolic pathways in the debromination of tribromobenzene: one to sulfur containing compounds and another to bromophenol bodies.
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| Keywords | 1.3.5-トリブロモベンゼン
代謝経路
脱ブロモ化
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| Published Date | 1984-04-30
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume96
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| Issue | issue5-6
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 579
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| End Page | 584
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/96/5-6/96_5-6_579/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
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