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Detection of Identical Isolates of Enterococcus faecalis from the Blood and Oral Mucosa in a Patient with Infective Endocarditis
Author Okui, Akemi| Soga, Yoshihiko| Kokeguchi, Susumu| Nose, Motoko| Yamanaka, Reiko| Kusano, Nobuchika| Morita, Manabu|
Published Date 2015-07-15
Publication Title Internal Medicine
Volume volume54
Issue issue14
Content Type Journal Article
Neoadjuvant Chemotherapy with or without Concurrent Hormone Therapy in Estrogen Receptor-Positive Breast Cancer:NACED-Randomized Multicenter Phase II Trial
JaLCDOI 10.18926/AMO/53675
FullText URL 69_5_291.pdf
Author Sugiu, Kumi| Iwamoto, Takayuki| Kelly, Catherine M.| Watanabe, Naoki| Motoki, Takayuki| Itoh, Mitsuya| Ohtani, Shoichiro| Higaki, Kenji| Imada, Takako| Yuasa, Takeshi| Omori, Masako| Sonobe, Hiroshi| Fujiwara, Toshiyoshi| Matsuoka, Junji|
Abstract Although in the neoadjuvant setting for estrogen receptor (ER)-positive breast cancers, chemotherapy or hormone therapy alone does not result in satisfactory tumor response, it is unknown whether concurrent chemo-endocrine therapy is superior to chemotherapy alone in clinical outcomes. We conducted a randomized phase II trial to test the responses of ER-positive patients to concurrent administration of chemo-endocrine therapy in the neoadjuvant setting. Women with stage II-III, ER-positive, invasive breast cancer (n=28) received paclitaxel followed by fluorouracil, epirubicin, cyclophosphamide (T-FEC) and were randomized to receive concurrent chemo-endocrine therapy consisting of goserelin administered subcutaneously for premenopausal women or an aromatase inhibitor for postmenopausal women. The primary endpoint was the pathological complete response (pCR) rate after neoadjuvant therapy. Twenty-eight patients were randomized. There were no significant differences in pCR rate between the concurrent group (12.5%;2/16) and the chemotherapy alone group (8.3%;1/12). Tumor size after therapy was significantly reduced in the concurrent therapy group (p=0.035), but not in the chemotherapy-alone group (p=0.622). Neoadjuvant chemotherapy with concurrent hormone therapy provided no significant improvement in pCR rate in ER-positive breast cancers. These preliminary results should be followed up by further studies.
Keywords breast cancer neoadjuvant chemotherapy concurrent hormone therapy estrogen receptor positive tumor response
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-10
Volume volume69
Issue issue5
Publisher Okayama University Medical School
Start Page 291
End Page 299
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26490026
Web of Science KeyUT 000365519600005
The cyclic GMP-AMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly
Author Dansako, Hiromichi| Ueda, Youki| Okumura, Nobuaki| Satoh, Shinya| Sugiyama, Masaya| Mizokami, Masashi| Ikeda, Masanori| Kato, Nobuyuki|
Published Date 2015
Publication Title The FEBS journal
Content Type Journal Article
ARID1A expression in gastric adenocarcinoma: Clinicopathological significance and correlation with DNA mismatch repair status
FullText URL K0005202_abstract_review.pdf K0005202_fulltext.pdf
Author Inada, Ryo|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5202号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Effectiveness of Extending Treatment Duration in Therapy with Pegylated Interferon and Ribavirin for Genotype 2 Hepatitis C Virus Infection
FullText URL K0005201_abstract_review.pdf K0005201_fulltext.pdf
Author Nanba, Shintarou|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5201号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Hemodynamic Effects of Intravenous Calcium Administration on Septic Shock Patients: A Retrospective Study
FullText URL K0005200_abstract_review.pdf K0005200_fulltext.pdf
Author Ishibashi, Naoki|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5200号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Intraoperative change of lactate level is associated with postoperative outcomes in pediatric cardiac surgery patients: retrospective observational study
FullText URL K0005199_abstract_review.pdf K0005199_fulltext.pdf K0005199_fulltext_other.pdf
Author Kanazawa, Tomoyuki|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5199号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Hyaluronan suppresses mechanical stress-induced expression of catabolic enzymes by human chondrocytes via inhibition of IL-1β production and subsequent NF-κB activation
FullText URL K0005198_abstract_review.pdf K0005198_fulltext.pdf
Author Ozawa, Masatsugu|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5198号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Venous Thromboembolism after Total Hip Arthroplasty Diagnosed by Enhanced Computed Tomography: Comparison of Selective Thromboprophylaxis and No Thromboprophylaxis
FullText URL K0005197_abstract_review.pdf K0005197_fulltext.pdf
Author Okada, Yoshiki|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5197号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Establishment of a pancreatic stem cell line from fibroblast-derived induced pluripotent stem cells
FullText URL K0005196_abstract_review.pdf K0005196_fulltext.pdf K0005196_fulltext_other.pdf
Author Kuise, Takashi|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5196号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Comparison of Field-in-Field Radiotherapy with Conformal Radiotherapy for Unilateral Cervical Malignant Lymphoma
FullText URL K0005195_abstract_review.pdf K0005195_fulltext.pdf
Author Yamashita, Mako|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5195号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
The urinary levels of prostanoid metabolites predict acute kidney injury in heterogeneous adult Japanese ICU patients: a prospective observational study
FullText URL K0005194_abstract_review.pdf K0005194_summary.pdf K0005194_fulltext.pdf
Author Omori, Haruyo|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5194号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Analysis of risk factors for colonic diverticular bleeding: A matched case–control study
FullText URL K0005193_abstract_review.pdf K0005193_fulltext.pdf K0005193_fulltext_other1.pdf K0005193_fulltext_other2.pdf
Author Sugihara, Yuusaku|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5193号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Acute Vasoreactivity Testing With Nicardipine in Patients With Pulmonary Arterial Hypertension
FullText URL K0005192_abstract_review.pdf K0005192_fulltext.pdf K0005192_fulltext_other.pdf
Author Saito, Yukihiro|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5192号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Does the introduction of newborn hearing screening improve vocabulary development in hearing-impaired children? A population-based study in Japan
FullText URL K0005191_abstract_review.pdf K0005191_fulltext.pdf
Author Ohmori, Shuhei|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5191号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Development of Canine Models of Type 1 Diabetes With Partial Pancreatectomy and the Administration of Streptozotocin
FullText URL K0005190_abstract_review.pdf K0005190_fulltext.pdf
Author Seita, Masayuki|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5190号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Prevalence, Risk Factors, and Short-term Consequences of Traumatic Brain Injury-Associated Hyponatremia
FullText URL K0005189_abstract_review.pdf K0005189_fulltext.pdf
Author Yumoto, Tetsuya|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5189号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Postoperative change in the length and　extrusion of the medial meniscus after anterior cruciate ligament reconstruction
FullText URL K0005188_abstract_review.pdf K0005188_summary.pdf K0005188_fulltext.pdf
Author Narazaki, Shinji|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5188号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
The Efficacy and Safety of Single-Session Endoscopic Ultrasound-Guided　Fine Needle Aspiration and Endoscopic Retrograde Cholangiopancreatography　for Evaluation of Pancreatic Masses
FullText URL K0005187_abstract_review.pdf K0005187_fulltext.pdf
Author Noma, Yasuhiro|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5187号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Local recurrence and complications after percutaneous radiofrequency ablation of hepatocellular carcinoma: analysis focused on tumor location
FullText URL K0005186_abstract_review.pdf K0005186_fulltext.pdf
Author Toshimori, Junichi|
Published Date 2015-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5186号
Granted Date 2015-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
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