| ID | 30448 |
| JaLCDOI | |
| FullText URL | |
| Author |
Haruta, Yuro
Takahashi, Isao
Sekito, Noriko
Miyamoto, Kanji
Shimamoto, Masaaki
Wakita, Yoshiharu
Kikkawa, Kiyoshi
Nakamura, Toru
Seto, Takumi
Yamashita, Jiro
Yorimiysu, Seiichi
Miyake, Susumu
Machida, Ken-ichi
Kimura, Ikuro
|
| Abstract | A rare case of variant Philadelphia (Ph1) chromosome positive [46, XX, t (9; 22) (q34; q11), inv (9) (9q22; 22q13)] chronic myelocytic leukemia (CML) was described. The patient, 73 years old female, was hospitalized to our hospital because of leukocytosis. Hematological findings corresponded to those of CMLs. However, this case lacked hepatosplenomegaly. Southern blot analysis using a 3 breakpoint cluster region (bcr) probe revealed a bcr rearrangement. The patient has been in the chronic phase for sixteen months without treatment. Clinical and chromosomal changes are under observation in order to get accumulate data for a pathophysiological analysis of variant Ph1 positive CMLs. |
| Keywords | variant Ph1 positive chronic myelocytic leukemia
bcr rearrangement
|
| Amo Type | Article
|
| Publication Title |
Acta Medica Okayama
|
| Published Date | 1990-10
|
| Volume | volume44
|
| Issue | issue5
|
| Publisher | Okayama University Medical School
|
| Start Page | 283
|
| End Page | 286
|
| ISSN | 0386-300X
|
| NCID | AA00508441
|
| Content Type |
Journal Article
|
| language |
English
|
| File Version | publisher
|
| Refereed |
True
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| PubMed ID | |
| Web of Science KeyUT |
