| ID | 16876 |
| Eprint ID | 16876
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| FullText URL | |
| Title Alternative | Immunochemotherapy with tumor antibody-Neocarzinostatin (NCS) conjugates. Part Ⅱ. Biological activities of antibody-NCS conjugates (NCS-immune IgG)
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| Author |
Kobayashi, Takashi
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| Abstract | Anti-NALL-1 rabbit IgG was incubated with NCS, an unique membrane-reactive anticancer antibiotic, in the presence of water-soluble carbodiimide. The resulting mixture contained NCS-immune IgG. The conjugates inhibited the growth and (3)H-TdR incorporation of human leukemia cell line (NALL-1) cells. A membrane immunofluorescent test with FITC-labeled rabbit anti-NCS and goat anti-rabbit IgG antibodies showed specific localization of NCS-immune IgG on NALL-1 cell surfaces. These results indicate that NCS-immune IgG retains both NCS and antibody activities, and NCS-immune IgG should be useful for cancer therapy.
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| Keywords | 免疫化学療法
抗腫瘍抗体結合抗癌剤
Neocarzinostatin
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| Published Date | 1982-10-30
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume94
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| Issue | issue9-10
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 783
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| End Page | 790
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/94/9-10/94_9-10_783/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
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