モノクロロベンゼン中毒に関する研究 第2編 モノクロロベンゼン暴露後のマウス臓器内分布

The distribution of monochlorobenzene among the organs of mice was investigated by gas chromatographic equilibration after inhalation of 500ppm of monochlorobenzene for 1 hour, 300ppm for 1 hour, 100ppm for 1 hour and 100ppm for 3 hours.Monochlorobenzene was detected just after exposure at concentrations in the descending order of that in the adipose tissue, liver, kidneys, blood, heart and brain. The biological half-lives in the second phase of monochlorobenzene accumulation in the organs were in the descending order of length in the adipose tissue, brain, liver, spleen, kidneys and blood. There was a correlation between the amounts of lipid in the organs and the biological half-lives in the second phase. Biological half-lives in the second phase of monochlorobenzene accumulation in the blood, brain, liver and kidneys were in the descending order of exposure: 500ppm for 1 hour, 300ppm for 1 hour and 100ppm for 1 hour. Concentrations of monochlorobenzene in the blood, brain, liver and kidneys just after exposure to 300ppm of monochlorobenzene for 1 hour were higher than that after exposure to 100ppm for 3 hours. However, the biological half-life in the second phase after exposure to 100ppm for 3 hours was longer than that after exposure to 300ppm for 1 hour. The biological half-life in the second phase after exposure to 100ppm for 3 hours was longer than that after exposure to 100ppm for 1 hour.