| ID | 56464 |
| JaLCDOI | |
| FullText URL | |
| Author |
Abe, Yoshiyuki
Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
Fujibayashi, Kazutoshi
Medical Technology Innovation Center, Juntendo University
Nishizaki, Yuji
Medical Technology Innovation Center, Juntendo University
Yanagisawa, Naotake
Medical Technology Innovation Center, Juntendo University
Nojiri, Shuko
Clinical Research and Trial Center, Juntendo University Hospital
Nakano, Soichiro
Geriatric General Medicine, Juntendo Tokyo Koto Geriatric Medical Center
Tada, Kurisu
Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
Yamaji, Ken
Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
Tamura, Naoto
Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine
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| Abstract | Pneumocystis pneumonia (PCP) due to Pneumocystis jirovecii infection is the leading cause of fatal opportunistic infections in immunocompromised patients. We will determine whether a daily sulfamethoxazole-trimethoprim (SMX/TMP) dose of 200/40 mg was non-inferior to 400/80 mg for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. This is a randomized, open-label, multicenter controlled trial. The primary outcome is the rate of PCP prevention at 52 weeks. The secondary outcome is the discontinuation rate of SMX/TMP. The trial will evaluate the optimal dose of SMX/TMP for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy.
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| Keywords | pneumocystis pneumonia
prophylaxis
systemic rheumatic disease
sulfamethoxazole-trimethoprim
conventional-dose versus half-dose
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| Amo Type | Clinical Study Protocol
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| Publication Title |
Acta Medica Okayama
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| Published Date | 2019-02
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| Volume | volume73
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| Issue | issue1
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| Publisher | Okayama University Medical School
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| Start Page | 85
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| End Page | 89
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| ISSN | 0386-300X
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| NCID | AA00508441
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| Content Type |
Journal Article
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| language |
English
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| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School
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| File Version | publisher
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| Refereed |
True
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| PubMed ID |
