result 46562 件
| JaLCDOI | 10.18926/AMO/68727 |
|---|---|
| FullText URL | 79_3_197.pdf |
| Author | Kondo, Naoki| Kakutani, Rika| Mochizuki, Tomoharu| Wakui, Junichi | Hao, Nariaki| Kinoshita, Eiji| Kawashima, Hiroyuki| |
| Abstract | A 67-year-old woman with rheumatoid arthritis presented with an untriggered hematoma in the right shoulder joint. Radiographic findings showed humeral head collapse and destruction of the glenoid fossa with ectopic calcification. Calcium pyrophosphate deposition (CPPD) in the synovial fluid was observed using a polarizing microscope. Histopathological findings revealed chronic inflammatory cell infiltration and giant cells surrounded by CPPD. The patient was diagnosed with rapid destructive arthropathy (RDA). Endoscopic shoulder joint debridement was performed. Postoperatively, active flexion improved from 40 to 75 degrees. This case highlights that CPPD can cause RDA in the shoulder, detectable with detailed histopathology. |
| Keywords | rheumatoid arthritis calcium pyrophosphate deposition rapid destructive arthropathy case report |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 197 |
| End Page | 203 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68726 |
|---|---|
| FullText URL | 79_3_185.pdf |
| Author | Yoshikawa, Ayumi| Taira, Naruto| Okanaga, Mayumi| Saito, Shinya| |
| Abstract | We investigated the emotional changes that young patients with breast cancer need to undergo in order to foster relationship-building with their partners by conducting a qualitative descriptive study (March 1 to Nov. 26, 2021) and semi-structured interviews with eight postoperative patients (age 20-40 years) with breast cancer. The data were analyzed using the modified grounded theory approach (M-GTA), yielding five categories: (i) Awareness of being a breast cancer patient, (ii) Being at a loss, (iii) Support from significant others, (iv) The struggle to transition from being a patient with cancer to becoming “the person I want to be”, and (v) Reaching the “me” I want to be who can face building a relationship with a partner. These findings suggest that young breast cancer patients must feel that they can lead a normal life through activities such as work or acquiring qualifications before building relationships with their partners, and that getting closer to their desired selves is important. Nurses can provide information to young patients with breast cancer to assist them in building a solid relationship with their partners. We believe that this support may enhance the patients’ quality of life and help them achieve stronger relationships with their partners. |
| Keywords | breast cancer patient young patient single partners relationships |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 185 |
| End Page | 195 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68725 |
|---|---|
| FullText URL | 79_3_177.pdf |
| Author | Furuichi, Shuro| Mitani, Shigeru| Endo, Hirosuke| Namba, Yoshifumi| Kawamoto, Toyohiro| |
| Abstract | The position attained in total hip arthroplasty (THA) is ideally in the center of the horizontal plane of the acetabulum. However, central placement is not always possible. We hypothesized that differences in approach result in individual differences in cup positioning; thus, we investigated the cup positions of 217 hips that underwent THA. The acetabulum’s anteroposterior diameter was measured, and the cups placed within 2 mm of the line perpendicular to the center as a central placement (central). Of the 217 hips, 68, 114, and 35 hips were anterior, central, and posterior, respectively. In 21 hips, anteroposterior deviation was noted. Among patients operated using the anterolateral approach, 48, 93, and 30 hips were anterior, central, and posterior, respectively. Among those operated using the posterolateral approach, 16, 20, and 4 hips were anterior, central, and posterior, respectively. The cup position shifted either anteriorly or posteriorly to the acetabulum in approximately half of all hips operated using both approaches and tended to shift anteriorly in the hips operated using the posterolateral approach. During THA surgery, it is important to operate with awareness of the center of the acetabulum. |
| Keywords | total hip arthroplasty cup horizontal position total hip arthroplasty approach navigation system computed tomography |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 177 |
| End Page | 184 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68724 |
|---|---|
| FullText URL | 79_3_167.pdf |
| Author | Kanaji, Nobuhiro| Nishii, Kazuya| Tsubata, Yukari| Nakao, Mika| Okuno, Takae| Okawa, Sachi| Takata, Kenji| Kodani, Masahiro| Yamasaki, Masahiro| Fujitaka, Kazunori| Kubota, Tetsuya| Inoue, Masaaki| Watanabe, Naoki| Hotta, Katsuyuki| CS-Lung-003 Investigator| |
| Abstract | This prospective observational study investigated the clinical status of patients with advanced non-small cell lung cancer (NSCLC) treated with cytotoxic chemotherapy+an immune checkpoint inhibitor (chemo + IO) as first-line treatment in a real-world setting. The cases of 98 patients treated with chemo + IO were prospectively collected and analyzed for effectiveness and safety. The response rate to chemo + IO was 46.9%, and the disease control rate was 76.5%. The median progression-free survival and overall survival (OS) in the total population were 5.2 and 22.3 months, respectively. The patients positive for PD-L1 (≥ 1%) showed significantly longer OS than the negative group (<1%) (median 26.7 vs. 18.7 months, p=0.04). Pre-existing interstitial lung disease (ILD) was associated with shorter OS than the absence of ILD (median 9.0 vs. 22.6 months, p<0.01). Immunerelated adverse events (irAEs) were observed in 28 patients (28.6%). The most frequent irAE was ILD (n=11); Grade 1 (n=1 patient), G2 (n=5), G3 (n=4), and only a single patient with a G5 irAE. In this CS-Lung-003 study, first-line chemo + IO in a real-world setting showed good effectiveness, comparable to that observed in international clinical trials. In real-world practice, chemo + IO is a promising and steadfast strategy. |
| Keywords | non-small cell lung cancer real-world first-line immune checkpoint inhibitor combined immunotherapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 167 |
| End Page | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68723 |
|---|---|
| FullText URL | 79_3_157.pdf |
| Author | Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Takahashi, Hideo| Wake, Hidenori| |
| Abstract | Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3. |
| Keywords | advanced glycation end product aging cartilage collagen aggrecan |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 157 |
| End Page | 166 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68722 |
|---|---|
| FullText URL | 79_3_147.pdf |
| Author | Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun| |
| Abstract | Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes. |
| Keywords | systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 147 |
| End Page | 155 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Bufetov, Alexander I.| Kawamoto, Yosuke| |
| Keywords | Random matrices Intertwining relation Interacting Brownian motions |
| Note | The version of record of this article, first published in Journal of Statistical Physics, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10955-025-03441-w| |
| Published Date | 2025-04-16 |
| Publication Title | Journal of Statistical Physics |
| Volume | volume192 |
| Issue | issue5 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 58 |
| ISSN | 1572-9613 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| DOI | 10.1007/s10955-025-03441-w |
| Web of Science KeyUT | 001469294100001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10955-025-03441-w |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kondo, Maiko| Kurita, Yoshihiko| Fukushima, Yosuke| Shigemitsu, Yusuke| Hirai, Kenta| Kawamoto, Yuya| Hara, Mayuko| Kanazawa, Tomoyuki| Iwasaki, Tatsuo| Kotani, Yasuhiro| Kasahara, Shingo| Tsukahara, Hirokazu| Baba, Kenji| |
| Keywords | Ultra-high-pressure balloon Balloon angioplasty Congenital heart disease |
| Note | The version of record of this article, first published in Heart and Vessels, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00380-025-02547-1| |
| Published Date | 2025-05-06 |
| Publication Title | Heart and Vessels |
| Publisher | Springer Science and Business Media LLC |
| ISSN | 0910-8327 |
| NCID | AA10452161 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 40328970 |
| DOI | 10.1007/s00380-025-02547-1 |
| Web of Science KeyUT | 001482109000001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00380-025-02547-1 |
| Author | Tokushige, Keisuke| Abe, Takumi| |
|---|---|
| Keywords | Deaminokynurenines Enolates Indoline hemiaminals Potassium tertbutoxide Tautomerism |
| Note | This is the peer reviewed version of the following article: [K. Tokushige, T. Abe*, Asian Journal of Organic Chemistry. 2025, 00. https://doi.org/10.1002/ajoc.202500439], which has been published in final form at [https://doi.org/10.1002/ajoc.202500439]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in May. 2026.| |
| Published Date | 2025-05-01 |
| Publication Title | Asian Journal of Organic Chemistry |
| Publisher | Wiley |
| Start Page | e202500439 |
| ISSN | 2193-5807 |
| NCID | AA12586329 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Wiley-VCH GmbH |
| File Version | author |
| DOI | 10.1002/ajoc.202500439 |
| Web of Science KeyUT | 001479453400001 |
| Related Url | isVersionOf https://doi.org/10.1002/ajoc.202500439 |
| Author | Takeda, Tatsuaki| Matsumoto, Jun| Sakai, Tomonori| Iwata, Naohiro| Hamano, Hirofumi| Koyama, Toshihiro| Ariyoshi, Noritaka| Zamami, Yoshito| |
|---|---|
| Keywords | adverse event breast cancer pertuzumab trastuzumab VigiBase |
| Note | This is the peer reviewed version of the following article: [Takeda T, Matsumoto J, Sakai T, et al. Comprehensive analysis of adverse event profile changes with pertuzumab addition to trastuzumab-based breast cancer therapy: Disproportionality analysis using VigiBase. Br J Clin Pharmacol. 2025; 1-13. doi:10.1002/bcp.70094], which has been published in final form at [https://doi.org/10.1002/bcp.70094]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in May. 2026.| |
| Published Date | 2025-05-08 |
| Publication Title | British Journal of Clinical Pharmacology |
| Publisher | Wiley |
| ISSN | 0306-5251 |
| NCID | AA00574388 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 British Pharmacological Society. |
| File Version | author |
| PubMed ID | 40344285 |
| DOI | 10.1002/bcp.70094 |
| Web of Science KeyUT | 001483932800001 |
| Related Url | isVersionOf https://doi.org/10.1002/bcp.70094 |
| Author | JINZENJI, Masao| MATSUZAKA, Kohki| |
|---|---|
| Keywords | generalized hypergeometric functions Givental's I-function moduli space of quasimaps |
| Note | This fulltext file will be available in Apr. 2028.| |
| Published Date | 2025-04 |
| Publication Title | Journal of the Mathematical Society of Japan |
| Volume | volume77 |
| Issue | issue2 |
| Publisher | Mathematical Society of Japan (Project Euclid) |
| Start Page | 449 |
| End Page | 482 |
| ISSN | 0025-5645 |
| NCID | AA0070177X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Mathematical Society of Japan |
| File Version | publisher |
| DOI | 10.2969/jmsj/90489048 |
| Web of Science KeyUT | 001473865200001 |
| Related Url | isVersionOf https://doi.org/10.2969/jmsj/90489048 |
| FullText URL | jhg_3_contents_e.pdf |
|---|---|
| Publication Title | Journal of humanistic gerontology |
| Published Date | 2024-03-31 |
| Volume | volume3 |
| ISSN | 2435-5747 |
| language | Japanese |
| File Version | publisher |
| FullText URL | jhg_3_colophon.pdf |
|---|---|
| Publication Title | Journal of humanistic gerontology |
| Published Date | 2024-03-31 |
| Volume | volume3 |
| ISSN | 2435-5747 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/JHG/68714 |
|---|---|
| Title Alternative | Forming a mindset of A consideration on being a burden : Relationship with education |
| FullText URL | jhg_3_22_54.pdf |
| Author | DENG, Xiaofan| |
| Publication Title | Journal of humanistic gerontology |
| Published Date | 2024-03-31 |
| Volume | volume3 |
| Start Page | 22 |
| End Page | 54 |
| ISSN | 2435-5747 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/JHG/68713 |
|---|---|
| Title Alternative | Memoirs of NISHIDA Kitaro's Death |
| FullText URL | jhg_3_1_21.pdf |
| Author | SUZUKI, Ryozo| YAMAMOTO, Koichiro| OBIKA, Mikako| |
| Publication Title | Journal of humanistic gerontology |
| Published Date | 2024-03-31 |
| Volume | volume3 |
| Start Page | 1 |
| End Page | 21 |
| ISSN | 2435-5747 |
| language | Japanese |
| File Version | publisher |
| FullText URL | jhg_3_contents.pdf |
|---|---|
| Publication Title | Journal of humanistic gerontology |
| Published Date | 2024-03-31 |
| Volume | volume3 |
| ISSN | 2435-5747 |
| language | Japanese |
| File Version | publisher |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fukushima, Kazuhiko| Tsuji, Kenji| Nakanoh, Hiroyuki| Uchida, Naruhiko| Haraguchi, Soichiro| Kitamura, Shinji| Wada, Jun| |
| Keywords | artificial intelligence case reports peritoneal dialysis text mining |
| Published Date | 2025-03-26 |
| Publication Title | Therapeutic Apheresis and Dialysis |
| Volume | volume29 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 459 |
| End Page | 470 |
| ISSN | 1744-9979 |
| NCID | AA12013945 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 40143459 |
| DOI | 10.1111/1744-9987.70013 |
| Web of Science KeyUT | 001480833800002 |
| Related Url | isVersionOf https://doi.org/10.1111/1744-9987.70013 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakanoh, Hiroyuki| Tsuji, Kenji| Fukushima, Kazuhiko| Haraguchi, Soichiro| Kitamura, Shinji| Wada, Jun| |
| Keywords | Acute kidney injury Drug-induced nephrotoxicity Kidney organoid Kidney stem cell |
| Published Date | 2025-02-20 |
| Publication Title | American Journal of Nephrology |
| Publisher | S. Karger AG |
| ISSN | 0250-8095 |
| NCID | AA10424676 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 39978331 |
| DOI | 10.1159/000544795 |
| Web of Science KeyUT | 001468823100001 |
| Related Url | isVersionOf https://doi.org/10.1159/000544795 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kuriu, Ayano| Ishikawa, Kazuya| Tsuchiya, Kohsuke| Furuta, Kazuyuki| Kaito, Chikara| |
| Keywords | animal infection model Staphylococcus aureus Listeria monocytogenes Pseudomonas aeruginosa antibiotics efficacy virulence genes hemolysin |
| Published Date | 2025-05-01 |
| Publication Title | Infection and Immunity |
| Publisher | American Society for Microbiology |
| ISSN | 0019-9567 |
| NCID | AA00673732 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Kuriu et al. |
| File Version | publisher |
| PubMed ID | 40310291 |
| DOI | 10.1128/iai.00126-25 |
| Web of Science KeyUT | 001479415700001 |
| Related Url | isVersionOf https://doi.org/10.1128/iai.00126-25 |
| Author | Kawajiri, Takahiro| Hosoya, Masahiro| Goda, Satoshi| Sato, Eisuke| Suga, Seiji| |
|---|---|
| Note | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.5c01138.| This fulltext file will be available in Apr. 2026.| |
| Published Date | 2025-04-29 |
| Publication Title | Organic Letters |
| Volume | volume27 |
| Issue | issue18 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 4737 |
| End Page | 4741 |
| ISSN | 1523-7060 |
| NCID | AA11347843 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 American Chemical Society |
| File Version | author |
| PubMed ID | 40302371 |
| DOI | 10.1021/acs.orglett.5c01138 |
| Web of Science KeyUT | 001479279200001 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.orglett.5c01138 |
