Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer

Tanakaya, Kohji; Yamaguchi, Tatsuro; Hirata, Keiji; Yamada, Masayoshi; Kumamoto, Kensuke; Akiyama, Yasuki; Ishimaru, Kei; Okamoto, Koichi; Kawasaki, Yuko; Komine, Keigo; Sakamoto, Akira; Shigeyasu, Kunitoshi; Shibata, Yoshiko; Shimamoto, Yusaku; Shimodaira, Hideki; Sekine, Shigeki; Takao, Akinari; Takao, Misato; Takamizawa, Yasuyuki; Takeuchi, Yoji; Tanabe, Noriko; Taniguchi, Fumitaka; Chino, Akiko; Cho, Hourin; Doi, Satoru; Nakajima, Takeshi; Nakamori, Sakiko; Nakayama, Yoshiko; Nagasaki, Toshiya; Hasumi, Hisashi; Banno, Kouji; Hinoi, Takao; Fujiyoshi, Kenji; Horimatsu, Takahiro; Masuda, Kenta; Miguchi, Masashi; Mizuuchi, Yusuke; Miyakura, Yasuyuki; Mutoh, Michihiro; Yoshioka, Takahiro; Tanaka, Shinji; Sakamoto, Kazuhiro; Sakamaki, Kentaro; Itabashi, Michio; Ishida, Hideyuki; Tomita, Naohiro; Sugihara, Kenichi; Ajioka, Yoichi

doi:10.1007/s10147-025-02892-1

Permalink : https://ousar.lib.okayama-u.ac.jp/69575

ID	69575
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Author	Tanakaya, Kohji Department of Surgery, National Hospital Organization Iwakuni Clinical Center Yamaguchi, Tatsuro Department of Clinical Genetics, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Hirata, Keiji Department of Surgery 1, University of Occupational and Environmental Health Yamada, Masayoshi Endoscopy Division, National Cancer Center Hospital Kumamoto, Kensuke Department of Genome Medical Science and Medical Genetics, Faculty of Medicine, Kagawa University Akiyama, Yasuki Department of Surgery 1, University of Occupational and Environmental Health Ishimaru, Kei Division of Gastrointestinal Surgery and Surgical Oncology, Graduate School of Medicine, Ehime University Okamoto, Koichi Department of Gastroenterology and Oncology, Tokushima University Graduate School of Medical Science Kawasaki, Yuko College of Nursing, University of Hyogo Komine, Keigo Department of Medical Oncology, Tohoku University Hospital Sakamoto, Akira Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Shigeyasu, Kunitoshi Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Shibata, Yoshiko Himawari-No-Kai (Sunflower Association), a Patient Advocacy Group for Individuals and Families Affected By Lynch Syndrome Shimamoto, Yusaku Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine Shimodaira, Hideki Division of Medical Oncology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University Sekine, Shigeki Department of Pathology, Keio University School of Medicine Takao, Akinari Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Takao, Misato Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Takamizawa, Yasuyuki Department of Colorectal Surgery, National Cancer Center Hospital Takeuchi, Yoji Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine Tanabe, Noriko Department of Clinical Genetics, Saitama Medical Center, Saitama Medical University Taniguchi, Fumitaka Department of Surgery, Hiroshima City Hospital Organization Hiroshima City Hiroshima Citizens Hospital Chino, Akiko Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research Cho, Hourin Endoscopy Center, Tokyo Medical University Hospital Doi, Satoru Harmony Line (Association for Patients and Families With Familial Adenomatous Polyposis) Nakajima, Takeshi Division of Hereditary Tumors, Department of Genetic Oncology, Osaka International Cancer Institute Nakamori, Sakiko Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Nakayama, Yoshiko Department of Pediatrics, Shinshu University School of Medicine Nagasaki, Toshiya Department of Gastroenterological Surgery, Saitama Cancer Center Hasumi, Hisashi Department of Urology, Yokohama City University Banno, Kouji Center of Maternal -Fetal/Neonatal Medicine, Hiroshima University Hospital Hinoi, Takao Department of Clinical and Molecular Genetics, Hiroshima University Hospital Fujiyoshi, Kenji Department of Surgery, Kurume University School of Medicine Horimatsu, Takahiro Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital Masuda, Kenta Department of Obstetrics and Gynecology, Keio University School of Medicine Miguchi, Masashi Department of Gastroenterological Surgery, Hiroshima Prefectural Hospital Mizuuchi, Yusuke Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University Miyakura, Yasuyuki Department of Colon and Pelvic Surgery, Cancer Prevention and Genetic Counseling, Tochigi Cancer Center Mutoh, Michihiro Department of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine Yoshioka, Takahiro Department of Gastroenterological Surgery, Kochi Health Sciences Center Tanaka, Shinji JA Onomichi General Hospital Sakamoto, Kazuhiro Koshigaya Municipal Hospital Sakamaki, Kentaro Faculty of Health Data Science, Juntendo University Itabashi, Michio Saiseikai Kazo Hospital Ishida, Hideyuki Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University Tomita, Naohiro Division of Cancer Treatment , Toyonaka Municipal Hospital Sugihara, Kenichi Institute of Science Tokyo Ajioka, Yoichi Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University
Abstract	Approximately 5% of all colorectal cancers have a strong genetic component and are classified as hereditary colorectal cancer (HCRC). Some of the unique features commonly seen in HCRC cases include early age of onset, synchronous/metachronous cancer occurrence, and multiple cancers in other organs. These characteristics require different management approaches, including diagnosis, treatment or surveillance, from those used in the management of sporadic colorectal cancer. Accurate diagnosis of HCRC is essential because it enables targeted surveillance and risk reduction strategies that improve patient outcomes. Recent genetic advances revealed several causative genes for polyposis and non-polyposis syndromes. The Japanese Society for Cancer of the Colon and Rectum (JSCCR) first published guidelines for the management of HCRC in 2012, with subsequent revisions every 4 years. The 2024 update to the JSCCR guidelines for HCRC was developed by meticulously reviewing evidence from systematic reviews and the consensus of the JSCCR HCRC Guidelines Committee, which includes representatives from patient advocacy groups for FAP and Lynch syndrome. These guidelines provide an up-to-date summary of HCRC, along with clinical recommendations for managing FAP and Lynch syndrome.
Keywords	Hereditary colorectal cancer Guidelines Familial adenomatous polyposis Lynch syndrome
Published Date	2025-11-10
Publication Title	International Journal of Clinical Oncology
Publisher	Springer Science and Business Media LLC
ISSN	1341-9625
NCID	AA11086579
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	41214301
DOI	10.1007/s10147-025-02892-1
Web of Science KeyUT	001610539800001
Related Url	isVersionOf https://doi.org/10.1007/s10147-025-02892-1
License	http://creativecommons.org/licenses/by/4.0/
Citation	Tanakaya, K., Yamaguchi, T., Hirata, K. et al. Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer. Int J Clin Oncol (2025). https://doi.org/10.1007/s10147-025-02892-1
助成情報	( JSCCR )