| ID | 16168 |
| Eprint ID | 16168
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| FullText URL | |
| Title Alternative | Integration of HBV DNA in hepatocellular carcinoma
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| Author |
Hada, Hajime
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| Abstract | In order to clarify the relationship between hepatocellular carcinoma (HCC) and integration of hepatitis B virus (HBV) DNA into the host hepatocyte genome, the states of HBV DNA in 14 cases of HCC, 3 cases of chronic hepatitis, 2 cases of metastatic hepatic carcinoma and 4 normal livers were examined by the Southern blot hybridization technique. All 3 cases of HCC positive for serum HBsAg had both free and integrated HBV DNA. Integration of HBV DNA without free HBV DNA was detected in 2 cut of 4 HCC cases negative for serum HBsAg but positive for more than one of the HBV-related antibodies. Only free HBV DNA was observed in all 3 cases of chronic hepatitis positive for serum HBsAg. The remaining cases had no HBV DNA in their liver tissues.
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| Keywords | HBVDNA
hepatocellular carcinoma
Southern transfer
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| Published Date | 1985-06-30
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume97
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| Issue | issue5-6
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 465
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| End Page | 473
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/97/5-6/97_5-6_465/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
|
