| ID | 56117 |
| FullText URL | |
| Author |
Ono, Kisho
Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Eguchi , Takanori
Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Sogawa, Chiharu
Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Calderwood, Stuart K.
Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
Futagawa, Junya
Department of Biomedical Solution Center, Mitsui Knowledge Industry
Kasai, Tomonari
Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University
Seno, Masaharu
Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University
Okamoto, Kuniaki
Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Sasaki, Akira
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Kozaki, Ken‐ichi
Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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| Abstract | Cancer cells often secrete extracellular vesicles (EVs) that carry heat shock proteins (HSPs) with roles in tumor progression. Oral squamous cell carcinoma (OSCC) belongs to head and neck cancers (HNC) whose lymph-node-metastases often lead to poor prognosis. We have examined the EV proteome of OSCC cells and found abundant secretion of HSP90-enriched EVs in lymph-node-metastatic OSCC cells. Double knockdown of HSP90α and HSP90β, using small interfering RNA significantly reduced the survival of the metastatic OSCC cells, although single knockdown of each HSP90 was ineffective. Elevated expression of these HSP90 family members was found to correlate with poor prognosis of HNC cases. Thus, elevated HSP90 levels in secreted vesicles are potential prognostic biomarkers and therapeutic targets in metastatic OSCC.
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| Keywords | EV proteomics
exosome
extracellular vesicle
heat shock proteins
lymph-node-metastatic oral cancer
molecular chaperone
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| Published Date | 2018-05-16
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| Publication Title |
Journal of Cellular Biochemistry
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| Volume | volume119
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| Issue | issue9
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| Publisher | Wiley
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| Start Page | 7350
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| End Page | 7362
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| ISSN | 07302312
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| NCID | AA1052210X
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| File Version | author
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| Related Url | isVersionOf https://doi.org/10.1002/jcb.27039
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