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JaLCDOI 10.18926/AMO/60371
FullText URL 74_4_327.pdf
Author Yamamoto, Ken-ichi| Kagawa, Hiroko| Arimoto, Sakae| Tan, Xian Wen| Yasui, Kento| Oshiki, Toshiyuki| Sakaguchi, Masakiyo|
Abstract An increasing accumulation of microplastics and further degraded nanoplastics in our environment is suspected to have harmful effects on humans and animals. To clarify this problem, we tested the cytotoxicity of two types of plastic wrap on human cultured liver cells and mouse primary cultured liver cells. Alcohol extracts from plastic wrap, i.e., polyvinylidene chloride (PVDC), showed cytotoxic effects on the cells. Alcohol extracts of polyethylene (PE) wrap were not toxic. The commercially available PVDC wrap consists of vinylidene chloride, epoxidized soybean oil, epoxidized linseed oil as a stiffener and stabilizer; we sought to identify which component(s) are toxic. The epoxidized soybean oil and epoxidized linseed oil exerted strong cytotoxicity, but the plastic raw material itself, vinylidene chloride, did not. Our findings indicate that plastic wraps should be used with caution in order to prevent health risks.
Keywords plastic wrap plasticizer, cytotoxicity, liver cells in vitro
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 327
End Page 334
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843764
Web of Science KeyUT 000562508700008
NAID 120006880210
JaLCDOI 10.18926/AMO/60370
FullText URL 74_4_319.pdf
Author Isoyama, Satoshi| Kimura, Satoshi| Morimatsu, Hiroshi|
Abstract Little is known about the role of a strong ions in humans with respiratory abnormalities. In this study, we investigated the associations between partial carbon dioxide pressure (pCO2) and each of sodium ion (Na+) concentrations, chloride ion (Cl−) concentrations and their difference (SIDNa-Cl). Blood gas data were obtained from patients in a teaching hospital intensive care unit between August 2013 and January 2017. The association between pCO2 and SIDNa-Cl was defined as the primary outcome. The associations between pCO2 and [Cl−], [Na+] and other strong ions were secondary outcomes. pCO2 was stratified into 10 mmHg-wide bands and treated as a categorical variable for comparison. As a result, we reviewed 115,936 blood gas data points from 3,840 different ICU stays. There were significant differences in SIDNa-Cl, [Cl−], and [Na+] among all categorized pCO2 bands. The respective pCO2 SIDNa-Cl, [Cl−], and [Na+] correlation coefficients were 0.48, −0.31, and 0.08. SIDNa-Cl increased and [Cl−] decreased with pCO2, with little relationship between pCO2 and [Na+] across subsets. In conclusion, we found relatively strong correlations between pCO2 and SIDNa-Cl in the multiple blood gas datasets examined. Correlations between pCO2 and chloride concentrations, but not sodium concentrations, were further found to be moderate in these ICU data.
Keywords acid-base phenomena Stewart approach strong ion difference chlorine ion partial carbon dioxide pressure
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 319
End Page 325
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843763
Web of Science KeyUT 000562508700007
NAID 120006880209
JaLCDOI 10.18926/AMO/60369
FullText URL 74_4_307.pdf
Author Nagamine, Yuichi| Hasibul, Khaleque| Ogawa, Takaaki| Tada, Ayano| Kamitori, Kazuyo| Hossain, Akram| Yamaguchi, Fuminori| Tokuda, Masaaki| Kuwahara, Tomomi| Miyake, Minoru|
Abstract We examined the effect of D-Tagatose on the growth of oral bacteria including Streptococcus mutans (S. mutans). Saliva collected from 10 healthy volunteers was plated on BHI medium (to culture total oral bacteria) and MBS medium (to culture S. mutans, specifically). Agar plates of BHI or MBS containing xylitol or D-Tagatose were cultured under aerobic or anaerobic conditions. We then counted the number of colonies. In BHI plates containing D-Tagatose, a complete and significant reduction of bacteria occurred under both aerobic and anaerobic conditions. In MSB medium, significant reduction of S. mutans was also observed. We then performed a doubleblind parallel randomized trial with 19 healthy volunteers. They chewed gum containing xylitol, D-Tagatose, or both for 4 weeks, and their saliva was collected weekly and plated on BHI and MSB media. These plates were cultured under anaerobic conditions. Total bacteria and S. mutans were not effectively reduced in either the D-Tagatose or xylitol gum group. However, S. mutans was significantly reduced in volunteers chewing gum containing both D-Tagatose and xylitol. Thus, D-Tagatose inhibited the growth of S. mutans and many types of oral bacteria, indicating that D-Tagatose intake may help prevent dental caries, periodontitis, and many oral diseases.
Keywords D-Tagatose xylitol Streptococcus mutans oral bacteria chewing gum
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 307
End Page 317
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843762
Web of Science KeyUT 000562508700006
NAID 120006880208
JaLCDOI 10.18926/AMO/60368
FullText URL 74_4_301.pdf
Author Takahashi, Kei| Kitamura, Yoshihisa| Ushio, Soichiro| Sendo, Toshiaki|
Abstract Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear. We examined the effects of ketamine on the immobility times of adrenocorticotropic hormone (ACTH)-treated rats during the forced swim test, and we explored the mechanism by which ketamine acts in this model. We investigated the neuroanatomical site of action by microinjecting ketamine into the medial prefrontal cortex of rats. A significant reduction of the rats’ immobility during the forced swim test was observed after the intraperitoneal injection of ketamine in both saline- and ACTH-treated rats. The microinjection of ketamine into the medial prefrontal cortex also decreased immobility during the forced swim test in both saline- and ACTH-treated rats. The immobility-decreasing effect of intraperitoneally injected ketamine was blocked by administering WAY100635, a 5-HT1A receptor antagonist, into the medial prefrontal cortex. These findings contribute to the evidence that ketamine can be useful against treatment-resistant depressive conditions. The immobility-reducing effects of ketamine might be mediated by 5-HT1A receptor activity in the medial prefrontal cortex.
Keywords ketamine adrenocorticotropic hormone forced swim test medial prefrontal cortex 5-HT1A receptor
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 301
End Page 306
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843761
Web of Science KeyUT 000562508700005
NAID 120006880207
JaLCDOI 10.18926/AMO/60367
FullText URL 74_4_293.pdf
Author Yoshioka, Takashi| Omae, Kenji| Kawada, Tatsushi| Inoue, Yosuke| Sugimoto, Morito| Oeda, Tadashi| Uehara, Shinya| Araki, Motoo| Fukuhara, Shunichi|
Abstract In this retrospective single-center cohort study, we investigated the impact of preoperative use of an alpha-1 adrenergic receptor (AR) blocker on the outcome of single-session extracorporeal shock wave lithotripsy (SWL) in 193 male patients who underwent SWL for a single ureteral calculus between 2006 and 2016. We reviewed their medical records to obtain the data on the preoperative use of alpha-1 AR blockers. The primary outcome was treatment success after single-session SWL. We performed a multivariable logistic regression analysis adjusting for clinically important confounders to examine the association between preoperative use of alpha-1 AR blockers and the treatment success of SWL. Among the 193 patients, 15 (7.8%) were taking an alpha-1 AR blocker preoperatively. A multivariable analysis showed that preoperative use of an alpha-1 AR blocker was a significant negative predictor for treatment success of SWL (adjusted odds ratio 0.17; 95% confidence intervals, 0.04-0.74). Our findings suggest that the preoperative use of an alpha-1 AR blocker was a negative predictor of treatment success of SWL in male patients with a single ureteral calculus. Clinicians should pay more attention to the preoperative drug use in determining an appropriate stone therapy modality.
Keywords urolithiasis extracorporeal shockwave therapy adrenergic alpha-1 receptor antagonists
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 293
End Page 299
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843760
Web of Science KeyUT 000562508700004
NAID 120006880206
FullText URL fulltext.pdf
Author Kitamura, Shinji| Takahashi, Kensaku| Sang, Yizhen| Fukushima, Kazuhiko| Tsuji, Kenji| Wada, Jun|
Keywords immunofluorescent image renal pathology artificial intelligence deep learning diabetic nephropathy
Published Date 2020-07-09
Publication Title Diagnostics
Volume volume10
Issue issue7
Publisher MDPI
Start Page 466
ISSN 2075-4418
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32660112
DOI 10.3390/diagnostics10070466
Web of Science KeyUT 000557155500001
Related Url isVersionOf https://doi.org/10.3390/diagnostics10070466
JaLCDOI 10.18926/AMO/60365
FullText URL 74_4_285.pdf
Author Tsukahara, Kohei| Naitou, Hiromichi| Yorifuji, Takashi| Nosaka, Nobuyuki| Yamamoto, Hirotsugu| Osako, Takaaki| Nakao, Atsunori| the JaRPAC Study Group|
Abstract The importance of centralizing treatment services for severely ill children has been well established, but such entralization remains difficult in Japan. We aimed to compare the trauma and illness severity and mortality of children admitted to two common types of ICUs for children. According to the type of management and disposition of the medical provider, we classified ICUs as pediatric ICUs [PICUs] or general ICUs, and analyzed differences in endogenous and exogenous illness settings between them. Overall, 1,333 pediatric patients were included, with 1,143 patients admitted to PICUs and 190 patients to general ICUs. The Pediatric Cerebral Performance Category score (PCPC) at discharge was significantly lower in the PICU group (adjusted OR: 0.45; 95%CI: 0.23-0.88). Death and unfavorable neurological outcomes occurred less often in the PICU group (adjusted OR: 0.29; 95%CI: 0.14-0.60). However, when limited to exogenous illness, PCPC scores (adjusted OR: 0.38; 95%CI: 0.07-1.99) or death/unfavorable outcomes (adjusted OR: 0.72; 95%CI: 0.08-6.34) did not differ between the groups. PCPC deterioration and overall sequelae/death rates were lower in PICUs for children with endogenous illnesses, although the outcomes of exogenous illness were similar between the 2 unit types. Further studies on the necessity of centralization are warranted.
Keywords kids critical care mortality morbidity centralization
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 285
End Page 291
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843759
Web of Science KeyUT 000562508700003
NAID 120006880204
JaLCDOI 10.18926/AMO/60364
FullText URL 74_4_275.pdf
Author Muro, Taiko| Nakamura, Shinichiro| Takaki, Akinobu| Onishi, Hideki| Wada, Nozomu| Yasunaka, Tetsuya| Uchida, Daisuke| Oyama, Atsushi| Adachi, Takuya| Shiraha, Hidenori| Okada, Hiroyuki|
Abstract Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment.
Keywords oxidative stress hepatocellular carcinoma recurrence, radiofrequency ablation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 275
End Page 283
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843758
Web of Science KeyUT 000562508700002
NAID 120006880203
JaLCDOI 10.18926/AMO/60363
FullText URL 74_4_265.pdf
Author Inokuchi, Toshihiro| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahar, Masahiro| Kawano, Seiji| Harada, Keita| Okada, Hiroyuki| Kato, Jun|
Abstract Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy.
Keywords Crohn’s disease anti-TNF agent upper gastrointestinal lesion bamboo joint-like appearance
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 265
End Page 274
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843757
Web of Science KeyUT 000562508700001
NAID 120006880202
FullText URL fulltext.pdf
Author Yamashiro, Keisuke| Ideguchi, Hidetaka| Aoyagi, Hiroaki| Yoshihara-Hirata, Chiaki| Hirai, Anna| Suzuki-Kyoshima, Risa| Zhang, Yao| Wake, Hidenori| Nishibori, Masahiro| Yamamoto, Tadashi| Takashiba, Shogo|
Keywords high mobility group box 1 inflammation periodontal regeneration periodontitis osseointegration tooth movement wound healing
Published Date 2020-07-14
Publication Title Frontiers in Immunology
Volume volume11
Publisher Frontiers Media
Start Page 1461
ISSN 1664-3224
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Yamashiro et al.
File Version publisher
PubMed ID 32760399
DOI 10.3389/fimmu.2020.01461
Web of Science KeyUT 000556581900001
Related Url isVersionOf https://doi.org/10.3389/fimmu.2020.01461
FullText URL fulltext.pdf
Author Morikawa, Yuko| Morimoto, Setsuyo| Yoshida, Eri| Naka, Shuhei| Inaba, Hiroaki| Matsumoto-Nakano, Michiyo|
Keywords Streptococcus mutans glutamine transporter biofilm membrane protein glnP
Published Date 2020-08-04
Publication Title Journal of Oral Microbiology
Volume volume12
Issue issue1
Publisher Taylor & Francis
Start Page 1797320
ISSN 2000-2297
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
DOI 10.1080/20002297.2020.1797320
Web of Science KeyUT 000555592200001
Related Url isVersionOf https://doi.org/10.1080/20002297.2020.1797320
FullText URL fulltext.pdf
Author Nanki, Yoshiko| Chiyoda, Tatsuyuki| Hirasawa, Akira| Ookubo, Aki| Itoh, Manabu| Ueno, Masaru| Akahane, Tomoko| Kameyama, Kaori| Yamagami, Wataru| Kataoka, Fumio| Aoki, Daisuke|
Published Date 2020-07-28
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature
Start Page 12581
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 32724113
DOI 10.1038/s41598-020-69488-9
Web of Science KeyUT 000556398500004
Related Url isVersionOf https://doi.org/10.1038/s41598-020-69488-9
FullText URL 48_320.pdf
Author Yumoto, Yasuhiro| Hanafusa, Tadashi| Nagamatsu, Tomohiro| Okada, Shigeru|
Keywords low level radioactive sample (LLRS) low energy β-emitter Imaging Plate experimental incineration system
Published Date 1999-05-15
Publication Title Radioisotopes
Volume volume48
Issue issue5
Publisher 日本アイソトープ協会
Start Page 320
End Page 326
ISSN 00338303
NCID AN00351589
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
NAID 10002684844
FullText URL 46_443.pdf
Author 湯本 泰弘| 花房 直志| 永松 知洋| 岡田 茂|
Keywords low level radioactive sample (LLRS) experimental incineration system for LLRS
Published Date 1997-7-15
Publication Title Radioisotopes
Volume volume46
Issue issue7
Publisher 日本アイソト-プ協会
Start Page 443
End Page 449
ISSN 00338303
NCID AN00351589
Content Type Journal Article
language Japanese
OAI-PMH Set 岡山大学
NAID 10003721742
JaLCDOI 10.18926/okadaironkou/60356
FullText URL okadaironkou_20_81_85.df.pdf
Author 上村 敦之|
Abstract 研究ノート
Publication Title 岡大国文論稿
Published Date 1992-03-31
Issue issue20
Start Page 81
End Page 85
ISSN 0386-3123
language Japanese
File Version publisher
JaLCDOI 10.18926/okadaironkou/60355
FullText URL okadaironkou_20_80_73.pdf
Author 下河部 行輝|
Publication Title 岡大国文論稿
Published Date 1992-03-31
Issue issue20
Start Page 80
End Page 73
ISSN 0386-3123
language Japanese
File Version publisher
JaLCDOI 10.18926/okadaironkou/60354
FullText URL okadaironkou_20_60_71.pdf
Author 石上 敏|
Publication Title 岡大国文論稿
Published Date 1992-03-31
Issue issue20
Start Page 60
End Page 71
ISSN 0386-3123
language Japanese
File Version publisher
JaLCDOI 10.18926/okadaironkou/60353
FullText URL okadaironkou_20_48_59.pdf
Author 高瀬 和子|
Publication Title 岡大国文論稿
Published Date 1992-03-31
Issue issue20
Start Page 48
End Page 59
ISSN 0386-3123
language Japanese
File Version publisher
JaLCDOI 10.18926/okadaironkou/60352
FullText URL okadaironkou_20_38_47.pdf
Author 吉田 俊彦|
Publication Title 岡大国文論稿
Published Date 1992-03-31
Issue issue20
Start Page 38
End Page 47
ISSN 0386-3123
language Japanese
File Version publisher
JaLCDOI 10.18926/okadaironkou/60351
FullText URL okadaironkou_20_26_37.pdf
Author 赤羽 学|
Publication Title 岡大国文論稿
Published Date 1992-03-31
Issue issue20
Start Page 26
End Page 37
ISSN 0386-3123
language Japanese
File Version publisher