癌の増殖に関する研究 第2編 Ehrlich腫瘍及びSarcoma 180の増殖に及ぼす無菌性炎症及び間質成分の影響

The author's previous paper reported that chondroitin sulfate and some other substances accelerated the growth of Ehrlich ascites tumor. In this paper. the author studied the relationship between inflammation and tumor growth. The tumor cells were transplanted to the back of mice where inflammation had been proboked by injecting croton oil two days prior to the transplantation. Experiment 1. The daily growth of the transplanted Ehrlich ascites tumor was observed in the controls and the groups with either chondroitin sulfate or the inflammation until the 14th day after the transplantation when they were killed. The tumor growth in both the chondroitin sulfate group and the inflammation groups was significantly faster than in the control group (P<0.01). Experiment 2. Using sarcoma 180, the same experiment was performed and the same results were obtained as in the Ehrlich ascites tumor. Experiment 3. The influence of chondroitin sulfate and the inflammation on the growth of Ehrlich ascites tumor was histologically studied. 1. Although no morphological differences of the tumor cells themselves were found in the group pretreated with chondroitin sulfate as compared with the control, the space between each tumor cell was wide, and tumor tissue seemed to have grown multifocally. The number of ma-The number of mast cells around the tumor tissue was definitely increased in the chondroitin sulfate group, but there was not so much difference in the amount of connective tissue and metachromatically stained fibers. 2. Compared with the control group, the inflammation group showed large amount of connective tissue around the tumor, and the tumor cells seemed to have been scattered into the network of fibrous tissue. The number of mast cells was decreased in the inflammation group. These findings were not observed in the chondroitin sulfate group.