result 47495 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakatani, Ayami| |
| Published Date | 2020-08-04 |
| Publication Title | American Ethnologist |
| Volume | volume47 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 343 |
| End Page | 344 |
| ISSN | 0094-0496 |
| NCID | AA0004824X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1111/amet.12946 |
| Web of Science KeyUT | 000555316400001 |
| Related Url | isVersionOf https://doi.org/10.1111/amet.12946 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shikata, Kenichi| Haneda, Masakazu| Ninomiya, Toshiharu| Koya, Daisuke| Suzuki, Yoshiki| Suzuki, Daisuke| Ishida, Hitoshi| Akai, Hiroaki| Tomino, Yasuhiko| Uzu, Takashi| Nishimura, Motonobu| Maeda, Shiro| Ogawa, Daisuke| Miyamoto, Satoshi| Makino, Hirofumi| the Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) collaborative group| |
| Keywords | Diabetic kidney disease Diabetic nephropathy Diabetic Nephropathy Remission and Regression Team Trial in Japan |
| Published Date | 2020-08-08 |
| Publication Title | Journal of Diabetes Investigation |
| Volume | volume12 |
| Issue | issue2 |
| Publisher | Wiley |
| Start Page | 207 |
| End Page | 216 |
| ISSN | 2040-1116 |
| NCID | AA12488319 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors |
| File Version | publisher |
| PubMed ID | 32597548 |
| NAID | 120006880216 |
| DOI | 10.1111/jdi.13339 |
| Web of Science KeyUT | 000557091100001 |
| Related Url | isVersionOf https://doi.org/10.1111/jdi.13339 |
| JaLCDOI | 10.18926/AMO/60376 |
|---|---|
| FullText URL | 74_4_365.pdf |
| Author | Chuma, Masayuki| Kondo, Masateru| Zamami, Yoshito| Takechi, Kenshi| Goda, Mitsuhiro| Okada, Naoto| Shibata, Akitomo| Asada, Mizuho| Oto, Jun| Yanagawa, Hiroaki| Ishizawa, Keisuke| |
| Abstract | Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function. |
| Keywords | vancomycin, therapeutic drug monitoring cystatin C bacterial meningitis sepsis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 365 |
| End Page | 370 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843769 |
| Web of Science KeyUT | 000562508700013 |
| NAID | 120006880215 |
| JaLCDOI | 10.18926/AMO/60375 |
|---|---|
| FullText URL | 74_4_359.pdf |
| Author | Inaba, Mototaka| Naito, Hiromichi| Muramatsu, Tomoyoshi| Yamada, Taihei| Sakata, Taizo| Nakao, Atsunori| |
| Abstract | During major flooding in June/July 2018, the Mabi Memorial Hospital in Kurashiki, Okayama, Japan was flooded and patients were stranded in the hospital. Peace Winds Japan, a non-governmental organization, collaborated with the Japanese Disaster Medical Assistance Team and Self-Defense Force Public to transport 8 critical patients from the hospital by helicopter. Ultimately, 54 patients and hospital staff members were safely evacuated. The evacuation was accomplished without any casualties, despite the severe conditions. Public and private organizations can work together and continue to seek ways to collaborate and cooperate in disaster settings. |
| Keywords | natural disaster transportation rain relief work public-private sector partnerships |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 364 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843768 |
| Web of Science KeyUT | 000562508700012 |
| NAID | 120006880214 |
| JaLCDOI | 10.18926/AMO/60374 |
|---|---|
| FullText URL | 74_4_351.pdf |
| Author | Utsumi, Masashi| Aoki, Hideki| Yabuki, Takayuki| Nagahisa, Seiichi| Nishimura, Seitaro| Une, Yuta| Kimura, Yuji| Watanabe, Megumi| Taniguchi, Fumitaka| Arataa, Takashi| Katsuda, Koh| Tanakaya, Kohji| Sato, Yumiko| |
| Abstract | Post-operative pancreatic fistula (POPF) remains the most common complication after distal pancreatectomy (DP). In this retrospective study, we reviewed the data from patients who underwent DP between 2008 and 2019 in our institute to determine whether the late phase/early phase ratio (L/E ratio) by preoperative computed tomography (CT) scan in the pancreas could predict POPF occurrence after DP. We examined the relationship between preoperative or intraoperative factors and the occurrence of POPF after DP using statistical methods in 23 males and 21 females with a mean age of 73. The mean L/E ratio was significantly lower in the POPF group than the non-POPF group (p=0.035). The L/E ratio had moderate diagnostic accuracy, with a calculated optimal cutoff value of 0.77. In univariate analysis, a significant association was noted between POPF and stump thickness ≥ 16.9, body mass index ≥ 27.5, and L/E ratio ≤ 0.77. In the multivariate analysis, the L/E ratio (odds ratio, 5.96; p=0.036) was an independent risk factor for POPF. Our findings suggest that the pancreatic L/E ratio may predict the occurrence of POPF after DP. This measure may be useful in preoperative risk stratification, patient counseling, and perioperative patient management, improving clinical outcomes after DP. |
| Keywords | late phase/early phase ratio pancreatic fistula distal pancreatectomy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 351 |
| End Page | 358 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843767 |
| Web of Science KeyUT | 000562508700011 |
| NAID | 120006880213 |
| JaLCDOI | 10.18926/AMO/60373 |
|---|---|
| FullText URL | 74_4_345.pdf |
| Author | Tanaka, Takaaki| Furumatsu, Takayuki| Hiranaka, Takaaki| Okazaki, Yuki| Masudaa, Kenji| Senoa, Noritaka| Ozaki, Toshifumi| |
| Abstract | The aim of this study was to evaluate tunnel coalition and inter-tunnel distance by comparing the tibial tunnel position in double-bundle anterior cruciate ligament (ACL) reconstruction performed with a conventional guide versus a posterolateral (PL) divergence (PLD) guide. Subjects were 43 patients (ACL tip aimer: 20 knees; PLD guide: 23 knees) who underwent double-bundle ACL reconstruction between September 2014 and December 2017. In all cases, the tibial tunnel position, tunnel edge distance and tunnel angles were evaluated based on CT images. Clinical outcome was evaluated using the Lachman test, pivot-shift test, and Lysholm score. Tibial tunnel positions were similar between the conventional and PLD guide groups, while tibial tunnel edge distance was significantly less in the conventional group. Tunnel coalition was observed in 5 knees in the conventional and no knees in the PLD guide group. Distance between two tibial tunnel centers was 9.1 mm for the tip aimer, and 10.5 mm for the PLD guide. Creation of the PL tunnel tended to involve insertion from a more medial aspect for the PLD guide group than the conventional guide group. No differences in clinical outcomes were noted. The PLD guide can be used to create anatomically-positioned PL tunnels, and reduce the probability of occurrence of tunnel coalition. |
| Keywords | anterior cruciate ligament reconstruction tibial tunnel position PL divergence guide tunnel coalition |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 345 |
| End Page | 350 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843766 |
| Web of Science KeyUT | 000562508700010 |
| NAID | 120006880212 |
| JaLCDOI | 10.18926/AMO/60372 |
|---|---|
| FullText URL | 74_4_335.pdf |
| Author | Yamamoto, Yumiko| Hayashi, Yoshihiro| Murakami, Ichiro| |
| Abstract | Since the discovery of the NAB2-STAT6 gene fusion in 2013, solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) have been considered the same disease. STAT6 nuclear stain is approved as a highly sensitive and specific marker to diagnose SFT/HPC from other tumors with similar histology. As the next step, detection of fusion variants that may predict clinical malignancy of SFT/HPC has been attempted. However, no fusion variants with a clear relation to malignancy have been identified. In this study, the clinical and histological backgrounds of 23 Japanese patients diagnosed with SFT/HPC from 2000 to 2019 at Kochi University Hospital were examined to identify factors potentially related to recurrence. A significant relationship to recurrence was detected for mitosis ≥ 1/10 HPF (400×), necrosis, and Ki-67>5%. These findings indicate that a deliberate investigation of histological features such as mitosis and necrosis is crucial for the clinical observation of SFT/ HPC patients. In addition, Ki-67 was revealed to be a useful parameter to predict recurrence in SFT/HPC patients. |
| Keywords | solitary fibrous tumor hemangiopericytoma Ki-67 NAB2-STAT6 WHO classification WHO grading criteria Marseille Grading System |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 335 |
| End Page | 343 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843765 |
| Web of Science KeyUT | 000562508700009 |
| NAID | 120006880211 |
| JaLCDOI | 10.18926/AMO/60371 |
|---|---|
| FullText URL | 74_4_327.pdf |
| Author | Yamamoto, Ken-ichi| Kagawa, Hiroko| Arimoto, Sakae| Tan, Xian Wen| Yasui, Kento| Oshiki, Toshiyuki| Sakaguchi, Masakiyo| |
| Abstract | An increasing accumulation of microplastics and further degraded nanoplastics in our environment is suspected to have harmful effects on humans and animals. To clarify this problem, we tested the cytotoxicity of two types of plastic wrap on human cultured liver cells and mouse primary cultured liver cells. Alcohol extracts from plastic wrap, i.e., polyvinylidene chloride (PVDC), showed cytotoxic effects on the cells. Alcohol extracts of polyethylene (PE) wrap were not toxic. The commercially available PVDC wrap consists of vinylidene chloride, epoxidized soybean oil, epoxidized linseed oil as a stiffener and stabilizer; we sought to identify which component(s) are toxic. The epoxidized soybean oil and epoxidized linseed oil exerted strong cytotoxicity, but the plastic raw material itself, vinylidene chloride, did not. Our findings indicate that plastic wraps should be used with caution in order to prevent health risks. |
| Keywords | plastic wrap plasticizer, cytotoxicity, liver cells in vitro |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 327 |
| End Page | 334 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843764 |
| Web of Science KeyUT | 000562508700008 |
| NAID | 120006880210 |
| JaLCDOI | 10.18926/AMO/60370 |
|---|---|
| FullText URL | 74_4_319.pdf |
| Author | Isoyama, Satoshi| Kimura, Satoshi| Morimatsu, Hiroshi| |
| Abstract | Little is known about the role of a strong ions in humans with respiratory abnormalities. In this study, we investigated the associations between partial carbon dioxide pressure (pCO2) and each of sodium ion (Na+) concentrations, chloride ion (Cl−) concentrations and their difference (SIDNa-Cl). Blood gas data were obtained from patients in a teaching hospital intensive care unit between August 2013 and January 2017. The association between pCO2 and SIDNa-Cl was defined as the primary outcome. The associations between pCO2 and [Cl−], [Na+] and other strong ions were secondary outcomes. pCO2 was stratified into 10 mmHg-wide bands and treated as a categorical variable for comparison. As a result, we reviewed 115,936 blood gas data points from 3,840 different ICU stays. There were significant differences in SIDNa-Cl, [Cl−], and [Na+] among all categorized pCO2 bands. The respective pCO2 SIDNa-Cl, [Cl−], and [Na+] correlation coefficients were 0.48, −0.31, and 0.08. SIDNa-Cl increased and [Cl−] decreased with pCO2, with little relationship between pCO2 and [Na+] across subsets. In conclusion, we found relatively strong correlations between pCO2 and SIDNa-Cl in the multiple blood gas datasets examined. Correlations between pCO2 and chloride concentrations, but not sodium concentrations, were further found to be moderate in these ICU data. |
| Keywords | acid-base phenomena Stewart approach strong ion difference chlorine ion partial carbon dioxide pressure |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 319 |
| End Page | 325 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843763 |
| Web of Science KeyUT | 000562508700007 |
| NAID | 120006880209 |
| JaLCDOI | 10.18926/AMO/60369 |
|---|---|
| FullText URL | 74_4_307.pdf |
| Author | Nagamine, Yuichi| Hasibul, Khaleque| Ogawa, Takaaki| Tada, Ayano| Kamitori, Kazuyo| Hossain, Akram| Yamaguchi, Fuminori| Tokuda, Masaaki| Kuwahara, Tomomi| Miyake, Minoru| |
| Abstract | We examined the effect of D-Tagatose on the growth of oral bacteria including Streptococcus mutans (S. mutans). Saliva collected from 10 healthy volunteers was plated on BHI medium (to culture total oral bacteria) and MBS medium (to culture S. mutans, specifically). Agar plates of BHI or MBS containing xylitol or D-Tagatose were cultured under aerobic or anaerobic conditions. We then counted the number of colonies. In BHI plates containing D-Tagatose, a complete and significant reduction of bacteria occurred under both aerobic and anaerobic conditions. In MSB medium, significant reduction of S. mutans was also observed. We then performed a doubleblind parallel randomized trial with 19 healthy volunteers. They chewed gum containing xylitol, D-Tagatose, or both for 4 weeks, and their saliva was collected weekly and plated on BHI and MSB media. These plates were cultured under anaerobic conditions. Total bacteria and S. mutans were not effectively reduced in either the D-Tagatose or xylitol gum group. However, S. mutans was significantly reduced in volunteers chewing gum containing both D-Tagatose and xylitol. Thus, D-Tagatose inhibited the growth of S. mutans and many types of oral bacteria, indicating that D-Tagatose intake may help prevent dental caries, periodontitis, and many oral diseases. |
| Keywords | D-Tagatose xylitol Streptococcus mutans oral bacteria chewing gum |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 307 |
| End Page | 317 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843762 |
| Web of Science KeyUT | 000562508700006 |
| NAID | 120006880208 |
| reference | Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C and Ezzati M et al.: Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 380: 2163-2196.| Sawada D, Ogawa T, Miyake M, Hasui Y, Yamaguchi F, Izumori K and Tokuda M: Potent inhibitory effects of D-Tagatose on the acid production and water-insoluble glucan synthesis of Streptococcus mutans GS5 in the presence of sucrose. Acta Med Okayama (2015) 69: 105-111. doi: 10.18926/AMO/53339.| Tada A, Nakayama-Imaohji H, Yamasaki H, Hasibul K, Yoneda S, Uchida K, Nariya H, Suzuki M, Miyake M and Kuwahara T: Cleansing effect of acidic L-arginine on human oral biofilm. BMC Oral Health (2016) 16: 40.| Scheinin A, Mäkinen KK, Tammisalo E and Rekola M: Turku sugar studies XVIII. Incidence of dental caries in relation to 1-year consumption of xylitol chewing gum. Acta Odontol Scand (1975) 33: 269-278.| Larmas M, Scheinin A, Gehring F and Mäkinen KK: Turku sugar studies XX. Microbiological findings and plaque index values in relation to 1-year use of xylitol chewing gum. Acta Odontol Scand (1976) 34: 381-396.| Söderling E, ElSalhy M, Honkala E, Fontana M, Flannagan S, Eckert G, Kokaras A, Paster B, Tolvanen M and Honkala S: Effects of short-term xylitol gum chewing on the oral microbiome. Clin Oral Investig (2015) 19: 237-244.| Seki M, Karakama F, Kawato T, Tanaka H, Saeki Y and Yamashita Y: Effect of xylitol gum on the level of oral mutans streptococci of preschoolers: Block-randomised trial. Int Dent J (2011) 61: 274-280. doi: 10.1111/j. 1875-595X.2011.00073.x.| Hashiba T, Takeuchi K, Shimazaki Y, Takeshita T and Yamashita Y: Chewing xylitol gum improves self-rated and objective indicators of oral health status under conditions interrupting regular oral hygiene. Tohoku J Exp Med (2015) 235: 39-46. doi: 10.1620/tjem.235.39.| Rösing CK, Gomes SC, Bassani DG and Oppermann RV: Effect of chewing gums on the production of volatile sulfur compounds (VSC) in vivo. Acta Odontol Latinoam (2009) 22: 11-14.| Tao DY, Shu CB, Lo EC, Lu HX and Feng XP: A randomized trial on the inhibitory effect of chewing gum containing tea polyphenol on caries. J Clin Pediatr Dent (2013) 38: 67-70.| Girardot M, Guerineau A, Boudesocque L, Costa D, Bazinet L, Enguehard-Gueiffier C and Imbert C: Promising results of cranberry in the prevention of oral Candida biofilms. Pathog Dis (2014) 70: 432-439. doi: 10.1111/2049-632X.12168.| Rahman MA and Islam MS: Xylitol improves pancreatic islets morphology to ameliorate type 2 diabetes in rats: A dose response study. J Food Sci (2014) 79: H1436-H1442. doi: 10.1111/1750-3841.12520.| Mickenautsch S, Leal SC, Yengopal V, Bezerra AC and Cruvinel V: Sugar-free chewing gum and dental caries: A systematic review. J Appl Oral Sci (2007) 15: 83-88.| Deshpande A and Jadad AR: The impact of polyol-containing chewing gums on dental caries: A systematic review of original randomized controlled trials and observational studies. J Am Dent Assoc (2008) 139: 1602-1614.| Riley P, Moore D, Ahmed F, Sharif MO and Worthington HV: Xylitol-containing products for preventing dental caries in children and adults. Cochrane Database Syst Rev (2015) 3: CD010743.| Keukenmeester RS, Slot DE, Rosema NA, Van Loveren C and Van der Weijden GA: Effects of sugar-free chewing gum sweetened with xylitol or maltitol on the development of gingivitis and plaque: A randomized clinical trial. Int J Dent Hyg (2014) 12: 238-244.| Tanner AC: Anaerobic culture to detect periodontal and caries pathogens. J Oral Biosci (2015) 57: 18-26. doi: 10.1016/j.job.2014.08.001| Loesche W. J: Role of Streptococcus mutans in human dental decay. Microbiol Rev (1986) 50: 353-380.| Steinberg LM, Odusola F and Mandel ID: Remineralizing potential, antiplaque and antigingivitis effects of xylitol and sorbitol sweetened chewing gum. Clin Prev Dent (1992) 14: 31-34.| Gueimonde L, Vesterlund S, García-Pola MJ, Gueimonde M, Söderling E and Salminen S: Supplementation of xylitol-containing chewing gum with probiotics: A double blind, randomised pilot study focusing on saliva flow and saliva properties. Food Funct (2016) 7: 1601-1609.| Ogawa T, Waki J, Tada A, Yoneda S, Tokuda M, Miyake M and Kuwahara T: D-Tagatose inhibits the growth and biofilm formation of Streptococcus mutans. Mol Med Rep (2018) 17: 843-851.| Haghgoo R, Afshari E, Ghanaat T and Aghazadeh S: Comparing the efficacy of xylitol-containing and conventional chewing gums in reducing salivary counts of Streptococcus mutans: An in vivo study. J Int Soc Prev Community Dent (2015) 5(Suppl 2): S112-S117.| |
| JaLCDOI | 10.18926/AMO/60368 |
|---|---|
| FullText URL | 74_4_301.pdf |
| Author | Takahashi, Kei| Kitamura, Yoshihisa| Ushio, Soichiro| Sendo, Toshiaki| |
| Abstract | Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear. We examined the effects of ketamine on the immobility times of adrenocorticotropic hormone (ACTH)-treated rats during the forced swim test, and we explored the mechanism by which ketamine acts in this model. We investigated the neuroanatomical site of action by microinjecting ketamine into the medial prefrontal cortex of rats. A significant reduction of the rats’ immobility during the forced swim test was observed after the intraperitoneal injection of ketamine in both saline- and ACTH-treated rats. The microinjection of ketamine into the medial prefrontal cortex also decreased immobility during the forced swim test in both saline- and ACTH-treated rats. The immobility-decreasing effect of intraperitoneally injected ketamine was blocked by administering WAY100635, a 5-HT1A receptor antagonist, into the medial prefrontal cortex. These findings contribute to the evidence that ketamine can be useful against treatment-resistant depressive conditions. The immobility-reducing effects of ketamine might be mediated by 5-HT1A receptor activity in the medial prefrontal cortex. |
| Keywords | ketamine adrenocorticotropic hormone forced swim test medial prefrontal cortex 5-HT1A receptor |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 301 |
| End Page | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843761 |
| Web of Science KeyUT | 000562508700005 |
| NAID | 120006880207 |
| JaLCDOI | 10.18926/AMO/60367 |
|---|---|
| FullText URL | 74_4_293.pdf |
| Author | Yoshioka, Takashi| Omae, Kenji| Kawada, Tatsushi| Inoue, Yosuke| Sugimoto, Morito| Oeda, Tadashi| Uehara, Shinya| Araki, Motoo| Fukuhara, Shunichi| |
| Abstract | In this retrospective single-center cohort study, we investigated the impact of preoperative use of an alpha-1 adrenergic receptor (AR) blocker on the outcome of single-session extracorporeal shock wave lithotripsy (SWL) in 193 male patients who underwent SWL for a single ureteral calculus between 2006 and 2016. We reviewed their medical records to obtain the data on the preoperative use of alpha-1 AR blockers. The primary outcome was treatment success after single-session SWL. We performed a multivariable logistic regression analysis adjusting for clinically important confounders to examine the association between preoperative use of alpha-1 AR blockers and the treatment success of SWL. Among the 193 patients, 15 (7.8%) were taking an alpha-1 AR blocker preoperatively. A multivariable analysis showed that preoperative use of an alpha-1 AR blocker was a significant negative predictor for treatment success of SWL (adjusted odds ratio 0.17; 95% confidence intervals, 0.04-0.74). Our findings suggest that the preoperative use of an alpha-1 AR blocker was a negative predictor of treatment success of SWL in male patients with a single ureteral calculus. Clinicians should pay more attention to the preoperative drug use in determining an appropriate stone therapy modality. |
| Keywords | urolithiasis extracorporeal shockwave therapy adrenergic alpha-1 receptor antagonists |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 293 |
| End Page | 299 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843760 |
| Web of Science KeyUT | 000562508700004 |
| NAID | 120006880206 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kitamura, Shinji| Takahashi, Kensaku| Sang, Yizhen| Fukushima, Kazuhiko| Tsuji, Kenji| Wada, Jun| |
| Keywords | immunofluorescent image renal pathology artificial intelligence deep learning diabetic nephropathy |
| Published Date | 2020-07-09 |
| Publication Title | Diagnostics |
| Volume | volume10 |
| Issue | issue7 |
| Publisher | MDPI |
| Start Page | 466 |
| ISSN | 2075-4418 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32660112 |
| DOI | 10.3390/diagnostics10070466 |
| Web of Science KeyUT | 000557155500001 |
| Related Url | isVersionOf https://doi.org/10.3390/diagnostics10070466 |
| JaLCDOI | 10.18926/AMO/60365 |
|---|---|
| FullText URL | 74_4_285.pdf |
| Author | Tsukahara, Kohei| Naitou, Hiromichi| Yorifuji, Takashi| Nosaka, Nobuyuki| Yamamoto, Hirotsugu| Osako, Takaaki| Nakao, Atsunori| the JaRPAC Study Group| |
| Abstract | The importance of centralizing treatment services for severely ill children has been well established, but such entralization remains difficult in Japan. We aimed to compare the trauma and illness severity and mortality of children admitted to two common types of ICUs for children. According to the type of management and disposition of the medical provider, we classified ICUs as pediatric ICUs [PICUs] or general ICUs, and analyzed differences in endogenous and exogenous illness settings between them. Overall, 1,333 pediatric patients were included, with 1,143 patients admitted to PICUs and 190 patients to general ICUs. The Pediatric Cerebral Performance Category score (PCPC) at discharge was significantly lower in the PICU group (adjusted OR: 0.45; 95%CI: 0.23-0.88). Death and unfavorable neurological outcomes occurred less often in the PICU group (adjusted OR: 0.29; 95%CI: 0.14-0.60). However, when limited to exogenous illness, PCPC scores (adjusted OR: 0.38; 95%CI: 0.07-1.99) or death/unfavorable outcomes (adjusted OR: 0.72; 95%CI: 0.08-6.34) did not differ between the groups. PCPC deterioration and overall sequelae/death rates were lower in PICUs for children with endogenous illnesses, although the outcomes of exogenous illness were similar between the 2 unit types. Further studies on the necessity of centralization are warranted. |
| Keywords | kids critical care mortality morbidity centralization |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 291 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843759 |
| Web of Science KeyUT | 000562508700003 |
| NAID | 120006880204 |
| JaLCDOI | 10.18926/AMO/60364 |
|---|---|
| FullText URL | 74_4_275.pdf |
| Author | Muro, Taiko| Nakamura, Shinichiro| Takaki, Akinobu| Onishi, Hideki| Wada, Nozomu| Yasunaka, Tetsuya| Uchida, Daisuke| Oyama, Atsushi| Adachi, Takuya| Shiraha, Hidenori| Okada, Hiroyuki| |
| Abstract | Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment. |
| Keywords | oxidative stress hepatocellular carcinoma recurrence, radiofrequency ablation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 275 |
| End Page | 283 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843758 |
| Web of Science KeyUT | 000562508700002 |
| NAID | 120006880203 |
| JaLCDOI | 10.18926/AMO/60363 |
|---|---|
| FullText URL | 74_4_265.pdf |
| Author | Inokuchi, Toshihiro| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahar, Masahiro| Kawano, Seiji| Harada, Keita| Okada, Hiroyuki| Kato, Jun| |
| Abstract | Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy. |
| Keywords | Crohn’s disease anti-TNF agent upper gastrointestinal lesion bamboo joint-like appearance |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 265 |
| End Page | 274 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843757 |
| Web of Science KeyUT | 000562508700001 |
| NAID | 120006880202 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamashiro, Keisuke| Ideguchi, Hidetaka| Aoyagi, Hiroaki| Yoshihara-Hirata, Chiaki| Hirai, Anna| Suzuki-Kyoshima, Risa| Zhang, Yao| Wake, Hidenori| Nishibori, Masahiro| Yamamoto, Tadashi| Takashiba, Shogo| |
| Keywords | high mobility group box 1 inflammation periodontal regeneration periodontitis osseointegration tooth movement wound healing |
| Published Date | 2020-07-14 |
| Publication Title | Frontiers in Immunology |
| Volume | volume11 |
| Publisher | Frontiers Media |
| Start Page | 1461 |
| ISSN | 1664-3224 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Yamashiro et al. |
| File Version | publisher |
| PubMed ID | 32760399 |
| DOI | 10.3389/fimmu.2020.01461 |
| Web of Science KeyUT | 000556581900001 |
| Related Url | isVersionOf https://doi.org/10.3389/fimmu.2020.01461 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Morikawa, Yuko| Morimoto, Setsuyo| Yoshida, Eri| Naka, Shuhei| Inaba, Hiroaki| Matsumoto-Nakano, Michiyo| |
| Keywords | Streptococcus mutans glutamine transporter biofilm membrane protein glnP |
| Published Date | 2020-08-04 |
| Publication Title | Journal of Oral Microbiology |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Taylor & Francis |
| Start Page | 1797320 |
| ISSN | 2000-2297 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Author(s). |
| File Version | publisher |
| DOI | 10.1080/20002297.2020.1797320 |
| Web of Science KeyUT | 000555592200001 |
| Related Url | isVersionOf https://doi.org/10.1080/20002297.2020.1797320 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nanki, Yoshiko| Chiyoda, Tatsuyuki| Hirasawa, Akira| Ookubo, Aki| Itoh, Manabu| Ueno, Masaru| Akahane, Tomoko| Kameyama, Kaori| Yamagami, Wataru| Kataoka, Fumio| Aoki, Daisuke| |
| Published Date | 2020-07-28 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature |
| Start Page | 12581 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32724113 |
| DOI | 10.1038/s41598-020-69488-9 |
| Web of Science KeyUT | 000556398500004 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-69488-9 |
| FullText URL | 48_320.pdf |
|---|---|
| Author | Yumoto, Yasuhiro| Hanafusa, Tadashi| Nagamatsu, Tomohiro| Okada, Shigeru| |
| Keywords | low level radioactive sample (LLRS) low energy β-emitter Imaging Plate experimental incineration system |
| Published Date | 1999-05-15 |
| Publication Title | Radioisotopes |
| Volume | volume48 |
| Issue | issue5 |
| Publisher | 日本アイソトープ協会 |
| Start Page | 320 |
| End Page | 326 |
| ISSN | 00338303 |
| NCID | AN00351589 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| NAID | 10002684844 |
