| ID | 17060 |
| Eprint ID | 17060
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| FullText URL | |
| Title Alternative | Immunological studies on lupus nephritis Part 2. Studies on glomerular deposition of C(1)q
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| Author |
Tarumi, Yoshinao
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| Abstract | C(1)q, the first component of C(1), was isolated from normal human sera according to Thunild's method. Specific antibody to C(1)q was produced in rabbits. Fluorescein isothiocyanate (FITC) was labelled on the antibody. Renal tissues from 35 patients with systemic lupus erythematosus (SLE) were stained with FITC labelled antibody to C(1)q as well as C(3), IgG, IgM and IgA. The following results were obtained. 1. Glomerular deposition of C(1)q was frequently seen in patients who had massive deposition of immunoglobulins and C(3) along the glomerular basement membrane. The distribution of C(1)q is similar to that of immunoglobulins and C(3). 2. Positive C(1)q deposition on glomeruli was associated with low levels of serum C(1)q and the presence of complement fixing antibody to native DNA. 3. Serial renal biopsy of 15 patients with SLE showed that a marked decrease of C(1)q deposition was observed after steroid therapy. These results indicate that glomerular deposition of C(1)q is of importance to evaluate the clinical and immunopathological activity of lupus nephritis.
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| Keywords | ループス腎炎
C(1)q
CF-n-DNA 抗体
Cg
immune complex
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| Published Date | 1980-06-30
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume92
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| Issue | issue5-6
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 587
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| End Page | 595
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/92/5-6/92_5-6_587/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
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