result 1347 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ujita, Hitomi| Higuchi, Hitoshi| Nishioka, Yukiko| Miyake, Saki| Sato, Riko| Miyawaki, Takuya| |
| Keywords | liposome propofol bioavailability intranasal administration |
| Published Date | 2025-11-09 |
| Publication Title | Pharmaceutics |
| Volume | volume17 |
| Issue | issue11 |
| Publisher | MDPI AG |
| Start Page | 1446 |
| ISSN | 1999-4923 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| DOI | 10.3390/pharmaceutics17111446 |
| Related Url | isVersionOf https://doi.org/10.3390/pharmaceutics17111446 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamazaki, Ken| Akimoto, Shuta| Miura, Tomoya| |
| Published Date | 2025 |
| Publication Title | Organic & Biomolecular Chemistry |
| Volume | volume23 |
| Issue | issue43 |
| Publisher | Royal Society of Chemistry (RSC) |
| Start Page | 9936 |
| End Page | 9941 |
| ISSN | 1477-0520 |
| NCID | AA1168650X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Royal Society of Chemistry 2025 |
| File Version | publisher |
| PubMed ID | 40512134 |
| DOI | 10.1039/d5ob00675a |
| Web of Science KeyUT | 001507651000001 |
| Related Url | isVersionOf https://doi.org/10.1039/d5ob00675a |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawai, Hiroki| Wada, Nanami| Sakamoto, Shinji| Miyazaki, Kenji| Kato, Taro| Horiuchi, Yoshihiro| Kirii, Hiroshi| Nguyen, Hoang Duy| Hinotsu, Kenji| Ohya, Yoshio| Asada, Takahiro| Yokode, Akiyoshi| Okahisa, Yuko| Miyazaki, Haruko| Oohashi, Toshitaka| Takaki, Manabu| |
| Keywords | 11β-HSD1 activity-based anorexia anorexia nervosa corticosterone eating disorders microbiota |
| Published Date | 2025-09-24 |
| Publication Title | International Journal of Eating Disorders |
| Publisher | Wiley |
| ISSN | 0276-3478 |
| NCID | AA10627028 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 40990870 |
| DOI | 10.1002/eat.24557 |
| Web of Science KeyUT | 001577518500001 |
| Related Url | isVersionOf https://doi.org/10.1002/eat.24557 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Watanabe, Mayu| Eguchi, Jun| Kurooka, Naoko| Eto, Eriko| Masuyama, Hisashi| Wada, Jun| |
| Keywords | glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) gestational diabetes mellitus (GDM) perinatal outcomes placenta triglyceride (TG) |
| Published Date | 2025-10-10 |
| Publication Title | Frontiers in Clinical Diabetes and Healthcare |
| Volume | volume6 |
| Publisher | Frontiers Media SA |
| Start Page | 1682012 |
| ISSN | 2673-6616 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Watanabe, Eguchi, Kurooka, Eto, Masuyama and Wada. |
| File Version | publisher |
| PubMed ID | 41142641 |
| DOI | 10.3389/fcdhc.2025.1682012 |
| Web of Science KeyUT | 001599396300001 |
| Related Url | isVersionOf https://doi.org/10.3389/fcdhc.2025.1682012 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakanoh, Hiroyuki| Tsuji, Kenji| Fukushima, Kazuhiko| Uchida, Naruhiko| Haraguchi, Soichiro| Kitamura, Shinji| Wada, Jun| |
| Keywords | kidney organoid stem cell disease modeling drug toxicity drug screening regenerative medicine |
| Published Date | 2025-10-29 |
| Publication Title | Life |
| Volume | volume15 |
| Issue | issue11 |
| Publisher | MDPI AG |
| Start Page | 1680 |
| ISSN | 2075-1729 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| DOI | 10.3390/life15111680 |
| Related Url | isVersionOf https://doi.org/10.3390/life15111680 |
| FullText URL | fulltext.pdf suppl1.pdf suppl2.docx suppl3.xlsx |
|---|---|
| Author | Tanaka, Tsuyoshi| Haraguchi, Yuhi| Todoroki, Takatomo| Saisho, Daisuke| Abiko, Tomomi| Kai, Hiroomi| |
| Keywords | Hordeum vulgare genome sequencing long-read sequencing |
| Published Date | 2025-06-19 |
| Publication Title | DNA Research |
| Volume | volume32 |
| Issue | issue4 |
| Publisher | Oxford University Press (OUP) |
| Start Page | dsaf016 |
| ISSN | 1340-2838 |
| NCID | AA11095219 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025. |
| File Version | publisher |
| PubMed ID | 40577690 |
| DOI | 10.1093/dnares/dsaf016 |
| Web of Science KeyUT | 001523410800001 |
| Related Url | isVersionOf https://doi.org/10.1093/dnares/dsaf016 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hemelda, Niarsi Merry| Noutoshi, Yoshiteru| |
| Keywords | carbon sources plant-derived sugars plant-microbe interactions rhizosphere root exudate |
| Published Date | 2025-09-25 |
| Publication Title | Plant Biotechnology |
| Volume | volume42 |
| Issue | issue3 |
| Publisher | Japanese Society for Plant Cell and Molecular Biology |
| Start Page | 215 |
| End Page | 227 |
| ISSN | 1342-4580 |
| NCID | AA11250821 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Japanese Society for Plant Biotechnology. |
| File Version | publisher |
| DOI | 10.5511/plantbiotechnology.25.0214a |
| Related Url | isVersionOf https://doi.org/10.5511/plantbiotechnology.25.0214a |
| JaLCDOI | 10.18926/AMO/69438 |
|---|---|
| FullText URL | 79_5_369.pdf |
| Author | Hisamatsu, Takashi| Kinuta, Minako| Munetomo, Sosuke| Fukuda, Mari| Kojima, Katsuhide| Taniguchi, Kaori| Nakahata, Noriko| Kanda, Hideyuki| |
| Abstract | We applied unsupervised machine learning to analyze blood pressure (BP) and resting heart rate (HR) patterns measured during a 1-year period to assess their cross-sectional relationships with subclinical cerebral and renal target damage. Dimension reduction via uniform manifold approximation and projection, followed by K-means++ clustering, was used to categorize 362 community-dwelling participants (mean age, 56.2 years; 54.9% women) into three groups: Low BP and Low HR (Lo-BP/Lo-HR), High BP and High HR (Hi-BP/Hi-HR), and Low BP and High HR (Lo-BP/Hi-HR). Cerebral vessel lesions were defined as the presence of at least one of the following magnetic resonance imaging findings: lacunar infarcts, white matter hyperintensities, cerebral microbleeds, or intracranial artery stenosis. A high urinary albumin-to-creatinine ratio (UACR) was defined as the top 10% (≥ 12 mg/g) of the mean value from ≥2 measurements. Poisson regression with robust error variance, adjusted for demographics, lifestyle, and medical history, showed that the Hi-BP/Hi-HR group had relative risks of 3.62 (95% confidence interval, 1.75-7.46) for cerebral vessel lesions and 3.58 (1.33-9.67) for high UACR, and the Lo-BP/Hi-HR group had a relative risk of 3.09 (1.12-8.57) for high UACR, compared with the Lo-BP/Lo-HR group. These findings demonstrate the utility of an unsupervised, data-driven approach for identifying physiological patterns associated with subclinical target organ damage. |
| Keywords | blood pressure heart rate subclinical disease uniform manifold approximation and projection unsupervised machine learning |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-10 |
| Volume | volume79 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 369 |
| End Page | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/69435 |
|---|---|
| FullText URL | 79_5_345.pdf |
| Author | Matsunaga, Nozomu| Egusa, Seira| Aono, Riyo| Tamai, Eiji| Hitusmoto, Yasuo| Katayama, Seiichi| |
| Abstract | Clostridium perfringens is a pathogenic anaerobe that causes gas gangrene and food poisoning. Although autolysin-mediated reorganization of the bacterial cell wall is crucial for cell division, excessive autolysin activity induced by stressors can lead to cell lysis. In C. perfringens, air exposure is a significant stressor that causes cell lysis, and Acp (N-acetylglucosaminidase) is known to be a major autolysin. To further facilitate C. perfringens research, a technology to prevent air-induced cell lysis must be developed. This study investigated the role of Acp in air-induced autolysis and explored potential inhibitors that would prevent cell lysis during experimental procedures. Morphological analyses confirmed that Acp functions as an autolysin in C. perfringens, as acpdeficient strains exhibited filamentous growth. The mutants exhibited negligible autolysis under air-exposure stress, confirming the involvement of Acp in the autolytic process. We also evaluated the effects of various divalent cations on Acp activity in vitro and identified Zn2+ as a potent inhibitor. Brief treatment with a Zn2+- containing buffer induced dose-dependent cell elongation and autolysis inhibition in C. perfringens. These findings demonstrate that simple Zn2+ treatment before experiments stabilizes C. perfringens cells, reducing autolysis under aerobic conditions and facilitating various biological studies, except morphological analyses. |
| Keywords | Clostridium perfringens autolysin zinc air-exposure autolysis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-10 |
| Volume | volume79 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 345 |
| End Page | 352 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| FullText URL | fulltext.pdf suppl1.tiff suppl2.tiff suppl3.tiff |
|---|---|
| Author | Kubota-Takamori, Moyuka| Omori, Kazuhiro| Kamei-Nagata, Chiaki| Kiyama, Fumiko| Ishii, Takayuki| Nakayama, Masaaki| Gotoh, Kazuyoshi| Hirai, Kimito| Shinoda-Ito, Yuki| Okubo, Keisuke| Nakamura, Shin| Ikeda, Atsushi| Saito, Tsugumichi| Wada, Jun| Takashiba, Shogo| |
| Keywords | Continuous glucose monitoring Periodontal disease Insulin resistance Chronic inflammation Gut flora |
| Published Date | 2025-10-06 |
| Publication Title | Scientific Reports |
| Volume | volume15 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 34768 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 41053144 |
| DOI | 10.1038/s41598-025-18594-7 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-025-18594-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakamura, Kazufumi| Okumura, Takahiro| Kato, Seiya| Onoue, Kenji| Kubo, Toru| Kouzu, Hidemichi| Yano, Toshiyuki| Inomata, Takayuki| |
| Keywords | hypertrophic cardiomyopathy myosin inhibitors sarcomere mavacamten aficamten heart failure |
| Published Date | 2025-09-24 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume26 |
| Issue | issue19 |
| Publisher | MDPI AG |
| Start Page | 9347 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| DOI | 10.3390/ijms26199347 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms26199347 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Saito, Yukihiro| Nakamura, Kazufumi| Katanosaka, Yuki| Iida, Toshihiro| Kusumoto, Dai| Sato, Ryushi| Adachi, Riki| Shimizu, Satoshi| Kurokawa, Junko| Akagi, Satoshi| Yoshida, Masashi| Miyoshi, Toru| Morita, Hiroshi| Naruse, Keiji| Nishida, Mikako| Udono, Heiichiro| Zhang, Jianhua| Yuasa, Shinsuke| Kamp, Timothy J.| Ito, Hiroshi| |
| Keywords | Human pluripotent stem cell-derived cardiomyocytes Anterior second heart field Right ventricle Bone morphogenetic protein |
| Published Date | 2025-09-26 |
| Publication Title | Stem Cell Research & Therapy |
| Volume | volume16 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 519 |
| ISSN | 1757-6512 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025. |
| File Version | publisher |
| PubMed ID | 41013775 |
| DOI | 10.1186/s13287-025-04656-0 |
| Related Url | isVersionOf https://doi.org/10.1186/s13287-025-04656-0 |
| FullText URL | fulltext.pdf suppl1.pdf suppl2.xlsx |
|---|---|
| Author | Komuro, Jin| Hashimoto, Hisayuki| Katsuki, Toshiomi| Kusumoto, Dai| Katoh, Manami| Ko, Toshiyuki| Ito, Masamichi| Katagiri, Mikako| Kubota, Masayuki| Yamada, Shintaro| Nakamura, Takahiro| Akiba, Yohei| Kouka, Thukaa| Komuro, Kaoruko| Kimura, Mai| Ito, Shogo| Nomura, Seitaro| Komuro, Issei| Fukuda, Keiichi| Yuasa, Shinsuke| Ieda, Masaki| |
| Published Date | 2025-09-10 |
| Publication Title | Nature Cardiovascular Research |
| Volume | volume4 |
| Issue | issue9 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1135 |
| End Page | 1151 |
| ISSN | 2731-0590 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 40931092 |
| DOI | 10.1038/s44161-025-00698-y |
| Web of Science KeyUT | 001567654900001 |
| Related Url | isVersionOf https://doi.org/10.1038/s44161-025-00698-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Li, Qiwei| Li, Qiang| Xiao, Zhaoyang| NARUSE, Keiji| Takahashi, Ken| |
| Keywords | systemic lupus erythematosus (SLE) extracellular matrix (ECM) mechanotransduction mechanism immune regulation fibrosis organ-specific damage |
| Published Date | 2025-09-08 |
| Publication Title | AIMS Biophysics |
| Volume | volume12 |
| Issue | issue3 |
| Publisher | American Institute of Mathematical Sciences (AIMS) |
| Start Page | 412 |
| End Page | 437 |
| ISSN | 2377-9098 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 the Author(s), licensee AIMS Press. |
| File Version | publisher |
| DOI | 10.3934/biophy.2025020 |
| Related Url | isVersionOf https://doi.org/10.3934/biophy.2025020 |
| FullText URL | fulltext.pdf suppl.pdf |
|---|---|
| Author | Sun, Ruitong| Yano, Aina| Satoh, Ayano| Munemasa, Shintaro| Murata, Yoshiyuki| Nakamura, Toshiyuki| Nakamura, Yoshimasa| |
| Keywords | benzyl isothiocyanate multidrug resistance glutathione S-transferase NBDHEX apoptosis c-Jun N-terminal kinase |
| Published Date | 2025-08-22 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume26 |
| Issue | issue17 |
| Publisher | MDPI AG |
| Start Page | 8145 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| DOI | 10.3390/ijms26178145 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms26178145 |
| Title Alternative | The 2024 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2024 Sunada Prize) |
|---|---|
| Author | Nishihara, Takahiro| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2025-08-01 |
| Volume | volume137 |
| Issue | issue2 |
| Start Page | 43 |
| End Page | 45 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.137.43 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2025 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.137.43 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hirosuna, Kensuke| Kashima, Hajime| Shoji, Ryohei| Matsumi, Yuki| Kakiuchi, Yoshihiko| Kikuchi, Satoru| Kuroda, Shinji| Teraishi, Fuminori| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Keywords | obese patient gastric diverticulum sleeve gastrectomy metabolic surgery bariatric surgery endoscopic measurement |
| Published Date | 2025 |
| Publication Title | Surgical Case Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Japan Surgical Society |
| Start Page | cr.25-0141 |
| ISSN | 2198-7793 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 40511451 |
| DOI | 10.70352/scrj.cr.25-0141 |
| Web of Science KeyUT | 001533538200002 |
| Related Url | isVersionOf https://doi.org/10.70352/scrj.cr.25-0141 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sogawa, Chiharu| Shimada, Katsumitsu| Nakano, Keisuke| |
| Keywords | SLC transporter ABC transporter oral cancer oral squamous cell carcinoma |
| Published Date | 2025-05-01 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume26 |
| Issue | issue9 |
| Publisher | MDPI AG |
| Start Page | 4310 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 40362545 |
| DOI | 10.3390/ijms26094310 |
| Web of Science KeyUT | 001486433800001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms26094310 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakanoh, Hiroyuki| Takeuchi, Hidemi| Morimoto, Shiho| Terajima, Yuya| Okamoto, Shugo| Onishi, Yasuhiro| Tanaka, Keiko| Katsuyama, Takayuki| Tsuji, Kenji| Matsumoto, Yoshinori| Tanabe, Katsuyuki| Morinaga, Hiroshi| Uka, Mayu| Tomita, Koji| Uchida, Haruhito A.| Hiraki, Takao| Wada, Jun| |
| Keywords | rectus sheath hematoma microscopic polyangiitis hemodialysis |
| Published Date | 2024-12-01 |
| Publication Title | Internal Medicine |
| Volume | volume63 |
| Issue | issue23 |
| Publisher | Japanese Society of Internal Medicine |
| Start Page | 3243 |
| End Page | 3248 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by The Japanese Society of Internal Medicine |
| File Version | publisher |
| PubMed ID | 38658341 |
| DOI | 10.2169/internalmedicine.3239-23 |
| Web of Science KeyUT | 001389172700020 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.3239-23 |
| FullText URL | fulltext.pdf suppl.pdf |
|---|---|
| Author | Kawagoe, Soichiro| Matsusaki, Motonori| Mabuchi, Takuya| Ogasawara, Yuto| Watanabe, Kazunori| Ishimori, Koichiro| Saio, Tomohide| |
| Keywords | heat shock factor 1 oxidative hyper-oligomerization biological phase transition stress response biophysics |
| Published Date | 2025-01-30 |
| Publication Title | JACS Au |
| Volume | volume5 |
| Issue | issue2 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 606 |
| End Page | 617 |
| ISSN | 2691-3704 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Authors. |
| File Version | publisher |
| PubMed ID | 40017748 |
| DOI | 10.1021/jacsau.4c00578 |
| Web of Science KeyUT | 001411241900001 |
| Related Url | isVersionOf https://doi.org/10.1021/jacsau.4c00578 |
