result 1433 件
| Author | Katsuragi, Raijiro| |
|---|---|
| Published Date | 1935-12-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue12 |
| Content Type | Journal Article |
| Author | Katsuragi, Raijiro| |
|---|---|
| Published Date | 1935-11-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Katsuragi, Raijiro| |
|---|---|
| Published Date | 1935-11-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Sakai, Yosio| |
|---|---|
| Published Date | 1935-09-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue9 |
| Content Type | Journal Article |
| Author | Okazaki, Satoshi| |
|---|---|
| Published Date | 1935-08-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue8 |
| Content Type | Journal Article |
| Author | Takemoto, Iwao| |
|---|---|
| Published Date | 1935-07-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Hiraide, Shozo| |
|---|---|
| Published Date | 1935-07-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue7 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/45266 |
|---|---|
| FullText URL | 65_2_81.pdf |
| Author | Sasaki, Motofumi| Shikata, Kenichi| Okada, Shinichi| Miyamoto, Satoshi| Nishishita, Shingo| Usui Kataoka, Hitomi| Sato, Chikage| Wada, Jun| Ogawa, Daisuke| Makino, Hirofumi| |
| Abstract | Glomerular hyperfiltration is a common pathway leading to glomerulosclerosis in various kinds of kidney diseases. The 5/6 renal ablation is an established experimental animal model for glomerular hyperfiltration. On the other hand, low-grade inflammation is also a common mechanism for the progression of kidney diseases including diabetic nephropathy and atherosclerosis. Here we analyzed the gene expression profile in the remnant kidney tissues of 5/6 nephrectomized mice using a DNA microarray system and compared it with that of sham-operated control mice. The 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. DNA microarray analysis indicated the up-regulated expression of various kinds of genes related to the inflammatory process in remnant kidneys. We confirmed the up-regulated expression of platelet factor-4, and monocyte chemoattractant protein-1, 2, and 5 in remnant kidneys by RT-PCR. The current results suggest that the inflammatory process is involved in the progression of glomerulosclerosis and is a common pathway of the pathogenesis of kidney disease. |
| Keywords | kidney inflammation chemokine |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-04 |
| Volume | volume65 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 81 |
| End Page | 89 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21519365 |
| Web of Science KeyUT | 000289818800003 |
| Author | Hiraide, Shozo| |
|---|---|
| Published Date | 1935-06-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Hiraide, Shozo| |
|---|---|
| Published Date | 1935-05-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Hiraide, Shozo| |
|---|---|
| Published Date | 1935-05-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Ishijima, Tatsu| |
|---|---|
| Published Date | 1935-05-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Ohmori, So| |
|---|---|
| Published Date | 1935-04-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Suga, Tatsumasa| |
|---|---|
| Published Date | 1935-03-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Akaeda, Moriiti| |
|---|---|
| Published Date | 1935-01-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Akaeda, Moriiti| |
|---|---|
| Published Date | 1935-01-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume47 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Ishikawa, Hiroshi| |
|---|---|
| Published Date | 1937-11-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume49 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Wada, Masayuki| |
|---|---|
| Published Date | 1937-10-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume49 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Ito, M.| Nakamura, S.| |
|---|---|
| Published Date | 1937-10-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume49 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Ishido, H.| Kai, T.| |
|---|---|
| Published Date | 1937-08-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume49 |
| Issue | issue8 |
| Content Type | Journal Article |
