| ID | 40676 |
| FullText URL | |
| Title Alternative | Changes in and the significance of serum immunosuppressive substances (ISS) and NK activity in murine cardiac homotransplantation
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| Author |
Kimura, Takanobu
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| Abstract | Heterotopic homotransplantation of rat hearts was performed and ISS and NK activity levels were determined before and after rejection. The effects of prostaglandin (PGE(2)), cyclosporin A, and indomethacin on the acceptance of transplanted hearts as well as on ISS and NK activity were studied. PGE(2) and PGI(2) significantly extended survival when compared to a control group, while indomethacin decreased survival. ISS peaked 4 days before the rejection of transplanted hearts, suggesting its usefulness as a marker of rejection. Moreover, NK activity was significantly higher around the time of rejection, suggesting the importance of NK cells in this process. Finally, rejection was suppressed by administration of PGE(2).
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| Keywords | ラット心移植
ISS
NK細胞活性
プロスタグランジン
インドメサシン
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| Published Date | 1990-10
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume102
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| Issue | issue9-10
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 1083
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| End Page | 1090
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/102/9-10/102_9-10_1083/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
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