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JaLCDOI 10.18926/AMO/63205
FullText URL 76_1_25.pdf
Author Sugimoto, Kohei| Kuroda, Masahiro| Yoshimura, Yuuki| Hamada, Kentaro| Khasawneh, Abdullah| Barham, Majd| Tekiki, Nouha| Konishi, Kohei| Ishizaka, Hinata| Shimizu, Yudai| Nakamitsu, Yuki| Al-Hammad, Wlla E. | Kamizaki, Ryo| Kanazawa, Susumu| Asaumi, Junichi|
Abstract The apparent diffusion coefficient subtraction method (ASM) was developed as a new restricted diffusionweighted imaging technique for magnetic resonance imaging (MRI). The usefulness of the ASM has been established by in vitro basic research using a bio-phantom, and clinical research on the application of the ASM for the human body is needed. Herein, we developed a short-time sequence for ASM imaging of the heads of healthy volunteers (n=2), and we investigated the similarity between the obtained ASM images and diffusion kurtosis (DK) images to determine the utility of the ASM for clinical uses. This study appears to be the first to report ASM images of the human head. We observed that the short-time sequence for the ASM imaging of the head can be scanned in approx. 3 min at 1.5T MRI. The noise reduction effect of median filter processing was confirmed on the ASM images scanned by this sequence. The obtained ASM images showed a weak correlation with the DK images, indicating that the ASM images are restricted diffusion-weighted images. The new shorttime imaging sequence could thus be used in clinical studies applying the ASM.
Keywords apparent diffusion coefficient apparent diffusion coefficient subtraction method diffusion kurtosis imaging restricted diffusion short-time imaging
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 25
End Page 32
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236995
Web of Science KeyUT 000762812700004
JaLCDOI 10.18926/AMO/63203
FullText URL 76_1_7.pdf
Author Takami, Masao| Yamamoto, Koichiro| Hanayama, Yoshihisa| Nakano, Yasuhiro| Hasegawa, Kou| Obika, Mikako| Hagiya, Hideharu| Furukawa, Masanori| Otsuka, Fumio|
Abstract Subclinical hypothyroidism (SCH) is diagnosed when serum thyrotropin (TSH) is elevated despite a normal thyroxine level and is known to increase the risk of metabolic disorders. This study was conducted to identify potential laboratory markers suspicious for latent SCH. We retrospectively reviewed 958 outpatients in whom thyroid functions had been examined. Eighty-five (9.1%) of the 939 analyzed subjects had SCH (73% females). In the SCH group, median serum TSH and FT4 levels were 5.04 μU/ml and 1.19 ng/dl, respectively, and auto-thyroid antibodies were detected in 53.8% of patients. SCH group patients were significantly older than patients in the euthyroid group, while there was no intergroup difference in BMI. However, 56.5% of the SCH patients were asymptomatic. In the SCH group, serum aspartate aminotransferase and low-density lipoprotein cholesterol (LDL-C) levels were significantly higher, and the estimated glomerular filtration rate (eGFR) was significantly lower than in the euthyroid group. Among patients less than 65 years of age, SCH patients tended to have lower eGFR and higher LDL-C than euthyroid patients. Age-dependent reductions of red blood cells and serum albumin were more prominent in the SCH than the euthyroid group. Biochemical changes with aging are useful as potential clues for suspecting latent SCH.
Keywords aging renal function cholesterol subclinical hypothyroidism thyroid function
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 7
End Page 15
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236993
Web of Science KeyUT 000762812700002
JaLCDOI 10.18926/AMO/63202
FullText URL 76_1_1.pdf
Author Takao, Tomoka| Yamada, Daisuke| Takarada, Takeshi|
Abstract Optogenetics, a technology to manipulate biological phenomena thorough light, has attracted much attention in neuroscience. Recently, the Magnet System, a photo-inducible protein dimerization system which can control the intracellular behavior of various biomolecules with high accuracy using light was developed. Furthermore, photoactivation systems for controlling biological phenomena are being developed by combining this technique with genome-editing technology (CRISPR/Cas9 System) or DNA recombination technology (Cre-loxP system). Herein, we review the history of optogenetics and the latest Magnet System technology and introduce our recently developed photoactivatable Cre knock-in mice with temporal-, spatial-, and cell-specific accuracy.
Keywords optogenetics Cre recombinase
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 5
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236992
Web of Science KeyUT 000762812700001
FullText URL fulltext.pdf
Author Higo, Hisao| Ohashi, Kadoaki| Tomida, Shuta| Okawa, Sachi| Yamamoto, Hiromasa| Sugimoto, Seiichiro| Senoo, Satoru| Makimoto, Go| Ninomiya, Kiichiro| Nakasuka, Takamasa| Nishii, Kazuya| Taniguchi, Akihiko| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Miyahara, Nobuaki| Maeda, Yoshinobu| Toyooka, Shinichi| Kiura, Katsuyuki|
Keywords Idiopathic pulmonary fibrosis RNA sequencing Molecular therapeutic target Personalized therapy
Published Date 2022-02-07
Publication Title Respiratory Research
Volume volume23
Issue issue1
Publisher BMC
Start Page 20
ISSN 1465-993X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35130915
DOI 10.1186/s12931-022-01940-y
Web of Science KeyUT 000752386100002
Related Url isVersionOf https://doi.org/10.1186/s12931-022-01940-y
FullText URL fulltext20220216-3.pdf Figure20220216-3.pdf Supplementary Figure20220216-3.pdf
Author Nishimura, Yoshito| Hagiya, Hideharu| Keitoku, Koichi| Koyama, Toshihiro| Otsuka, Fumio|
Note © 2021 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ajic.2021.08.033] .|
Published Date 2022-01-28
Publication Title American Journal of Infection Control
Volume volume50
Issue issue2
Publisher Elsevier BV
Start Page 141
End Page 147
ISSN 0196-6553
NCID AA10617749
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Association for Professionals in Infection Control and Epidemiology, Inc.
File Version author
PubMed ID 34718066
DOI 10.1016/j.ajic.2021.08.033
Web of Science KeyUT 000749317500004
Related Url isVersionOf https://doi.org/10.1016/j.ajic.2021.08.033
FullText URL fulltext20220208-1.pdf
Author Onishi, Yasuhiro| Mise, Koki| Kawakita, Chieko| Uchida, Haruhito A.| Sugiyama, Hitoshi| Sugawara, Ryosuke| Yamaguchi, Satoshi| Yoshida, Michihiro| Mitsuhashi, Toshiharu| Yamada, Masao| Hirabayashi, Jun| Wada, Jun|
Keywords Glomerulonephritis IgA nephropathy Diagnostic biomarkers Lectins Glycomics
Note This is an Accepted Manuscript published by S. Karger AG.|
Published Date 2021-12-29
Publication Title American Journal of Nephrology
Volume volume53
Issue issue1
Publisher S. Karger AG
Start Page 10
End Page 20
ISSN 0250-8095
NCID AA10424676
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 S. Karger AG, Basel
File Version author
PubMed ID 34965524
DOI 10.1159/000520998
Web of Science KeyUT 000747743400001
Related Url isVersionOf https://doi.org/10.1159/000520998
Title Alternative Four types of duodenal white lesions (follicular lymphoma, lymphoid hyperplasia, lymphangiectasia, and lymphangioma) : A case report
FullText URL 133_175.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Okada, Hiroyuki|
Abstract  A 70-year-old Japanese man underwent esophagogastroduodenoscopy that revealed multiple whitish duodenal granules. The histopathological analysis of the biopsied specimen led to the diagnosis of duodenal-type follicular lymphoma. The lesion showed spontaneous improvement ; however, 14 months later a few small whitish granules were observed by esophagogastroduodenoscopy. Observation under magnification revealed slightly elevated opaque white spots and whitish granular protrusions of roughly the same size that were uniformly distributed in the duodenal bulb. The duodenal bulb lesions were histopathologically diagnosed as lymphoid hyperplasia. The patient also exhibited lymphangiectasia (which presented as scattered white spots) and lymphangioma (which presented as a soft submucosal tumor with white spots on the surface) in the second portion of the duodenum. This patient presented with four white lesions in the duodenum : duodenal-type follicular lymphoma, lymphoid hyperplasia, lymphangiectasia, and lymphangioma. Careful endoscopic evaluation enabled a prompt diagnosis in this case.
Keywords 十二指腸濾胞性リンパ腫(duodenal-type follicular lymphoma) リンパ濾胞過形成(lymphoid hyperplasia) リンパ管腫(lymphangioma) リンパ管拡張(lymphangiectasia)
Publication Title Journal of Okayama Medical Association
Published Date 2021-12-01
Volume volume133
Issue issue3
Start Page 175
End Page 180
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.133.175
language Japanese
Copyright Holders Copyright (c) 2021 岡山医学会
File Version publisher
DOI 10.4044/joma.133.175
FullText URL fulltext.pdf
Author Takemoto, Genta| Matsushita, Masaki| Okamoto, Takaaki| Ito, Toshinari| Matsuura, Yuki| Takashima, Chieko| Chen-Yoshikawa, Toyofumi Fengshi| Ebi, Hiromichi| Imagama, Shiro| Kitoh, Hiroshi| Ohno, Kinji| Hosono, Yasuyuki|
Keywords FGFR3 achondroplasia meclozine zebrafish bone
Published Date 2022-01-18
Publication Title Frontiers In Cell And Developmental Biology
Volume volume9
Publisher Frontiers Media SA
Start Page 694018
ISSN 2296-634X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Takemoto, Matsushita, Okamoto, Ito, Matsuura, Takashima, Chen-Yoshikawa, Ebi, Imagama, Kitoh, Ohno and Hosono.
File Version publisher
PubMed ID 35118060
DOI 10.3389/fcell.2021.694018
Web of Science KeyUT 000749267500001
Related Url isVersionOf https://doi.org/10.3389/fcell.2021.694018
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Takahashi, Takahide| Watanabe, Natsuki| Tanaka, Takehiro| Inokuchi, Toshihiro| Hiraoka, Sakiko| Otsuka, Fumio| Okada, Hiroyuki|
Keywords central memory T cell flow cytometry natural killer T cells peripheral blood mononuclear cell ulcerative colitis
Published Date 2022-01-12
Publication Title International Journal of Immunopathology and Pharmacology
Volume volume36
Publisher Sage Publications Inc.
Start Page 1
End Page 12
ISSN 0394-6320
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 35021918
DOI 10.1177/20587384211051982
Web of Science KeyUT 000747491200001
Related Url isVersionOf https://doi.org/10.1177/20587384211051982
FullText URL fulltext.pdf
Author Hassan, Ghmkin| Ohara, Toshiaki| Afify, Said M.| Kumon, Kazuki| Zahra, Maram H.| Fu, Xiaoying| Al Kadi, Mohamad| Seno, Akimasa| Salomon, David S.| Seno, Masaharu|
Keywords Cancer stem cells iPSCs Conversion Plasticity Tumorigenesis Pancreatic cancer microenvironments
Published Date 2022-01-21
Publication Title Journal Of Experimental & Clinical Cancer Research
Volume volume41
Issue issue1
Publisher BMC
Start Page 29
ISSN 1756-9966
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021.
File Version publisher
PubMed ID 35063003
DOI 10.1186/s13046-021-02167-3
Web of Science KeyUT 000745504400002
Related Url isVersionOf https://doi.org/10.1186/s13046-021-02167-3
FullText URL fulltext.pdf
Author Lin, Wenfeng| Chen, Wenwei| Zhong, Jisheng| Ueki, Hideo| Xu, Abai| Watanabe, Masami| Araki, Motoo| Liu, Chunxiao| Nasu, Yasutomo| Huang, Peng|
Keywords MICALL2 biomarker inflammation T cell exhaustion kidney renal clear cell carcinoma
Published Date 2022-01-16
Publication Title Journal Of Cancer
Volume volume13
Issue issue3
Publisher Ivyspring International Publisher
Start Page 1214
End Page 1228
ISSN 1837-9664
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The author(s).
File Version publisher
DOI 10.7150/jca.66922
Web of Science KeyUT 000746177200025
Related Url isVersionOf https://doi.org/10.7150/jca.66922
FullText URL fulltext.pdf
Author Hiranaka, Takaaki| Miyazawa, Shinichi| Furumatsu, Takayuki| Kodama, Yuya| Kamatsuki, Yusuke| Masuda, Shin| Okazaki, Yuki| Kintaka, Keisuke| Ozaki, Toshifumi|
Keywords Total knee arthroplasty Extension gap Flexion gap Predictor Navigation system
Published Date 2022-01-22
Publication Title BMC Musculoskeletal Disorders
Volume volume23
Issue issue1
Publisher BMC
Start Page 78
ISSN 1471-2474
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35065647
DOI 10.1186/s12891-022-05035-z
Web of Science KeyUT 000745608100002
Related Url isVersionOf https://doi.org/10.1186/s12891-022-05035-z
FullText URL fulltext.pdf
Author Nakayama, Rie| Takaya, Yoichi| Nakamura, Kazufumi| Takemoto, Rika| Toh, Norihisa| Ito, Hiroshi|
Keywords Congestion Heart failure Prognosis Shear wave elasticity
Published Date 2022-01-17
Publication Title ESC Heart Failure
Volume volume2022
Publisher Wiley Periodicals, Inc
ISSN 2055-5822
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 35038790
DOI 10.1002/ehf2.13809
Web of Science KeyUT 000743285100001
Related Url isVersionOf https://doi.org/10.1002/ehf2.13809
FullText URL fulltext.pdf
Author Oo, May Wathone| Kawai, Hotaka| Takabatake, Kiyofumi| Shan, Qiusheng| Eain, Htoo Shwe| Sukegawa, Shintaro| Nakano, Keisuke| Nagatsuka, Hitoshi|
Keywords oral squamous cell carcinoma invasion patient-derived stromal cell xenograft (PDSX) bone marrow-derived cells (BMDCs) MMP2 stromal factor IL-6 stromal factor IL1B
Published Date 2021-12-28
Publication Title Cancers
Volume volume14
Issue issue1
Publisher MDPI
Start Page 137
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 35008304
DOI 10.3390/cancers14010137
Web of Science KeyUT 000741719200001
Related Url isVersionOf https://doi.org/10.3390/cancers14010137
FullText URL fulltext.pdf
Author Tsuge, Mitsuru| Ikeda, Masanori| Kondo, Yoichi| Tsukahara, Hirokazu|
Keywords Bronchial asthma omalizumab bronchial wall thickness child computed tomography airway
Published Date 2022-01-07
Publication Title Journal Of International Medical Research
Volume volume50
Issue issue1
Publisher Sage Publications Ltd
Start Page 03000605211070492
ISSN 0300-0605
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 34994237
DOI 10.1177/03000605211070492
Web of Science KeyUT 000740552200001
Related Url isVersionOf https://doi.org/10.1177/03000605211070492
FullText URL fulltext.pdf
Author Tanaka, Yukie| Aung, Kyaw Thu| Ono, Mitsuaki| Mikai, Akihiro| Dang, Anh Tuan| Hara, Emilio Satoshi| Tosa, Ikue| Ishibashi, Kei| Ono-Kimura, Aya| Nawachi, Kumiko| Kuboki, Takuo| Oohashi, Toshitaka|
Keywords medication-related osteonecrosis of the jaw BMP-2 beta-tricalcium phosphate bone formation bone necrosis
Published Date 2021-11-26
Publication Title International Journal Of Molecular Sciences
Volume volume22
Issue issue23
Publisher MDPI
Start Page 12823
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34884630
DOI 10.3390/ijms222312823
Web of Science KeyUT 000735802700001
Related Url isVersionOf https://doi.org/10.3390/ijms222312823
FullText URL fulltext.pdf
Author Tachibana, Kota| Tang, Nina| Urakami, Hitoshi| Kajita, Ai| Kobashi, Mina| Nomura, Hayato| Sasakura, Minori| Sugihara, Satoru| Jiang, Fan| Tomonobu, Nahoko| Sakaguchi, Masakiyo| Ouchida, Mamoru| Morizane, Shin|
Keywords psoriasis vulgaris interleukin (IL) 23 IL-39 p19 Epstein-Barr virus-induced (EBI) 3 tildrakizumab
Published Date 2021-11-23
Publication Title International Journal Of Molecular Sciences
Volume volume22
Issue issue23
Publisher MDPI
Start Page 12659
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34884474
DOI 10.3390/ijms222312659
Web of Science KeyUT 000735457700001
Related Url isVersionOf https://doi.org/10.3390/ijms222312659
FullText URL fulltext.pdf
Author Uraguchi, Kensuke| Maeda, Yukihide| Takahara, Junko| Omichi, Ryotaro| Fujimoto, Shohei| Kariya, Shin| Nishizaki, Kazunori| Ando, Mizuo|
Published Date 2021-10-22
Publication Title PLOS ONE
Volume volume16
Issue issue10
Publisher Public Library Science
Start Page e0258977
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Uraguchi et al.
File Version publisher
PubMed ID 34679122
DOI 10.1371/journal.pone.0258977
Web of Science KeyUT 000733392900043
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0258977
FullText URL fulltext.pdf
Author Terasawa, Hiroyuki| Kinugasa, Hideaki| Nouso, Kazuhiro| Yamamoto, Shumpei| Hirai, Mami| Tanaka, Takehiro| Takaki, Akinobu| Okada, Hiroyuki|
Keywords Liquid biopsy Circulating tumor DNA Xenograft Esophageal squamous cell carcinoma Dynamics of circulating tumor DNA
Published Date 2021-11-07
Publication Title World Journal Of Gastroenterology
Volume volume27
Issue issue41
Publisher Baishideng Publishing Group Inc
Start Page 7134
End Page 7143
ISSN 1007-9327
NCID AA12048247
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021.
File Version publisher
PubMed ID 34887633
DOI 10.3748/wjg.v27.i41.7134
Web of Science KeyUT 000728118700010
Related Url isVersionOf https://doi.org/10.3748/wjg.v27.i41.7134
FullText URL fulltext20211210-3.pdf
Author Liu, Shihui| Miyaji, Mary| Hosoya, Osamu| Matsuo, Toshihiko|
Keywords apoptosis drug retina photoreceptors retinitis pigmentosa extracellular exosome extracellular matrix organization PI3K–Akt signaling pathway SERPINF1 pigment epithelium-derived factor (PEDF)
Published Date 2021-12-10
Publication Title International Journal of Molecular Sciences
Volume volume22
Issue issue24
Publisher MDPI
Start Page 13276
ISSN 1422-0067
NCID AA12038549
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
DOI 10.3390/ijms222413276
Related Url isVersionOf https://doi.org/10.3390/ijms222413276