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JaLCDOI 10.18926/AMO/58272
FullText URL 74_2_137.pdf
Author Isozaki, Hiroshi| Yamamoto, Yasuhisa| Sakai, Kunihiko| Sho, Tatuo| Ishihara, Kiyohiro| Murakami, Shigeki| Matsumoto, Sasau| Takama, Takehiro|
Abstract Mucinous carcinoma (MC) of the breast is a rare and special type of malignancy, with a substantial amount of extracellular mucin. We compared the clinicopathological features and the long-term survival of MC patients with those of invasive ductal carcinoma-no special type (IDC-NST) patients, and we examined prognostic factors of MC. A total of 116 patients with mucinous carcinoma and 3,258 patients with IDC-NST who underwent surgery at our hospital (1977-2008) were enrolled. The 10-year overall survival rate and breast cancer-specific survival rate (BSS) of the MC patients (88.3%, 93.7%) were both significantly higher than those of IDC-NST patients (81.6%, 85.0%) (p=0.015, p=0.005, respectively). A Cox regression analysis demonstrated that MC tended to be an independent prognostic factor (hazard ratio 0.44, p=0.098). The BSS of the MC patients with positive lymph node (LN) metastasis was significantly poorer than that of the patients without it, by univariate analysis (p=0.002). The tumor size in the MC patients with positive LN metastasis (mean 3.2 cm) was significantly larger than that in the patients without it (mean 1.9 cm) (p=0.0004). Although a Cox regression analysis revealed no independent factor, MC patients with positive LN metastasis should be treated for advanced invasive ductal breast cancer.
Keywords breast cancer mucinous carcinoma clinicopathological features long-term prognosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-04
Volume volume74
Issue issue2
Publisher Okayama University Medical School
Start Page 137
End Page 143
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32341588
Web of Science KeyUT 000528278500007
NAID 120006839451
JaLCDOI 10.18926/AMO/58271
FullText URL 74_2_129.pdf
Author Fukuma, Shogo| Shinya, Takayoshi| Soh, Junichi| Fukuhara, Ryuichiro| Ogawa, Nanako| Higaki, Fumiyo| Tanaka, Takehiro| Ichihara, Eiki| Hiraki, Takao| Toyooka, Shinichi| Kanazawa, Susumu|
Abstract The aim of this study was to explore enhancement patterns of different types of primary lung cancers on 2-phase dynamic computed tomography (CT). This study included 217 primary lung cancer patients (141 adenocarcinomas [ADs], 48 squamous cell carcinomas [SCCs], 20 small cell lung carcinomas [SCLCs], and 8 others) who were examined using a 2-phase dynamic scan. Regions of interest were identified and mean enhancement values were calculated. After excluding the 20 SCLCs because these lesions had different clinical stages from the other cancer types, the mean attenuation values and subtractions between phases were compared between types of non-small cell lung carcinomas (NSCLCs) using the Kruskal–Wallis test. Late phase attenuation and attenuation of the late minus unenhanced phase (LMU) of SCCs were significantly higher than those of ADs (p<0.05). To differentiate SCC and AD in the late phase, a threshold of 80.21 Hounsfield units (HU) gave 52.9% accuracy. In LMU, a threshold of 52.16 HU gave 59.3% accuracy. Dynamic lung CT has the potential to aid in differentiating among NSCLC types.
Keywords differentiation dynamic computed tomography primary lung cancer enhancement pattern
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-04
Volume volume74
Issue issue2
Publisher Okayama University Medical School
Start Page 129
End Page 135
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32341587
Web of Science KeyUT 000528278500006
NAID 120006839450
JaLCDOI 10.18926/AMO/58270
FullText URL 74_2_123.pdf
Author Fukuhara, Ryuichiro| Shinya, Takayoshi| Fukuma, Shogo| Ogawa, Nanako| Masaoka, Yoshihisa| Tanaka, Takehiro| Marunaka, Hidenori| Arioka, Tadashi| Hiraki, Takao| Kaji, Mitsumasa| Kanazawa, Susumu|
Abstract The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly.
Keywords 18F-fluorodeoxyglucose positron emission tomography/computed tomography extranodular spread metastasis oral squamous cell carcinoma
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-04
Volume volume74
Issue issue2
Publisher Okayama University Medical School
Start Page 123
End Page 128
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32341586
Web of Science KeyUT 000528278500005
NAID 120006839449
JaLCDOI 10.18926/AMO/58269
FullText URL 74_2_115.pdf
Author Kotani, Sayoko| Kamada, Yasuhiko| Shimizu, Keiko| Sakamoto, Ai| Nakatsuka, Mikiya| Hiramatsu, Yuji| Masuyama, Hisashi|
Abstract Thrombosis in decidual vessels is one of the mechanisms of pregnancy loss. However, few studies have assessed the relation between platelet activation, which is known to cause of thrombosis, and recurrent pregnancy loss (RPL). We investigated platelet activation in women with RPL compared to controls by measuring plasma levels of platelet factor 4 (PF4) and β-thromboglobulin (βTG), and assessed correlations between PF4/βTG and coagulative risk factors associated with RPL. The study group included 135 women who had experienced two or more consecutive pregnancy losses. The control group included 28 age-matched healthy women who had never experienced pregnancy loss. PF4 and βTG plasma levels were significantly higher in the women with RPL than controls (PF4: 14.0 [8.0-20.0] vs. 9.0 [6.0-12.0] ng/ml, p=0.043; βTG: 42.0 [24.3-59.8] vs. 31.5 [26.6-36.4] ng/ml, p=0.002). There was a significant association between βTG and anti-phosphatidylethanolamine antibody immunoglobulin M (aPE IgM) (p=0.048). Among the women with RPL, 18 of those who were positive for PF4 (45%) and 18 of those who were positive for βTG (37%) were negative for all known coagulative risk factors associated with RPL. Measurements of PF4 and βTG may be important because they help identify women who are at risk of RPL.
Keywords recurrent pregnancy loss platelet factor 4 β-thromboglobulin platelet activation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-04
Volume volume74
Issue issue2
Publisher Okayama University Medical School
Start Page 115
End Page 122
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32341585
Web of Science KeyUT 000528278500004
NAID 120006839448
JaLCDOI 10.18926/AMO/58268
FullText URL 74_2_109.pdf
Author Ogawa, Chikako| Nakamura, Keiichiro| Matsuoka, Hirofumi| Matsubara, Yuko| Haraga, Junko| Masuyama, Hisashi|
Abstract This study aimed to determine whether the risk conferred by gynecologic cancer (GC) as second primary cancer (SPC) differs from that associated with GC as first primary cancer (FPC). We investigated the correlations between FPC/SPC and the characteristics and prognoses of 1,645 GC patients (701 with cervical cancer [CC], 641 with endometrial cancer [EM], and 303 with ovarian cancer [OV]). The χ2 test and the Kaplan–Meier method were used to determine whether FPC/SPC and the characteristics and prognoses of GC patients. Of the SPC patients, 26 (3.7%) had CC, 53 (8.3%) had EM, and 31 (10.2%) had OV. The most common previous cancer type in SPC of GC patients was breast cancer, which was observed in 13 patients (50.0%) with CC, 23 (43.4%) with EM, and 16 (51.6%) with OV. In all patients with CC, EM, and OV as SPC, the stage was significantly associated with recurrence. There were no significant differences in the morbidity or mortality of CC, EM, or OV patients between those with FPC and those with SPC. The risk of SPC development in GC patients varied, ranging from 3.5% (CC) to 10.3% (OV) of patients.
Keywords second primary cancer gynecologic cancer prognosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-04
Volume volume74
Issue issue2
Publisher Okayama University Medical School
Start Page 109
End Page 114
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32341584
Web of Science KeyUT 000528278500003
NAID 120006839447
JaLCDOI 10.18926/AMO/58267
FullText URL 74_2_103.pdf
Author Kawada, Yasumasa| Kubo, Toru| Baba, Yuichi| Hirota, Takayoshi| Tanioka, Katsutoshi| Yamasaki, Naohito| Kitaoka, Hiroaki|
Abstract This study examined whether switching from amlodipine and atorvastatin treatment using two pills to an equal dose of single-pill therapy is useful in Japanese outpatients. We retrospectively reviewed data obtained from 94 outpatients for whom treatment with two pills, namely amlodipine and atorvastatin, was switched to an equal dose of single-pill therapy in 11 hospitals. The criterion for enrollment in this study was that patients had switched their medication without changing other anti-hypertensive or anti-cholesterol drugs. Neither systolic nor diastolic blood pressure changed significantly after switching to an equal dose of single-pill therapy, whereas low-density lipoprotein (LDL) cholesterol levels significantly decreased after the medication was switched from 94±24 mg/dl to 89±17 mg/dl (p=0.015). A switch from medication with two separate pills of amlodipine and atorvastatin to an equal dose of single-pill therapy resulted in an overall decrease in LDL cholesterol. The results indicated that the switch to single-pill therapy might be a useful treatment.
Keywords hypertension dyslipidemia single-pill therapy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-04
Volume volume74
Issue issue2
Publisher Okayama University Medical School
Start Page 103
End Page 108
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32341583
Web of Science KeyUT 000528278500002
NAID 120006839446
JaLCDOI 10.18926/AMO/58266
FullText URL 74_2_95.pdf
Author Kuba, Sayaka| Yamanouchi, Kosho| Morita, Michi| Sakimura, Chika| Inamasu, Eiko| Hatachi, Toshiko| Otsubo, Ryota| Matsumoto, Megumi| Yano, Hiroshi| Miyamoto, Junya| Sato, Shuntaro| Nakagawa, Hiroo| Kanetaka, Kengo| Takatsuki, Mitsuhisa| Nagayasu, Takeshi| Eguchi, Susumu|
Abstract We assessed the usefulness of ChemoCalc, a software package for calculating drug costs, in helping patients understand these costs. We randomly assigned, in a 1 : 1 ratio, 20 women who had undergone surgery for early breast cancer to a group that discussed adjuvant treatment with their physicians using the ChemoCalc software (ChemoCalc group) or a group that discussed adjuvant treatment without ChemoCalc (Usual Explanation group). The participants completed a five-grade evaluation questionnaire after these discussions. The primary endpoint was the intergroup comparison of the questionnaire scores regarding participants’ understanding of their treatment-associated drug costs. Median age was not significantly different between the ChemoCalc group and Usual Explanation group (57 vs. 50, respectively; p=0.27). Patients in the ChemoCalc group had a significantly higher perceived level of understanding of the drug cost than those in the Usual Explanation group (5 [4-5] vs. 2.5 [1-5], respectively; p=0.002). Scores related to the patients’ perception that understanding drug costs is an important part of breast cancer treatment were also higher in the ChemoCalc group than the Usual Explanation group (5 [2-5] vs. 3 [1-5], respectively; p=0.049). ChemoCalc was found to be useful for understanding drug costs.
Keywords breast cancer drug costs ChemoCalc
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-04
Volume volume74
Issue issue2
Publisher Okayama University Medical School
Start Page 95
End Page 101
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32341582
Web of Science KeyUT 000528278500001
NAID 120006839445
FullText URL fulltext.pdf
Author Uno, Soichiro| Okada, Masahiro| Taketa, Hiroaki| Torii, Yasuhiro| Matsumoto, Takuya|
Keywords Highly translucent partially stabilized zirconia Monoclinic phase Biaxial flexural strength Thermal treatment
Published Date 2020-03-27
Publication Title Dental Materials Journal
Volume volume39
Issue issue2
Publisher Japanese Society for Dental Materials and Devices
Start Page 295
End Page 301
ISSN 0287-4547
NCID AA10443149
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Japanese Society for Dental Materials and Devices
File Version publisher
PubMed ID 31827055
DOI 10.4012/dmj.2018-415
Related Url isVersionOf https://doi.org/10.4012/dmj.2018-415
FullText URL fulltext.pdf
Author Ogura, Soichiro| Nakamura, Kazufumi| Morita, Hiroshi| Toh, Norihisa| Nakagawa, Koji| Yoshida, Masashi| Watanabe, Atsuyuki| Nishii, Nobuhiro| Miyoshi, Toru| Ito, Hiroshi|
Keywords Electrocardiography Fragmented QRS Hospitalization Hypertrophic cardiomyopathy Ventricular arrhythmia.
Published Date 2020-02-25
Publication Title Circulation Journal
Volume volume84
Issue issue3
Publisher The Japanese Circulation Society
Start Page 487
ISSN 1346-9843
NCID AA11591968
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 THE JAPANESE CIRCULATION SOCIETY
File Version publisher
PubMed ID 32037379
DOI 10.1253/circj.CJ-19-0968
Web of Science KeyUT 000516606400021
Related Url isVersionOf https://doi.org/10.1253/circj.CJ-19-0968
FullText URL fulltext.pdf
Author Mino, Yasushi| Shinto, Hiroyuki|
Published Date 2020-03-13
Publication Title Physical Review E
Volume volume101
Issue issue3
Publisher American Physical Society
Start Page 033304
ISSN 2470-0045
NCID AA11558033
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
DOI 10.1103/PhysRevE.101.033304
Web of Science KeyUT 000519704000010
Related Url isVersionOf https://doi.org/10.1103/PhysRevE.101.033304
FullText URL fulltext.pdf
Author Mino, Yasushi| Shinto, Hiroyuki| Sakai, Shohei| Matsuyama, Hideto|
Published Date 2017-04-25
Publication Title Physical Review E
Volume volume95
Issue issue4
Publisher American Physical Society
Start Page 043309
ISSN 2470-0045
NCID AA11558033
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders ©2017 American Physical Society
File Version publisher
PubMed ID 28505823
DOI 10.1103/PhysRevE.95.043309
Web of Science KeyUT 000400238500012
Related Url isVersionOf https://doi.org/10.1103/PhysRevE.95.043309
FullText URL fulltext.pdf
Author Hirano, Yutaka| Sugimoto, Seiichiro| Yamamoto, Sumiharu| Okada, Masanori| Otani, Shinji| Ohara, Toshiaki| Yamane, Masaomi| Matsukawa, Akihiro| Oto, Takahiro| Toyooka, Shinichi|
Keywords Brain dead donor Donation after cardiac death Lung transplantation Organ preservation Rejection
Note This is a post-peer-review, pre-copyedit version of an article published in General Thoracic and Cardiovascular Surgery. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11748-019-01181-9.|
Published Date 2019-07-31
Publication Title General Thoracic and Cardiovascular Surgery
Volume volume68
Issue issue1
Publisher Springer
Start Page 57
End Page 62
ISSN 1863-6705
NCID AA12201344
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31367969
DOI 10.1007/s11748-019-01181-9
Web of Science KeyUT 000511499200009
Related Url isVersionOf https://doi.org/10.1007/s11748-019-01181-9
FullText URL fulltext.pdf figs.pdf tables.pdf
Author Itano, Junko| Higo, Hisao| Ohashi, Kadoaki| Makimoto, Go| Nishii, Kazuya| Hotta, Katsuyuki| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords osimertinib drug-induced ILD reversed halo sign organizing pneumonia pattern re-administration
Published Date 2020-03-15
Publication Title Internal Medicine
Volume volume59
Issue issue6
Publisher The Japanese Society of Internal Medicine
Start Page 823
End Page 828
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by The Japanese Society of Internal Medicine
File Version author
PubMed ID 31787696
DOI 10.2169/internalmedicine.3689-19
Web of Science KeyUT 000521137500011
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.3689-19
FullText URL fulltext.pdf
Author Kojima, Keiichi| Shibukawa, Atsushi| Sudo, Yuki|
Published Date 2019-12-09
Publication Title Biochemistry
Volume volume59
Issue issue3
Publisher American Chemical Society
Start Page 218
End Page 229
ISSN 0006-2960
NCID AA00564599
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31815443
DOI 10.1021/acs.biochem.9b00768
Web of Science KeyUT 000510530400003
Related Url isVersionOf https://doi.org/10.1021/acs.biochem.9b00768
FullText URL fulltext.pdf
Author Muraoka, Yuji| Yoshii, Fumiya| Fukuda, Takahiro| Manabe, Yuji| Yasuno, Mikiko| Takemoto, Yoshito| Terashima, Kensei| Wakita, Takanori| Yokoya, Takayoshi|
Keywords Strain effect Spinodal decomposition Titanium dioxide Vanadium dioxide Thin films Interdiffusion Nanostructure Pulsed laser deposition
Note © 2020 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.tsf.2020.137854] .|
Published Date 2020-03
Publication Title Thin Solid Films
Volume volume698
Publisher Elsevier
Start Page 137854
ISSN 0040-6090
NCID AA00863068
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1016/j.tsf.2020.137854
NAID 120007193924
Web of Science KeyUT 000521128800021
Related Url isVersionOf https://doi.org/10.1016/j.tsf.2020.137854
FullText URL fulltext.pdf
Author Araki, Yuya| Miyoshi, Natsumi| Morimoto, Kazuki| Kudoh, Takayuki| Mizoguchi, Haruki| Sakakura, Akira|
Note This document is the Accepted Manuscript version of a Published Work that appeared in final form inJournal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.9b02811. |
Published Date 2019-12-18
Publication Title Journal of Organic Chemistry
Volume volume85
Issue issue2
Publisher American Chemical Society
Start Page 798
End Page 805
ISSN 0022-3263
NCID AA00704100
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31850753
DOI 10.1021/acs.joc.9b02811
Web of Science KeyUT 000508468900045
Related Url isVersionOf https://doi.org/10.1021/acs.joc.9b02811
FullText URL jfl_072_content_e.pdf
Publication Title Journal of the Faculty of Letters Okayama University
Published Date 2019-12-20
Volume volume72
ISSN 0285-4864
language Japanese
File Version publisher
JaLCDOI 10.18926/okadai-bun-kiyou/58254
Title Alternative All Began with White : Paul Auster and His Thelxinoe
FullText URL jfl_072_039_052.pdf
Author Nakatani, Hitomi|
Publication Title Journal of the Faculty of Letters Okayama University
Published Date 2019-12-20
Volume volume72
Start Page 39
End Page 52
ISSN 0285-4864
language Japanese
File Version publisher
NAID 40022110137
JaLCDOI 10.18926/okadai-bun-kiyou/58253
Title Alternative A.Tatarinov ”Lexicon” Notes 9(Ц~Я)
FullText URL jfl_072_029_037.pdf
Author Eguchi, Yasuo|
Publication Title Journal of the Faculty of Letters Okayama University
Published Date 2019-12-20
Volume volume72
Start Page 29
End Page 37
ISSN 0285-4864
language Japanese
File Version publisher
NAID 40022110136
JaLCDOI 10.18926/okadai-bun-kiyou/58252
Title Alternative The Hiroshima Dialect across the Sea : Inheritance and Change in a Japanese Dialect in Overseas Japanese Immigrant Communities
FullText URL jfl_072_013_028.pdf
Author Nakato, Yasue|
Publication Title Journal of the Faculty of Letters Okayama University
Published Date 2019-12-20
Volume volume72
Start Page 13
End Page 28
ISSN 0285-4864
language Japanese
File Version publisher
NAID 40022110121