A Prompt Diagnosis of Ascites and Dramatic Effect of Alectinib for Advanced Lung Adenocarcinoma Harboring EML4-ALK Fusion

Baba, Takahiro; Inoue, Hirofumi; Matsuoka, Hiromi; Kyakuno, Mio; Yoshinaga, Yusuke; Takeguchi, Tetsuya; Fujiwara, Miho; Yamada, Kotaro; Nakamura, Eri; Morita, Ayako; Hara, Naofumi; Ninomiya, Kiichiro; Higo, Hisao; Fujii, Masanori; Ichihara, Eiki; Rai, Kammei; Ohashi, Kadoaki; Hotta, Katsuyuki; Tabata, Masahiro; Maeda, Yoshinobu; Togashi, Yosuke; Makimoto, Go

doi:10.2169/internalmedicine.5397-25

Permalink : http://escholarship.lib.okayama-u.ac.jp/69789

ID	69789
FullText URL	fulltext.pdf 1.46 MB
Author	Baba, Takahiro Department of Respiratory Medicine, Okayama University Hospital Inoue, Hirofumi Department of Medical Support, Okayama University Hospital Matsuoka, Hiromi Department of Medical Support, Okayama University Hospital Kyakuno, Mio Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine Yoshinaga, Yusuke Department of Respiratory Medicine, Okayama University Hospital Takeguchi, Tetsuya Department of Respiratory Medicine, Okayama University Hospital Fujiwara, Miho Department of Respiratory Medicine, Okayama University Hospital Yamada, Kotaro Department of Respiratory Medicine, Okayama University Hospital Nakamura, Eri Department of Respiratory Medicine, Okayama University Hospital Morita, Ayako Department of Respiratory Medicine, Okayama University Hospital Hara, Naofumi Department of Respiratory Medicine, Okayama University Hospital Ninomiya, Kiichiro Center for Comprehensive Genomic Medicine, Okayama University Hospital Kaken ID Higo, Hisao Department of Respiratory Medicine, Okayama University Hospital Fujii, Masanori Department of Geriatric Medicine, Okayama University Hospital Ichihara, Eiki Center for Clinical Oncology, Okayama University Hospital Kaken ID publons Rai, Kammei Center for Innovative Clinical Medicine, Okayama University Hospital Ohashi, Kadoaki Department of Respiratory Medicine, Okayama University Hospital ORCID Kaken ID researchmap Hotta, Katsuyuki Center for Innovative Clinical Medicine, Okayama University Hospital Kaken ID publons researchmap Tabata, Masahiro Center for Clinical Oncology, Okayama University Hospital Kaken ID researchmap Maeda, Yoshinobu Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Kaken ID researchmap Togashi, Yosuke Department of Respiratory Medicine, Okayama University Hospital ORCID Kaken ID researchmap Makimoto, Go Department of Respiratory Medicine, Okayama University Hospital
Abstract	A 75-year-old never-smoker woman presented with dyspnea and loss of appetite. A mass was identified in the left upper lobe of the lung, and the patient was referred to our hospital. Despite the diagnosis of lung adenocarcinoma via bronchoscopy, anaplastic lymphoma kinase (ALK) immunostaining was negative. Rapid weight gain and abdominal distension caused by ascites prompted fluid testing using the AmoyDx® Pan Lung Cancer PCR Panel. EML4-ALK fusion was confirmed, and alectinib therapy was initiated immediately. The tumor size had decreased significantly, and the patient was discharged on day 34. This case highlights the necessity of multiplex genetic testing even when ALK immunostaining is negative.
Keywords	lung adenocarcinoma EML4-ALK AmoyDxⓇ Pan Lung Cancer PCR Panel alectinib
Published Date	2025-12-01
Publication Title	Internal Medicine
Volume	volume64
Issue	issue23
Publisher	Japanese Society of Internal Medicine
Start Page	3413
End Page	3418
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	40399085
DOI	10.2169/internalmedicine.5397-25
Web of Science KeyUT	001494126400001
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.5397-25
License	https://creativecommons.org/licenses/by-nc-nd/4.0/