Studies on leukemia in the C3Hf strain of mice,2.

Spontaneous C3Hf lymphatic leukemia maintained in an ascites form was transplanted into newborn Wistar rats less than 24 hours old. Single subcutaneous or intraperitoneal inoculation of the neoplastic cells resulted in progressive tumor growth fatal to the heterologous hosts. Limited serial passage through newborn rats was performed. The intraperitoneally heterografted leukemia grew as massive lymphosarcoma predominantly in the adipose and connective tissue compartments with invasion of the neighboring organs but without leukemic manifestations. The characteristic behavior and histopathologic features of the transplanted disease are presented in comparison with the results of similar experiments reported in the literature.