On the Effect of Oxidizable Substance upon the Gaseous Metabolism of the Castrated Male or Female Animals.

1) The gaseous metabolism of guinea pigs (male and female) decreases to a certain extent after the removal of sexual glands, but it increases temporarily through the administration of the extract (of testis or ovary), up to the normal value as before the operation. 2) The testis extract has a little influence on increasing the gaseous metabolism of the ovariectomised guinea pigs and it is also temporary. 3) The oxidizable substances cause the gaseous metabolism of ovariectomised guinea pigs to increase markedly. 4) The gaseous metabolism of the castrated male is increased under the administration of the oxidizable substance of certain plant juices and the ratio of increase is proportional to the quantity of the oxidizable substance given, and the more, if the testis extract be added together. 5) The gaseous metabolism of the castrated animals fed with the basal diet free from vitamin C tends to diminish again. This diminished gaseous metabolism is only restored to the former level or more by the administration of vitamin C.