result 47495 件
| JaLCDOI | 10.18926/15147 |
|---|---|
| Title Alternative | 気管支喘息における複合温泉療法と気道炎症反応 |
| FullText URL | 065_001_008.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro| Ochi, Koji| Harada, Hideo| Tada, Shinya| Harada, Mine| |
| Abstract | Efficacy of complex spa therapy was studied in 55 patients with bronchial asthma. Complex spa therapy was effective in 47 (85.5%) of the 55 patients with bronchial asthma : marked efficacy was observed in 15 (27.3%), moderate in 32 (58.2%), slight in 6 (10.9%) and no efficacy in 2 patients (3.6%). Improvement of clinical symptoms and findings by complex spa therapy was more clearly observed in patients with an increased proportion of BAL lymphocytes, neutrophils and eosinophils. These findings suggest that complex spa therapy more affects cell infiltration in the airways than bronchoconstriction induced by chemical mediators. Improvement of ventilatory function represented by FEV1.0% value was higher in patients with a low proportion of BAL neutrophils, suggesting that patients with increased number of BAL neutrophils require longer complex spa therapy than those without BAL neutrophilia. |
| Keywords | complex spa therapy (複合温泉療法) airway inflammation (気道炎症反応) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1994-09 |
| Volume | volume65 |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307726 |
| Author | 岡山医学会| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Others |
| Author | 園尾 博司| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Others |
| Author | 道端 達也| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Article |
| Author | 窪田 政寛| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Article |
| Author | 臼井 隆| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Article |
| Author | Wake, Hidenori| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Hiramatsu, Yuji| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kawano, Seiji| Okada, Hiroyuki| Kawahara, Yoshiro| Inoue, Masafumi| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Inoue, Masafumi| Okada, Hiroyuki| Kawahara, Yoshiro| Kawano, Seiji| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Doi, Hiroyuki| Komatsu, Hirokazu| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Sendo, Toshiaki| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Ito, Hiroshi| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nomiya, Rie| Okano, Mitsuhiro| Fujiwara, Tazuko| Nishizaki, Kazunori| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kashiwakura, Yuji| |
|---|---|
| Published Date | 2009-08-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | 横田 美香| 岩崎 志保| |
|---|---|
| Published Date | 1997-12-20 |
| Publication Title | 岡山大学構内遺跡発掘調査報告 |
| Volume | volume13 |
| Content Type | Research Paper |
| Author | 岡山大学医学部附属病院三朝分院| |
|---|---|
| Published Date | 1995-09 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume66 |
| Content Type | Others |
| Author | Matsubara, Fumie| Inoue, Taeko| Mifune, Takashi| Tanizaki, Yoshiro| |
|---|---|
| Published Date | 1995-09 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume66 |
| Content Type | Data or Dataset |
| JaLCDOI | 10.18926/15129 |
|---|---|
| FullText URL | 066_085_091.pdf |
| Author | Chowdhury Riaz| Ochi, Koji| Harada, Hideo| Tanaka, Juntaro| Mizushima, Takaaki| Matsumoto, Shuji| Seno, Toshinobu| Ichimura, Mitsuko| Akiyama, Tsuneo| Yokota, Satoshi| |
| Abstract | Experimental model of pancreatitis is mandatory for elucidating the pathobiology of the disease and also to see the response of a novel treatment. In addition, the need for an animal model of chronic pancreatitis is further strengthened by the relative inaccessibility and paucity of the human pancreatitis tissue. Whereas various models of acute pancreatitis and also of exocrine pancreatic tumor have been described, chronic pancr-eatitis has not been consistently reproduced in experimental animals. Many researchers attempted to establish an experimental model of chronic pancreatitis either by partially obstructing the drainage of pancreatic secretion in dogs and cats or by feeding alcohol to dogs and rats with and without temporary occlusion of the biliopancreatic duct or by surgically inducing ischaemia in the pancreas of the dogs. But, none of these models is identical with human disease. A consistently reproducible model of human chronic pancr-eatitis probably does not exist. In this expanding era of molecular biology which promises us to enhance greatly our understanding of this disease, a right experimental model of chronic pancreatitis is still in progress. |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 85 |
| End Page | 91 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307190 |
| JaLCDOI | 10.18926/15128 |
|---|---|
| Title Alternative | Collagen degradation and in the pathogenesis of dieseases |
| FullText URL | 066_078_084.pdf |
| Author | Ochi, Koji| Harada, Hideo| Chowdhury Riaz| Yamashita, Haruhiro| Ichimura, Mitsuko| Tanaka, Juntaro| Seno, Toshinobu| Matsumoto, Shuji| Mizushima, Takaaki| Yokota, Satoshi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | 組織のコラーゲン沈着にはコラーゲン合成系と分解系の不均衡によって生ずる｡従来,主としてコラーゲン合成系が注目されていたが,最近の研究の進歩により,コラーゲン分解系が重要な役割を演ずることが明らかになってきた｡コラーゲンの分解系には細胞内と細胞外の二つの経路が存在する｡それぞれcollagenolytic cathepsinおよびmatrix metalloproteinases( MMP)がコラーゲン分解能を有する重要な酵素である｡その調節因子については細胞外の経路についての解明か進んでいる｡MMPの遺伝子の発現にはサイトカインや成長因子が関与し,IL-1やTNF-αは強力な誘導因子である｡一旦,遺伝子か発現すれば,MMPは合成され,細胞外に不活性型(latent form)で分泌される｡不活性型のMMPが活性化する過程にはplasminogen activator inhibitorやtissue inhibitors of metalloproteinases(TIMP)などの阻害因子が存在し,MMP活性を調節する｡TIMPの遺伝子の発現にもサイトカインや成長因子が関与する｡MMPがTIMPを上回るような病態では組織破壊が,逆にTIMPがMMPを上回るような病態では綿維化が生ずる｡コラーゲン分解能の障害が線維化の維持や不可逆性に関与することが推察される。 |
| Keywords | 線維化 (Fibrosis) コラーゲン (Collagen) TIMP (tissue inhibitor of metalloproteinase) MMP (matrix metalloproteinase) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 78 |
| End Page | 84 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307516 |
