result 465 件
| Title Alternative | Evaluation of a one-step nucleic acid amplification (OSNA) assay for sentinel lymph node metastases in early breast cancer |
|---|---|
| FullText URL | 126_25.pdf |
| Author | Mizoo, Taeko| Shien, Tadahiko| Ito, Maiko| Nogami, Tomohiro| Iwamoto, Takayuki| Motoki, Takayuki| Taira, Naruto| Matsuoka, Junji| Doihara, Hiroyoshi| |
| Abstract | Introduction: The one-step nucleic acid amplification (OSNA) assay is a new method to detect sentinel lymph node (SLN) metastases using cytokeratin 19 (CK19) mRNA in early breast cancer. Here we retrospectively analyzed the advantages and disadvantages of the OSNA assay. Methods: In a trial period, SLNs were divided into two sections, and we examined one side using the OSNA assay. The other side was examined by pathologists. After this period, we examined whole SLNs using only the OSNA assay. The patients with positive nodes by OSNA assay and/or pathology required axillary dissection. Results: We examined 27 primary breast cancer patients (36 SLNs) during the trial period. The overall concordance rate between the OSNA assay and pathology results was 91%. In the later period, 157 patients (217 SLNs) were examined. The CK19-positive rate obtained by the OSNA assay was 16.5% (macrometastases OSNA (++) : 7.2%, micrometastases OSNA (+) : 9.2%). The non-SLN positive rate among the CK19-positivecases was 23%. The OSNA assay's false negative was one case in which the expression of CK-19 on the primary tumor and lymph node was not detected. Conclusions: Our OSNA assay results were comparable to those obtained using a conventional pathological technique. Pathologists and laboratory technicians could save time and effort by using the OSNA assay when seeking the precise diagnosis during surgery. |
| Keywords | OSNA法（OSNA method） センチネルリンパ節（sentinel lymph node） micrometastases CK-19 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 25 |
| End Page | 30 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.25 |
| Title Alternative | A preoperative SUVmax greater than the ADCmin of the primary tumour : A predictor of disease recurrence and survival in patients with endometrial cancer |
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| FullText URL | 126_11.pdf |
| Author | Nakamura, Keiichiro| Joja, Ikuo| Fukushima, Chikako| Haruma, Tomoko| Hayashi, Chiaki| Kusumoto, Tomoyuki| Seki, Noriko| Hongo, Atsushi| Hiramatsu, Yuji| |
| Keywords | endometrial cancer SUVmax PET/CT predictor of poor prognosis |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 11 |
| End Page | 15 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.11 |
| JaLCDOI | 10.18926/AMO/52010 |
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| FullText URL | 67_6_369.pdf |
| Author | Yu, Shaonan| Wang, Xiaozhen| Liu, Guifeng| Zhu, Xuewei| Chen, Yan| |
| Abstract | Despite high sensitivity to chemotherapy, the prognosis for triple-negative breast cancer (TNBC) remains poor because of its high rate of metastasis and low sensitivity to endocrine therapy. CXCR4 expression has been reported in many subtypes of human breast cancers, but it remains unknown whether CXCR4 is expressed in TNBC and whether CXCR4 expression in TNBC could be a prognostic indicator. TNBCs tissues were formalin fixed, paraffin embedded and hematoxylin-eosin (H&E) stained. Immunohistochemical staining was utilized to determine the CXCR4 expression in those specimens. Statistical analyses were performed using SPSS16.0 software to reveal the correlation of CXCR4 expression in TNBC specimens and cancer recurrence and cancer-related death. Our results showed that there was a strong association between CXCR4 overexpression and both menopause and the histological cancer grade of TNBC patients (p values were separately 0.004 and 0.001). The 5-y disease-free survival (DFS) and the 5-y overall survival (OS) were 57.69% and 58.33% for the low-CXCR4 group versus 42.11% and 44.74% for the high-CXCR4 group, respectively (p＝0.031 and 0.048). CXCR4 overexpression plays an important role in triple-negative breast cancers, and may be a predictor of poor prognosis. |
| Keywords | CXCR4 immunohistochemical staining triple-negative breast cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 369 |
| End Page | 375 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356721 |
| Web of Science KeyUT | 000328915700005 |
| FullText URL | K0004854_abstract_review.pdf K0004854_fulltext.pdf |
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| Author | Sreeja C Sekhar| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4854号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | Japanese English |
| Author | Doihara, Hiroyoshi| |
|---|---|
| Published Date | 2013-12-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Ohuchi, Hideyo| |
|---|---|
| Published Date | 2013-12-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/51065 |
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| FullText URL | 67_4_213.pdf |
| Author | Kawahara, Michiko| Sato, Shuhei| Ida, Yukiko| Watanabe, Masao| Fujishima, Mamoru| Ishii, Hiroaki| Hori, Keisuke| Kanazawa, Susumu| |
| Abstract | A relatively large number of women in their 40s with high-density breasts, in which it can be difficult to detect lesions, are encountered in mammography cancer screenings in Japan. Here, we retrospectively investigated factors related to breast density. Two hundred women (40-49 years old) were examined at the screening center in our hospital. Multivariate analysis showed that factors such as small abdominal circumference, high HDL cholesterol, and no history of childbirth were related to high breast density in women in their 40s undergoing mammography. Other non-mammographic screening methods should be considered in women with abdominal circumferences ＜76cm, HDL-C >53mg/dl, and no history of childbirth, as there is a strong possibility of these women having high-density breasts that can make lesion detection difficult. |
| Keywords | high-density breasts abdominal circumference high-density lipoprotein cholesterol childbirth mammography |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-08 |
| Volume | volume67 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 213 |
| End Page | 217 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23970319 |
| Web of Science KeyUT | 000323470100002 |
| Author | Ueno, Tsuyoshi| Tsukuda, Kazunori| Toyooka, Shinichi| Ando, Midori| Takaoka, Munenori| Soh, Junichi| Asano, Hiroaki| Maki, Yuho| Muraoka, Takayuki| Tanaka, Norimitsu| Shien, Kazuhiko| Furukawa, Masashi| Yamatsuji, Tomoki| Kiura, Katsuyuki| Naomoto, Yoshio| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2012-04 |
| Publication Title | Lung Cancer |
| Volume | volume76 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Tanaka, Norimitsu| Toyooka, Shinichi| Soh, Junichi| Kubo, Takafumi| Yamamoto, Hiromasa| Maki, Yuho| Muraoka, Takayuki| Shien, Kazuhiko| Furukawa, Masashi| Ueno, Tsuyoshi| Asano, Hiroaki| Tsukuda, Kazunori| Aoe, Keisuke| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2012-04 |
| Publication Title | Lung Cancer |
| Volume | volume76 |
| Issue | issue1 |
| Content Type | Journal Article |
| FullText URL | K0004673.pdf K0004673_honbun.pdf |
|---|---|
| Author | Ishihara, Setsuko| |
| Published Date | 2013-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4673号 |
| Granted Date | 2013-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| Author | Shien, Kazuhiko| Toyooka, Shinichi| Ichimura, Kouichi| Soh, Junichi| Furukawa, Masashi| Maki, Yuho| Muraoka, Takayuki| Tanaka, Norimitsu| Ueno, Tsuyoshi| Asano, Hiroaki| Tsukuda, Kazunori| Yamane, Masaomi| Oto, Takahiro| Kiura, Katsuyuki| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2012-07 |
| Publication Title | Lung Cancer |
| Volume | volume77 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/50409 |
|---|---|
| FullText URL | 67_3_165.pdf |
| Author | Shien, Tadahiko| Kinoshita, Takayuki| Seki, Kunihiko| Yoshida, Miwa| Hojo, Takashi| Shimizu, Chikako| Taira, Naruto| Doihara, Hiroyoshi| Akashi-Tanaka, Sadako| Tsuda, Hitoshi| Fujiwara, Yasuhiro| |
| Abstract | While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the National Cancer Center Hospital (NCCH). We analyzed EGFR, HER2, and p53 expression and common clinicopathological features from the CNB and surgical specimens of these patients. These biological markers were compared between sensitive patients (pathological complete response;pCR) and insensitive patients (clinical no change;cNC and clinical progressinve disease;cPD). In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC. p53 (p＝0.045) and histological grade 3 (p＝0.011) were important and significant predictors of the response to NAC. The correspondence rates for histological type, histological grade 3, ER, PgR, HER2, p53, and EGFR in insensitive patients between CNB and surgical specimens were 70%, 73%, 67%, 70%, 80%, 93%, and 73%. The pathologic response was significantly associated with p53 expression and histological grade 3. The correspondence rate of p53 expression between CNB and surgical specimens was higher than that of other factors. We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC. |
| Keywords | breast cancer neoadjuvant chemotherapy predictors |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-06 |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 165 |
| End Page | 170 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23804139 |
| Web of Science KeyUT | Pretreatment Specimen Predicts |
| JaLCDOI | 10.18926/AMO/50407 |
|---|---|
| FullText URL | 67_3_145.pdf |
| Author | Ishihara, Setsuko| Taira, Naruto| Kawasaki, Kensuke| Ishibe, Youichi| Mizoo, Taeko| Nishiyama, Keiko| Iwamoto, Takayuki| Nogami, Tomohiro| Motoki, Takayuki| Shien, Tadahiko| Matsuoka, Junji| Doihara, Hiroyoshi| Komoike, Yoshifumi| Sato, Shuhei| Kanazawa, Susumu| |
| Abstract | A high mammographic breast density is considered to be a risk factor for breast cancer. However, only a small number of studies on the association between breast density and lifestyle have been performed. A cross-sectional study was performed using a survey with 29 questions on life history and lifestyle. The breast density on mammography was classified into 4 categories following the BI-RADS criteria. The subjects were 522 women with no medical history of breast cancer. The mean age was 53.3 years old. On multivariate analysis, only BMI was a significant factor determining breast density in premenopausal women (parameter estimate, －0.403;p value, 0.0005), and the density decreased as BMI rose. In postmenopausal women, BMI (parameter estimate, －0.196;p value, 0.0143) and number of deliveries (parameter estimate, －0.388;p value, 0.0186) were significant factors determining breast density;breast density decreased as BMI and number of deliveries increased. Only BMI and number of deliveries were identified as factors significantly influencing breast density. BMI was inversely correlated with breast density before and after menopause, whereas the influence of number of deliveries on breast density was significant only in postmenopausal women in their 50 and 60s. |
| Keywords | breast cancer mammographic breast density life style body mass index |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-06 |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 145 |
| End Page | 151 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23804137 |
| Web of Science KeyUT | 000320747900003 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/50646 |
| JaLCDOI | 10.18926/AMO/49669 |
|---|---|
| FullText URL | 67_2_105.pdf |
| Author | Alafate, Aierken| Shinya, Takayoshi| Okumura, Yoshihiro| Sato, Shuhei| Hiraki, Takao| Ishii, Hiroaki| Gobara, Hideo| Kato, Katsuya| Fujiwara, Toshiyoshi| Miyoshi, Shinichiro| Kaji, Mitsumasa| Kanazawa, Susumu| |
| Abstract | We retrospectively evaluated the accumulation of fluorodeoxy glucose (FDG) in pulmonary malignancies without local recurrence during 2-year follow-up on positron emission tomography (PET)/computed tomography (CT) after radiofrequency ablation (RFA). Thirty tumors in 25 patients were studied (10 non-small cell lung cancers;20 pulmonary metastatic tumors). PET/CT was performed before RFA, 3 months after RFA, and 6 months after RFA. We assessed the FDG accumulation with the maximum standardized uptake value (SUVmax) compared with the diameters of the lesions. The SUVmax had a decreasing tendency in the first 6 months and, at 6 months post-ablation, FDG accumulation was less affected by inflammatory changes than at 3 months post-RFA. The diameter of the ablated lesion exceeded that of the initial tumor at 3 months post-RFA and shrank to pre-ablation dimensions by 6 months post-RFA. SUVmax was more reliable than the size measurements by CT in the first 6 months after RFA, and PET/CT at 6 months post-RFA may be more appropriate for the assessment of FDG accumulation than that at 3 months post-RFA. |
| Keywords | fluorodeoxy glucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) radiofrequency ablation (RFA) non-small cell lung cancer (NSCLC) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-04 |
| Volume | volume67 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 105 |
| End Page | 112 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23603927 |
| Web of Science KeyUT | 000317801700005 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/50688 |
| Author | Yoshida, Ryosuke| Tazawa, Hiroshi| Hashimoto, Yuuri| Yano, Shuya| Onishi, Teppei| Sasaki, Tsuyoshi| Shirakawa, Yasuhiro| Kishimoto, Hiroyuki| Uno, Futoshi| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-11 |
| Publication Title | Cancer Immunology, Immunotherapy |
| Volume | volume61 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Inada, Ryo| Nagasaka, Takeshi| Takehara, Kiyoto| Sugihara, Masahiro| Mori, Yoshiko| Umeda, Yuzo| Kubota, Nobuhito| Morikawa, Tatsuya| Kondo, Yoshitaka| Uno, Futoshi| Sadamori, Yu| Yagi, Takahito| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/49253 |
|---|---|
| FullText URL | 67_1_19.pdf |
| Author | Furukawa, Masashi| Soh, Junichi| Yamamoto, Hiromasa| Ichimura, Kouichi| Shien, Kazuhiko| Maki, Yuho| Muraoka, Takayuki| Tanaka, Norimitsu| Ueno, Tsuyoshi| Asano, Hiroaki| Tsukuda, Kazunori| Toyooka, Shinichi| Miyoshi, Shinichiro| |
| Abstract | Nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α (NFKBIA), which is a tumor suppressor gene, was found to be silenced in lung adenocarcinomas. We examined NFKBIA expression, mutations in the EGFR and K-ras genes, and EML4-ALK fusion in 101 resected lung adenocarcinoma samples from never-smokers. NFKBIA expression was evaluated using immunohistochemistry. NFKBIA expression was negative in 16 of the 101 samples (15.8%). EGFR and K-ras mutations and EML4-ALK fusion were detected in 61 (60.5%), 1 (1.0%), and 2 (2.0%) of the 101 samples, respectively, in a completely mutually exclusive manner. Negative NFKBIA expression was observed significantly more frequently among the tumors with none of the three genetic alterations compared to those with such alterations (p＝0.009). In addition, negative NFKBIA expression was significantly more frequent among the EGFR-wild type samples compared to the EGFR-mutant samples (p＝0.013). In conclusion, NFKBIA expression was silenced in adenocarcinomas without EGFR/K-ras mutations or EML4-ALK fusion, suggesting that the silencing of NFKBIA may play an important role in the carcinogenesis of adenocarcinomas independent of EGFR/K-ras mutations or EML4-ALK fusion. |
| Keywords | never-smoker lung cancer adenocarcinoma nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α epidermal growth factor receptor |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-02 |
| Volume | volume67 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 19 |
| End Page | 24 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23439505 |
| Web of Science KeyUT | 000316829900003 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52534 |
| Author | Imada, Takako| Matsuoka, Junji| Motoki, Takayuki| Iwamoto, Takayuki| Oomori, Masako| Iha, Sigemichi| Hongo, Toshie| Henmi, Noriko| Makabe, Mikio| Nogami, Hiromi| |
|---|---|
| Published Date | 2012-12-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Nakabayashi, Hidekazu| Taketa, Kazuhisa| |
|---|---|
| Published Date | 2012-12-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Kubo, Takafumi| Toyooka, Shinichi| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2012-12-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue3 |
| Content Type | Journal Article |
