result 47501 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakata, Kentaro| Okazaki, Mikio| Sakaue, Tomohisa| Kinoshita, Rie| Komoda, Yuhei| Shimizu, Dai| Yamamoto, Haruchika| Tanaka, Shin| Suzawa, Ken| Shien, Kazuhiko| Miyoshi, Kentaroh| Yamamoto, Hiromasa| Ohara, Toshiaki| Sugimoto, Seiichiro| Yamane, Masaomi| Matsukawa, Akihiro| Sakaguchi, Masakiyo| Toyooka, Shinichi| |
| Keywords | ischemia reperfusion injury S100A8/A9 lung transplantation damage-associated molecule patterns |
| Published Date | 2022-11-10 |
| Publication Title | Bioengineering |
| Volume | volume9 |
| Issue | issue11 |
| Publisher | MDPI |
| Start Page | 673 |
| ISSN | 2306-5354 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36354584 |
| DOI | 10.3390/bioengineering9110673 |
| Web of Science KeyUT | 000880897200001 |
| Related Url | isVersionOf https://doi.org/10.3390/bioengineering9110673 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Maruo, Yukinori| Yoshihara, Kumiko| Irie, Masao| Nagaoka, Noriyuki| Matsumoto, Takuya| Minagi, Shogo| |
| Keywords | acrylate methacrylate CAD/CAM flexural strength shear bond strength |
| Published Date | 2022-10-28 |
| Publication Title | Materials |
| Volume | volume15 |
| Issue | issue21 |
| Publisher | MDPI |
| Start Page | 7564 |
| ISSN | 1996-1944 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36363156 |
| DOI | 10.3390/ma15217564 |
| Web of Science KeyUT | 000881219600001 |
| Related Url | isVersionOf https://doi.org/10.3390/ma15217564 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Oo, May Wathone| Kawai, Hotaka| Eain, Htoo Shwe| Soe, Yamin| Takabatake, Kiyofumi| Sanou, Sho| Shan, Qiusheng| Inada, Yasunori| Fujii, Masae| Fukuhara, Yoko| Wang, Ziyi| Sukegawa, Shintaro| Ono, Mitsuaki| Nakano, Keisuke| Nagatsuka, Hitoshi| |
| Keywords | oral squamous cell carcinoma tumor microenvironment tumor stroma tumor vascularization extracellular superoxide dismutase (SOD3) vascular endothelial cadherin (Ve-cadherin) |
| Published Date | 2022-10-28 |
| Publication Title | Biomedicines |
| Volume | volume10 |
| Issue | issue11 |
| Publisher | MDPI |
| Start Page | 2729 |
| ISSN | 2227-9059 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36359248 |
| DOI | 10.3390/biomedicines10112729 |
| Web of Science KeyUT | 000881045700001 |
| Related Url | isVersionOf https://doi.org/10.3390/biomedicines10112729 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Werner, Rudolf A.| Higuchi, Takahiro| Nose, Naoko| Toriumi, Fujio| Matsusaka, Yohji| Kuji, Ichiei| Kazuhiro, Koshino| |
| Published Date | 2022-11-05 |
| Publication Title | Scientific Reports |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 18787 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 36335166 |
| DOI | 10.1038/s41598-022-23325-3 |
| Web of Science KeyUT | 000879722100016 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-022-23325-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yokogi, Kyoka| Goto, Yuki| Otsuka, Mai| Ojima, Fumiya| Kobayashi, Tomoe| Tsuchiba, Yukina| Takeuchi, Yu| Namba, Masumi| Kohno, Mayumi| Tetsuka, Minami| Takeuchi, Sakae| Matsuyama, Makoto| Aizawa, Sayaka| |
| Published Date | 2022-10-27 |
| Publication Title | Scientific Reports |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 17472 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 36302800 |
| DOI | 10.1038/s41598-022-21764-6 |
| Web of Science KeyUT | 000876924900034 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-022-21764-6 |
| FullText URL | fulltext20221117-1.pdf |
|---|---|
| Author | Katayama, Yukitoshi| Miura, Ayane| Sakamoto, Tatsuya| Takanami, Keiko| Sakamoto, Hirotaka| |
| Keywords | itchy eyes histamine gastrin-releasing peptide receptor footedness |
| Published Date | 2022-10-19 |
| Publication Title | Proceedings of the Royal Society B: Biological Sciences |
| Volume | volume289 |
| Issue | issue1985 |
| Publisher | The Royal Society |
| Start Page | 20221126 |
| ISSN | 0962-8452 |
| NCID | AA00786976 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s) |
| File Version | author |
| PubMed ID | 36259204 |
| DOI | 10.1098/rspb.2022.1126 |
| Web of Science KeyUT | 000872392900003 |
| Related Url | isVersionOf https://doi.org/10.1098/rspb.2022.1126 |
| FullText URL | fulltext20221116-2.pdf |
|---|---|
| Author | Gotoh, Kazuyoshi| Hagiya, Hideharu| Iio, Koji| Yamada, Haruto| Matsushita, Osamu| Otsuka, Fumio| |
| Keywords | Antimicrobial resistance Carbapenemase-producing Enterobacterales Carbapenem-resistant Enterobacterales New Delhi metallo-β-lactamase (NDM) Enterobacter cloacae complex |
| Note | © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.08.019] .| This full-text will be available in Oct. 2023.| |
| Published Date | 2022-12 |
| Publication Title | Journal of Infection and Chemotherapy |
| Volume | volume28 |
| Issue | issue12 |
| Publisher | Elsevier BV |
| Start Page | 1697 |
| End Page | 1699 |
| ISSN | 1341-321X |
| NCID | AA11057978 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. |
| File Version | author |
| PubMed ID | 36049614 |
| DOI | 10.1016/j.jiac.2022.08.019 |
| Web of Science KeyUT | 000874559900019 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2022.08.019 |
| FullText URL | fulltext20221116-1.pdf |
|---|---|
| Author | Takahashi, Misa| Hagiya, Hideharu| Koyama, Toshihiro| Otsuka, Fumio| |
| Keywords | aging sexual health sexually transmitted infection spirochete syphilis |
| Note | This is the peer reviewed version of the following article: [Takahashi, M, Hagiya, H, Koyama, T, Otsuka, F. Trends in the incidence of syphilis in the middle-aged and older adults in Japan: A nationwide observational study, 2009–2019. Geriatr. Gerontol. Int. 2022; 22: 1019–1024. https://doi.org/10.1111/ggi.14500], which has been published in final form at [https://doi.org/10.1111/ggi.14500]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This full-text will be available in Nov. 2023.| |
| Published Date | 2022-11-01 |
| Publication Title | Geriatrics and Gerontology International |
| Volume | volume22 |
| Issue | issue12 |
| Publisher | Wiley |
| Start Page | 1019 |
| End Page | 1024 |
| ISSN | 1444-1586 |
| NCID | AA1155729X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Japan Geriatrics Society. |
| File Version | author |
| PubMed ID | 36320169 |
| DOI | 10.1111/ggi.14500 |
| Web of Science KeyUT | 000877369900001 |
| Related Url | isVersionOf https://doi.org/10.1111/ggi.14500 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tsuge, Mitsuru| Kodera, Aya| Sumitomo, Hiromi| Araki, Tooru| Yoshida, Ryuichi| Yasui, Kazuya| Sato, Hiroki| Washio, Yosuke| Washio, Kana| Shigehara, Kenji| Yashiro, Masato| Yagi, Takahito| Tsukahara, Hirokazu| |
| Keywords | Neonatal hemochromatosis Thalassemia Liver transplantation Gestational alloimmune liver disease Case report Hepcidin Ineffective erythropoiesis Growth differentiation factor-15 |
| Published Date | 2022-10-29 |
| Publication Title | BMC Pediatrics |
| Volume | volume22 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 622 |
| ISSN | 1471-2431 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 36309641 |
| DOI | 10.1186/s12887-022-03706-3 |
| Web of Science KeyUT | 000876287400002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12887-022-03706-3 |
| FullText URL | fulltext20221110-3.pdf |
|---|---|
| Author | Nakano, Yumiko| Taira, Yuki| Sasaki, Ryo| Tadokoro, Koh| Yunoki, Taijun| Nomura, Emi| Fukui, Yusuke| Takemoto, Mami| Morihara, Ryuta| Shimozawa, Nobuyuki| Yamashita, Toru| |
| Keywords | adrenoleukodystrophy symptomatic female carriers spastic paraplegia ABCD1 |
| Note | This is the peer reviewed version of the following article: [Nakano, Y, Taira, Y, Sasaki, R, et al. Novel ABCD1 mutation detected in a symptomatic female carrier of adrenoleukodystrophy. Neurol Clin Neurosci. 2023; 11: 58-60. doi: 10.1111/ncn3.12667], which has been published in final form at [https://doi.org/10.1111/ncn3.12667]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| Published Date | 2022-10-17 |
| Publication Title | Neurology and Clinical Neuroscience |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | 58 |
| End Page | 60 |
| ISSN | 2049-4173 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd. |
| File Version | author |
| DOI | 10.1111/ncn3.12667 |
| Web of Science KeyUT | 000868833900001 |
| Related Url | isVersionOf https://doi.org/10.1111/ncn3.12667 |
| FullText URL | fulltext20221110-3.pdf |
|---|---|
| Author | Shimomae, Koichi| Sato, Takuya| Yoshida, Yuichi| Naing, Shine Shane| Miyatake, Takahisa| |
| Keywords | Diptera Lifespan Pollination Quality control |
| Note | © 2022 Korean Society of Applied Entomology. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.aspen.2022.101999] .| This full-text file will be available in Oct. 2023.| |
| Published Date | 2022-12 |
| Publication Title | Journal of Asia-Pacific Entomology |
| Volume | volume25 |
| Issue | issue4 |
| Publisher | Elsevier BV |
| Start Page | 101999 |
| ISSN | 1226-8615 |
| NCID | AA11262547 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Korean Society of Applied Entomology. |
| File Version | author |
| DOI | 10.1016/j.aspen.2022.101999 |
| Web of Science KeyUT | 000868905600009 |
| Related Url | isVersionOf https://doi.org/10.1016/j.aspen.2022.101999 |
| FullText URL | fulltext20221114-1.pdf |
|---|---|
| Author | Isobe, Hiroshi| Shoji, Mitsuo| Suzuki, Takayoshi| Shen, Jian-Ren| Yamaguchi, Kizashi| |
| Note | This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry B, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jpcb.2c02596| This full-text will be available in Sep. 2023.| |
| Published Date | 2022-09-15 |
| Publication Title | The Journal of Physical Chemistry B |
| Volume | volume126 |
| Issue | issue38 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 7212 |
| End Page | 7228 |
| ISSN | 1520-6106 |
| NCID | AA11114073 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 American Chemical Society |
| File Version | author |
| PubMed ID | 36107406 |
| DOI | 10.1021/acs.jpcb.2c02596 |
| Web of Science KeyUT | 000863255500001 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.jpcb.2c02596 |
| JaLCDOI | 10.18926/AMO/64127 |
|---|---|
| FullText URL | 76_6_749.pdf |
| Author | Takami, Masanari| Yukawa, Yasutsugu| Noda, Yusuke| Yoshida, Munehito| Yamada, Hiroshi| |
| Abstract | We provide the first report of successful salvage surgery for a post-C1 laminectomy symptomatic recurrence of a retro-odontoid pseudotumor (ROP) that caused myelopathy. The 72-year-old Japanese woman presented with an ROP causing symptomatic cervical myelopathy. With ultrasonography support, we performed the enucleation of the ROP via a transdural approach and fusion surgery for the recurrence of the mass. At the final observation 2-year post-surgery, MRI demonstrated the mass’s regression and spinal cord decompression, and the patient’s symptoms had improved. Our strategy is an effective option for a symptomatic recurrence of ROP. |
| Keywords | recurrent retro-odontoid pseudotumor salvage surgery transdural resection C1 laminectomy ultra-sonography |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 749 |
| End Page | 754 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549779 |
| Web of Science KeyUT | 000905195100017 |
| JaLCDOI | 10.18926/AMO/64126 |
|---|---|
| FullText URL | 76_6_743.pdf |
| Author | Tanaka, Masato| Suthar, Hardik| Desai, Dhvanit| Yamauchi, Taro| Arataki, Shinya| Fujiwara, Yoshihiro| Uotani, Koji| Oda, Yoshiaki| Misawa, Haruo| |
| Abstract | We describe a floating technique via a posterolateral approach with intraoperative O-arm navigation to facilitate decompression of the spinal cord in thoracic myelopathy due to severe ossification of the posterior longitudinal ligament (OPLL). A 62-year-old man with myelopathy due to thoracic OPLL had left-leg muscle weakness, urinary disturbance, and spastic gait. Bilateral leg pain and gait disturbance had persisted for 2 years. He was successfully treated by the posterolateral OPLL floating procedure and posterior pedicle fixation under O-arm navigation. At a 2-year follow-up, manual muscle testing results and sensory function of the left leg had recovered fully. His cervical Japanese Orthopedic Association score had improved from 5/12 to 11/12. The novel intraoperative O-arm navigation-guided posterolateral floating procedure for thoracic OPLL is effective for achieving precise decompression and strong fixation with a posterior approach only and can provide an excellent result for severe thoracic OPLL without the risk of adverse events from intraoperative radiation. |
| Keywords | ossification of the posterior longitudinal ligament floating method navigation surgery C-arm free |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 743 |
| End Page | 748 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549778 |
| Web of Science KeyUT | 000905195100016 |
| JaLCDOI | 10.18926/AMO/64125 |
|---|---|
| FullText URL | 76_6_737.pdf |
| Author | Yamaoka, Masakazu| Yamamoto, Yumi| Minami, Eriko| |
| Abstract | Paraplegia after an operation for acute aortic dissection Stanford type A (AADA) is fairly uncommon, and there is no consensus about optimal treatment. We present a case in which cerebrospinal fluid drainage (CSFD) and permissive hypertension were used for treatment of paraplegia. When the patient showed complete bilateral paraplegia after operation for AADA, we immediately began CSFD and maintained mean arterial blood pressure at over 90 mmHg. His neurological deficit gradually recovered, and he was eventually able to walk without support. The combination of CSFD and permissive hypertension could be a first-line emergent treatment for postoperative paraplegia after AADA surgery. |
| Keywords | paraplegia acute aortic dissection cerebrospinal drainage permissive hypertension |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 737 |
| End Page | 742 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549777 |
| Web of Science KeyUT | 000905195100015 |
| JaLCDOI | 10.18926/AMO/64124 |
|---|---|
| FullText URL | 76_6_731.pdf |
| Author | Kamamura, Maho| Higaki, Fumiyo| Sasada, Susumu| Matsushita, Toshi| Yasuhara, Takao| Date, Isao| Hiraki, Takao| |
| Abstract | We report a rare case of idiopathic spinal cord herniation (ISCH) with a history of cerebrospinal fluid (CSF) leakage. ISCH is a protrusion of the spinal cord through a dural defect. Thin constructive interference in steady-state (CISS) images clearly demonstrated the herniated cord in the present case. The myelopathy worsened and the patient underwent surgery for reduction of herniated spinal cord; the dural defect was filled by placing collagen matrix graft (DuraGen®) between the inner and outer dural layers. The patient’s symptoms have improved without relapse for 8 months since surgery. This method may be a good surgical option for cases of spinal cord herniation. |
| Keywords | cerebrospinal fluid leakage constructive interference in steady state collagen matrix graft magnetic resonance image spinal cord herniation |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 731 |
| End Page | 736 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549776 |
| Web of Science KeyUT | 000905195100014 |
| JaLCDOI | 10.18926/AMO/64123 |
|---|---|
| FullText URL | 76_6_723.pdf |
| Author | Zhang, Quan| Yang, Lixia| Wan, Guozhen| Zhang, Xiaoqiang| Wang, Ying| Zhao, Guannan| |
| Abstract | The diagnostic value of microRNA-377 (miR-377) in patients with acute coronary syndrome (ACS) and explored miR-377’s potential mechanisms. We performed an qRT-PCR to assess serum miR-377 levels in ACS patients and coronary artery ligation rat models. The diagnostic value of miR-377 was evaluated by determining the ROC curve. An ELISA assay was conducted to detect the model rat endothelial damage markers von Willebrand factor (vWF) and heart-type fatty acid binding protein (H-FABP), and proinflammatory cytokines TNF-α, IL-6, and IL-1β. The serum miR-377 level was elevated in the ACS patients and significantly increased in the ACS rats. MiR-377 has a high diagnostic value in ACS patients, with a 0.844 ROC, 76.47% specificity, and 87.10% sensitivity. MiR-377 was positively correlated with the expressions of vWF, H-FABP, cTnI, TNF-α, IL-6, and IL-1β. In ACS rats, reducing the expression of miR-377 significantly inhibited the increases in vWF, H-FABP, TNF-α, IL-6, and IL-1β. An elevated miR-377 level can be used as a diagnostic marker in patients with ACS. A reduction of miR-377 may alleviate ACS by improving myocardial damage such as endothelial injury and the inflammatory response. |
| Keywords | microRNA-377 acute coronary syndrome diagnosis endothelial injury inflammatory |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 723 |
| End Page | 730 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549775 |
| Web of Science KeyUT | 000905195100013 |
| JaLCDOI | 10.18926/AMO/64122 |
|---|---|
| FullText URL | 76_6_715.pdf |
| Author | Mohammed Zahedul Islam Nizami| Gorduysus, Melahat| Shinoda-Ito, Yuki| Yamamoto, Tadashi| Nishina, Yuta| Takashiba, Shogo| Arias, Zulema| |
| Abstract | The failure of endodontic treatment is directly associated with microbial infection in the root canal or periapical areas. An endodontic sealer that is both bactericidal and biocompatible is essential for the success of root canal treatments. This is one of the vital issues yet to be solved in clinical dental practice. This in vitro study assessed the effectiveness of graphene oxide (GO) composites GO-CaF2 and GO-Ag-CaF2 as endodontic sealer materials. Dentin slices were coated with either the GO-based composites or commonly used root canal sealers (non-eugenol zinc oxide sealer). The coated slices were treated in 0.9% NaCl, phosphate-buffered saline (PBS), and simulated body fluid (SBF) at 37˚C for 24 hours to compare their sealing effect on the dentin surface. In addition, the radiopacity of these composites was examined to assess whether they complied with the requirements of a sealer for good radiographic visualization. Scanning electron microscopy showed the significant sealing capability of the composites as coating materials. Radiographic images confirmed their radiopacity. Mineral deposition indicated their bioactivity, especially of GO-Ag-CaF2, and thus it is potential for regenerative application. They were both previously shown to be bactericidal to oral microbes and cytocompatible with host cells. With such a unique assemblage of critical properties, these GO-based composites show promise as endodontic sealers for protection against reinfection in root canal treatment and enhanced success in endodontic treatment overall. |
| Keywords | bioactive sealer graphene oxide mineral deposition antimicrobial activity radiopacity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 715 |
| End Page | 721 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549774 |
| Web of Science KeyUT | 000905195100012 |
| JaLCDOI | 10.18926/AMO/64121 |
|---|---|
| FullText URL | 76_6_705.pdf |
| Author | Higashikawa, Toshihiro| Ito, Tomohiko| Mizuno, Takurou| Ishigami, Keiichiro| Kuroki, Kengo| Maekawa, Naoto| Usuda, Daisuke| Izumida, Toshihide| Yamada, Shinya| Sangen, Ryusho| Hamada, Kazu| Kiyosawa, Jun| Saito, Atsushi| Iguchi, Masaharu| Kasamaki, Yuji| Nakahashi, Takeshi| Fukuda, Akihiro| Saito, Hitoshi| Kanda, Tsugiyasu| Okuro, Masashi| |
| Abstract | The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin’s osmotic diuresis mechanism, patients’ serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (β1=−0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e’ tended to decrease (β1=−0.382, p=0.13, LRA). Compared to the baseline, E/e’ was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e’ group (E/e’≥10, n=34), E/e’ decreased significantly (β1=−0.63, p<0.05, LRA). ΔE/e’ was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e’ in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function. |
| Keywords | tofogliflozin SGLT2 inhibitor elderly patient HbA1c cardiac diastolic function |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 705 |
| End Page | 713 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549773 |
| Web of Science KeyUT | 000905195100011 |
| JaLCDOI | 10.18926/AMO/64120 |
|---|---|
| FullText URL | 76_6_695.pdf |
| Author | Onishi, Hideki| Nouso, Kazuhiro| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Takeuchi, Yasuto| Shiraha, Hidenori| Okada, Hiroyuki| |
| Abstract | This study sought to identify factors that are predictive of a therapeutic response to hepatic arterial infusion chemotherapy (HAIC) by focusing on the number of prior transcatheter arterial chemoembolization (TACE) sessions. To determine the parameters predicting a good response to HAIC, we retrospectively analyzed 170 patients with hepatocellular carcinoma (HCC) who received HAIC regimens comprising low-dose cisplatin combined with 5-fluorouracil (LFP) or cisplatin (CDDP) for the first time. In both the LFP and CDDP regimens, the response rates were significantly lower in patients with three or more prior TACE sessions than in those with two or fewer prior TACE sessions (LFP 57% versus 28%; p=0.01, CDDP 27% versus 6%; p=0.01). Multivariable logistic regression analysis revealed that the number of prior TACE sessions (≥ 3) was significantly associated with non-responder status (odds ratio 4.17, 95% Confidence Interval (CI) 1.76-9.86) in addition to the HAIC regimen. Multivariable analysis using the Cox proportional hazards model revealed that a larger number of prior TACE sessions (≥ 3) was a significant risk factor for survival (hazard ratio 1.60, 95% CI 1.12-2.29) in addition to Child-Pugh class, serum alpha-fetoprotein concentration, and maximum diameter of HCC. HCC patients who receive fewer prior TACE sessions (≤ 2) were found to be better responders to HAIC. |
| Keywords | hepatic arterial infusion chemotherapy hepatocellular carcinoma refractory transcatheter arterial chemoembolization |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 695 |
| End Page | 703 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549772 |
| Web of Science KeyUT | 000905195100010 |
