| ID | 67497 |
| Author |
Tokushige, Keisuke
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Abe, Takumi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Kaken ID
researchmap
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| Abstract | Unprecedented tert-BuOK-mediated one carbon deletion of indoline hemiaminals has been achieved. This novel protocol provides an efficient synthetic tool for the construction of 2-aminobenzyl compounds with high chemoselectivity. In addition, functionalized 2-aminobenzyl compounds are difficult to make, for which few limited means of access currently exist. The key to success is the use of in situ generated Heyns rearrangement products (α-amino carbonyl compounds) as precursors for formal one carbon deletion.
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| Note | This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright © 2024 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.4c00884.
This fulltext file will be available in Jun. 2025.
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| Published Date | 2024-07-01
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| Publication Title |
The Journal of Organic Chemistry
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| Volume | volume89
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| Issue | issue14
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| Publisher | American Chemical Society (ACS)
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| Start Page | 10349
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| End Page | 10354
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| ISSN | 0022-3263
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| NCID | AA00704100
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | © 2024 American Chemical Society
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| File Version | author
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| PubMed ID | |
| DOI | |
| Web of Science KeyUT | |
| Related Url | isVersionOf https://doi.org/10.1021/acs.joc.4c00884
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| Funder Name |
Japan Society for the Promotion of Science
Japan Science and Technology Agency
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| 助成番号 | 22K06503
JPMJSP2126
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