ラットの耐糖能,インスリン反応およびインスリン感受性に及ぼす高脂肪食および低脂肪食と運動の影響

To investigate the interrelationships between the westernized diet and physical exercise as they affect the development of non-insulin-dependent diabetes mellitus (NIDDM), adiposity, glucose tolerance and insulin response to an intraperitoneal glucose load (1.5g/kg bw) and insulin sensitivity to exogenous insulin (0.2U/kg bw) were studied in spontaneously exercised and sedentary rats fed either a high fat diet (40% fat, modern western type) or a low fat diet (10% fat, traditional Japanese type). The high fat diet, compared with the low fat diet, increased the deposition of epididymal fat pads in exercised and sedentary rats. Physical exercise decreased the deposition of fat pads in the high and low fat diet rats. The high fat dier, compared with the low fat diet, increased glucose-stimulated glucose and insulin levels in the exercised and sedentary rats. Physical exercise led to reductions in glucose-stimulated glucose and insulin levels in the high and low fat diet rats. The high fat diet, compared with the low fat diet, decreased insulin sensitivity to exogenous insulin in the exercised and sedentary rats. Physical exercise increased insulin sensitivity in the high and low fat diet rats. Physical exercised rats fed the high fat diet and the sedentary rats fed the low fat diet had simular adiposity, glucose tolerance and insulin sensitivity. These data indicated that both the high fat diet and lack of physical exercise strongly affect the development of NIDDM.