result 1313 件
| JaLCDOI | 10.18926/AMO/62229 |
|---|---|
| FullText URL | 75_3_345.pdf |
| Author | Koyama, Kanae| Miura, Noriyoshi| Watanabe, Ryuta| Sawada, Yuichiro| Noda, Terutaka| Nishimura, Kenichi| Asai, Seiji| Fukumoto, Tetsuya| Yanagihara, Yutaka| Miyauchi, Yuki| Kikugawa, Tadahiko| Saika, Takashi| |
| Abstract | The management of blood pressure is a significant concern for surgeons and anesthesiologists performing adrenalectomy for pheochromocytoma. We evaluated clinical factors in pheochromocytoma patients to identify the predictors of postoperative hypotension. The medical records of patients who underwent adrenalectomy for pheochromocytoma between 2001 and 2017 were retrospectively reviewed and clinical and biochemical data were evaluated. Of 29 patients, 13 patients needed catecholamine support in the perisurgical period while 16 patients did not. There were significant differences in median age, tumor size, and blood pressure drop (maxmin) between the 2 groups (68 vs 53 years old, p=0.045; 50 vs 32 mm diameter, p=0.022; 110 vs 71 mmHg, p=0.015 respectively). In univariate logistic analysis, age > 65.5 years, tumor size > 34.5 mm, urine metanephrine > 0.205 mg/day and urine normetanephrine > 0.665 mg/day were significant predictors of prolonged hypotension requiring postoperative catecholamine support. Tumor size and urine metanephrine and urine normetanephrine levels were correlated with postoperative hypotension. These predictors may help in the safe perioperative management of pheochromocytoma patients treated with adrenalectomy. |
| Keywords | urinary metanephrine urinary normetanephrine adrenalectomy pheochromocytoma |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 345 |
| End Page | 349 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176938 |
| Web of Science KeyUT | 000667147700009 |
| NAID | 120007089826 |
| JaLCDOI | 10.18926/AMO/62228 |
|---|---|
| FullText URL | 75_3_335.pdf |
| Author | Chikuie, Nobuyuki| Hamamoto, Takao| Ueda, Tsutomu| Taruya, Takayuki| Kono, Takashi| Furuie, Hiromi| Ishino, Takashi| Takeno, Sachio| |
| Abstract | Recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC) has a poor prognosis. Although nivolumab is approved in Japan for treating R/MHNSCC, the response rate is low. Therefore, identifying pretreatment prognostic factors is necessary. This study assessed the utility of the neutrophil-to-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS) as biomarkers of response to nivolumab. We retrospectively collected the data of 56 R/MHNSCC patients treated with nivolumab between May 2017 and December 2019. The Kaplan–Meier method and log-rank test were used to estimate overall survival (OS) and progression-free survival (PFS), and multivariate Cox hazard regression analysis was used to identify independent predictors of survival. Patients with a low pretreatment NLR had prolonged OS, and patients with a low pretreatment GPS had increased OS and PFS. A performance score (PS) of 0-1, development of immune-related adverse events, and GPS of 0-1 were significantly associated with OS in multivariate analysis. In summary, baseline pretreatment NLR and GPS are independently associated with OS in R/MHNSCC patients treated with nivolumab. Administration of nivolumab while maintaining the PS reflects a immune status of the host and leads to a good OS. |
| Keywords | neutrophil-to-lymphocyte ratio nivolumab Glasgow Prognostic Score recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 335 |
| End Page | 343 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176937 |
| Web of Science KeyUT | 000667147700008 |
| NAID | 120007089825 |
| JaLCDOI | 10.18926/AMO/62227 |
|---|---|
| FullText URL | 75_3_323.pdf |
| Author | Furutani, Michiyo| Yu, Zhou| Nakatsuka, Mikiya| |
| Abstract | Gender expression is important for transgender women to improve their social passing as women. Herein, a questionnaire about the status of gender expression and support needs was distributed to 54 transgender women aged 17-71 in Japan. Most of the respondents noted that they had found it relatively difficult to handle physical changes and weight gain due to hormone treatment. They also found it difficult to enact and sustain practices such as a feminine use of voice and to use women-only services, whereas practicing and continuing with routine skin and hair care and feminine mannerisms were relatively easy for them. In the questionnaire regarding the support for gender transitioning, many items showed only a small percentage of the transgender women had received the support that they were looking for, and most of their needs for support were not addressed. Some of the factors that increased the respondents’ needs and achievement of gender expression as women included estrogen treatment, sex reassignment surgery, and living as a woman; these aspects met their support needs as well. Gender support professionals need to coordinate and collaborate with specialists in areas such as nutritional guidance and voice training to enable transgender women to improve the extent to which they can socially ‘pass’ as women. |
| Keywords | transgender gender expression social passing as a woman real life experience gender transition |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 323 |
| End Page | 334 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176936 |
| Web of Science KeyUT | 000667147700007 |
| NAID | 120007089824 |
| JaLCDOI | 10.18926/AMO/62226 |
|---|---|
| FullText URL | 75_3_315.pdf |
| Author | Wada, Riho| Fujiwara, Masaki| Yamada, Yuto| Nakaya, Naoki| Fujimori, Maiko| So, Ryuhei| Kodama, Masafumi| Higuchi, Yuji| Kakeda, Kyoko| Uchitomi, Yosuke| Yamada, Norihito| Inagaki, Masatoshi| |
| Abstract | It is necessary to assess functional impairment when treating schizophrenia. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) has been adopted as a measure of functional disability in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. This study was a secondary analysis from a cross-sectional study of health-related behaviors among patients with schizophrenia. We examined the validity and reliability of the Japanese version of the 12-item WHODAS 2.0 when self-administered by such patients. Participants were 350 outpatients with schizophrenia from a psychiatric hospital. The standard six-factor structure of the WHODAS 2.0 showed a good fit for these participants. The Cronbach’s alpha coefficient was 0.858, showing good internal consistency. The WHODAS 2.0 showed moderate correlations with the modified Global Assessment of Functioning and Kessler 6 scales (r=−0.434 and 0.555, respectively). The results of this study show that the Japanese version of the 12-item self-administered WHODAS 2.0 has good internal consistency and convergent validity among patients with schizophrenia. Further exploration of the usefulness of WHODAS 2.0 in clinical settings is needed. |
| Keywords | disability schizophrenia validity reliability WHODAS 2.0 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 315 |
| End Page | 322 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176935 |
| NAID | 120007089823 |
| JaLCDOI | 10.18926/AMO/62225 |
|---|---|
| FullText URL | 75_3_307.pdf |
| Author | Ishizaka, Hinata| Kuroda, Masahiro| Tekiki, Nouha| Khasawneh, Abdullah| Barham, Majd| Hamada, Kentaro| Konishi, Kohei| Sugimoto, Kohei| Katsui, Kuniaki| Sugiyama, Soichi| Watanabe, Kenta| Yoshio, Kotaro | Katayama, Norihisa| Ogata, Takeshi| Ihara, Hiroki| Oita, Masataka| Kanazawa, Susumu| Asaumi, Junichi| |
| Abstract | Reports on irradiation dose distribution in breast cancer radiotherapy with sufficient sample size are limited in Asian patients. Elucidating dose distribution in Asian patients is particularly important as their breast volume differs compared to patients in Europe and North America. Here, we examined dose distribution in the irradiation field relative to breast volume for three irradiation methods historically used in our facility. We investigated the influence of breast volume on each irradiation method for Asian women. A total of 573 women with early-stage breast cancer were treated with breast-conserving surgery and adjuvant radiotherapy. Three methods were compared: wedge (W), field-in-field (FIF), and wedge-field-in-field (W-FIF). In patients with small breast volume, FIF decreased low- and high-dose areas within the planning target volume, and increased optimal dose area more than W. In patients with medium and large breast volumes, FIF decreased high-dose area more than W. The absolute values of correlation coefficients of breast volume to low-, optimal-, and high-dose areas and mean dose were significantly lower in FIF than in W. The correlation coefficients of V107% were 0.00 and 0.28 for FIF and W, respectively. FIF is an excellent irradiation method that is less affected by breast volume than W in Asian breast cancer patients. |
| Keywords | breast cancer radiotherapy dose distribution irradiation method breast volume |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 307 |
| End Page | 314 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176934 |
| Web of Science KeyUT | 000667147700006 |
| NAID | 120007089838 |
| JaLCDOI | 10.18926/AMO/62221 |
|---|---|
| FullText URL | 75_3_299.pdf |
| Author | Araki, Jo| Oka, Kosuke| Yamamoto, Koichiro| Hanayama, Yoshihisa | Tokumasu, Kazuki| Hagiya, Hideharu| Ogawa, Hiroko| Itoshima, Koichi| Otsuka, Fumio| |
| Abstract | Various laboratory markers of inflammation are utilized in general practice, but their clinical diagnostic significance is often ambiguous. In the present study, we determined the clinical significance of the examination of serum levels of procalcitonin (PCT) by comparing the PCT levels with the levels of other inflammatory markers, based on a retrospective review of 332 PCT-positive patients, including cases of bacterial infection (20.5%), non-specific inflammation (20.8%), neoplasm (9.9%), connective tissue diseases (8.4%), and non-bacterial infection (7.2%), were analyzed. The serum PCT level was highest in the bacterial infection group (1.94 ng/ml) followed by the non-specific inflammatory group (0.58 ng/ml) and neoplastic diseases group (0.34 ng/ml). The serum PCT level was positively correlated with serum levels of C-reactive protein (rho=0.62), soluble interleukin-2 receptor (sIL-2R; rho=0.69), and ferritin, the plasma level of D-dimer, and white blood cell count, and negatively correlated with the serum albumin level (rho=−0.52), hemoglobin concentration, and platelet count. The serum PCT level showed a stronger positive correlation with the serum sIL-2R level than the other biomarkers. The results suggest that an increased PCT level may indicate not only an infectious state but also a non-bacterial inflammatory condition in the diagnostic process in general practice. |
| Keywords | bacterial infection inflammation malignant lymphoma procalcitonin soluble interleukin-2 receptor |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 299 |
| End Page | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176933 |
| Web of Science KeyUT | 000667147700005 |
| NAID | 120007089836 |
| JaLCDOI | 10.18926/AMO/62220 |
|---|---|
| FullText URL | 75_3_289.pdf |
| Author | Miyamoto, Masakazu| Osawa, Kazuhiro| Miyoshi, Toru| Mori, Atsushi| Yoshikawa, Masaki| Oka, Takefumi| Ichikawa, Keishi| Nakamura, Kazufumi| Ito, Hiroshi| |
| Abstract | Early treatment with an oral β-blocker is recommended in patients with a ST-segment–elevation myocardial infarction (STEMI). In this multicenter study, we evaluated the effects of a continuous administration of landiolol, an ultrashort-acting β-blocker, before primary percutaneous coronary intervention (PCI) on myocardial salvage and its safety in STEMI patients. A total of 47 Japanese patients with anterior or lateral STEMI undergoing a primary PCI within 12 h of symptom onset were randomized to receive intravenous landiolol (started at 3 μg/min/kg dose and continued to a total of 50 mg; n=23) or not (control; n=24). Patients with Killip class III or more were excluded. The primary outcome was the myocardial salvage index on cardiac magnetic resonance imaging (MRI) performed 5-7 days after the PCI. Cardiac MRI was performed in 35 patients (74%). The myocardial salvage index in the landiolol group was significantly greater than that in the control group (44.4±14.6% vs. 31.7±18.9%, respectively; p=0.04). There were no significant differences in adverse events at 24 h between the landiolol and control groups. A continuous administration of landiolol before a primary PCI may increase the degree of myocardial salvage without additional hemodynamic adverse effects within the first 24 h after STEMI. |
| Keywords | myocardial infarction landiolol magnetic resonance imaging STEMI PCI |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 289 |
| End Page | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176932 |
| Web of Science KeyUT | 000667147700004 |
| NAID | 120007089835 |
| JaLCDOI | 10.18926/AMO/62219 |
|---|---|
| FullText URL | 75_3_279.pdf |
| Author | Nishinohara, Masa-aki| Nishimori, Hisakazu| Fujiwara, Hideaki| Asada, Noboru| Ennishi, Daisuke| Matsuoka, Ken-ichi| Fujii, Keiko| Fujii, Nobuharu| Maeda, Yoshinobu| |
| Abstract | A bloodstream infection (BSI) is the most common serious infectious complication of hematopoietic stem cell transplantation (HSCT). BSI promotes an inflammatory state, which exacerbates acute graft-versus-host disease (GVHD). We investigated whether a Gram-negative rod bloodstream infection (GNR-BSI), which develops early after allo-HSCT, affected the onset or exacerbated acute GVHD in 465 patients who underwent allo-HSCT from 1995 through 2015 at a single institution. Eighty-eight patients (19%) developed BSI during the study period. Among the cultures, 50 (57%) were Gram-positive cocci (GPC) and 31 (35%) were GNR. Of the 465 patients, 187 (40%) developed acute GVHD of grade II or higher within the first 100 days post-allogeneic HSCT: 124 (27%) had acute GVHD grade II, 47 (10%) had grade III, and 16 (3%) had grade IV. Multivariate analysis revealed that GNR-BSI was a significant risk factor for grade II-IV acute GVHD (grade II-IV: hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.03-2.97; grade III-IV: HR 2.37, 95% CI 1.03-5.43). These results suggest that GNR-BSI may predict the onset and exacerbation of acute GVHD. |
| Keywords | blood stream infection graft-versus-host disease gram negative rods |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 287 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176931 |
| Web of Science KeyUT | 000667147700003 |
| NAID | 120007089834 |
| JaLCDOI | 10.18926/AMO/62218 |
|---|---|
| FullText URL | 75_3_269.pdf |
| Author | Katsui, Kuniaki| Ogata, Takeshi| Watanabe, Kenta| Yoshio, Kotaro| Kuroda, Masahiro| Hiraki, Takao| Kiura, Katsuyuki| Maeda, Yoshinobu| Toyooka, Shinichi| Kanazawa, Susumu| |
| Abstract | Palliative concurrent chemoradiotherapy (CCRT) is often administered to patients with stage III non-small cell lung cancer (NSCLC). We investigated the clinical outcomes of patients receiving palliative CCRT for NSCLC. Data of patients with NSCLC who underwent palliative CCRT (n=16), preoperative CCRT plus surgery (n=97), or definitive CCRT (n=48) were evaluated. In all groups, the concurrent chemotherapy regimens consisted of cisplatin and docetaxel. Rates of local control (LC), distant metastasis-free survival (DMFS), progression-free survival (PFS), overall survival (OS), and prognosis were compared. The 2-year rates of LC, DMFS, PFS, and OS in 16 patients who underwent palliative CCRT were 44.4%, 12.5%, 12.5%, and 18.8%, respectively. Univariate analysis showed that palliative CCRT was associated with poor LC (p<0.001), DMFS (p<0.001), PFS (p<0.001), and OS (p<0.001) outcomes in patients who completed CCRT as a preoperative treatment and poor LC (p=0.01), DMFS (p=0.003), PFS (p=0.04), and OS (p=0.004) outcomes in patients who were considered for definitive CCRT. Although there were some long-term survivors, the clinical outcomes of palliative CCRT were significantly inferior to those of the ideal treatments. Therefore, careful determination of the appropriate treatment indications and further studies are warranted. |
| Keywords | palliative concurrent chemoradiotherapy cisplatin/docetaxel stage III non-small cell lung cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 269 |
| End Page | 277 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176930 |
| Web of Science KeyUT | 000667147700002 |
| NAID | 120007089833 |
| JaLCDOI | 10.18926/AMO/62217 |
|---|---|
| FullText URL | 75_3_261.pdf |
| Author | Arapovic, Lidija Lasic| Karlovic, Zoran| Brzovic, Valentina Rajic| Bukvic, Amer| Coric, Anka| Vukojevic, Katarina| Verzak, Zeljko| |
| Abstract | We conducted a retrospective analysis of records of special needs patients (SNPs) who received dental treatment under orotracheal-intubation general anaesthesia (OIGA) at Caritas Centre St. Family in Mostar, Bosnia and Herzegovina during the 14-year period from January 2005 to December 2018. Of the 7,085 SNPs who received dental treatment, 1,220 (17.2%) received dental treatment under OIGA: 829 (67.9%) males and 391 (32.1%) females. The patients’ mean age was 18.3±10.9 years (747 paediatric and 473 adult patients). Mental retardation and psychiatric problems were the most common medical conditions (81.22%). The most common indication for dental treatment under OIGA was behaviour management (87.21%), and 81% of the patients had an urgent need for treatment. Many of the patients had restorative treatment (3,833) and tooth extractions (3,681). From 2011 onwards, the number of tooth extractions decreased significantly. Annual trends revealed a rapid increase of patients every year. The mean dental treatment duration was 95.3±12.1 min; the mean time under OIGA was 98±8.5 min. No serious adverse effects occurred. There was increase of annual trend of SNP in OIGA. The number of extractions decreased while the number of preventive and restorative dental treatments increased. |
| Keywords | special needs patients general anaesthesia dental treatment dental care mental retardation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 261 |
| End Page | 268 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176929 |
| Web of Science KeyUT | 000667147700001 |
| NAID | 120007089832 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ise, Masato| Nakata, Eiji| Katayama, Yoshimi| Hamada, Masanori| Kunisada, Toshiyuki| Fujiwara, Tomohiro| Nakahara, Ryuichi| Takihira, Shouta| Sato, Kohei| Akezaki, Yoshiteru| Senda, Masuo| Ozaki, Toshifumi| |
| Keywords | psychological distress distress and impact thermometer bone and soft tissue tumor surgery |
| Published Date | 2021-05-01 |
| Publication Title | Healthcare |
| Volume | volume9 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 566 |
| ISSN | 2227-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| NAID | 120007042388 |
| DOI | 10.3390/healthcare9050566 |
| Web of Science KeyUT | 000654015500001 |
| Related Url | isVersionOf https://doi.org/10.3390/healthcare9050566 |
| JaLCDOI | 10.18926/AMO/61909 |
|---|---|
| FullText URL | 75_2_249.pdf |
| Author | Sun, Weiying| Shiode, Yusuke| Tokumasu, Kazuki| Kimura, Shuhei| Hosokawa, Mio| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Otsuka, Fumio| Morizane, Yuki| |
| Abstract | A 79-year-old woman presented to our hospital with a 10-day history of gradually worsening binocular vision and severe backache. Further investigations revealed poor bilateral best-corrected visual acuities (BCVA), bilateral vitreous opacities, gray-white lesions scattered throughout the retina, and a left iliopsoas abscess on CT that later grew out methicillin-sensitive S. aureus. The abscess was drained and intravenous antibiotics were initiated, but the left eye additionally required intravitreal vancomycin. BCVA for both eyes normalized within 1 year. Intramuscular abscess should be considered as a possible primary lesion in cases of endogenous bacterial endophthalmitis. |
| Keywords | endogenous bacterial endophthalmitis methicillin-sensitive Staphylococcus aureus iliopsoas abscess intravitreal injection vancomycin |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 249 |
| End Page | 253 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953434 |
| NAID | 120007029878 |
| JaLCDOI | 10.18926/AMO/61905 |
|---|---|
| FullText URL | 75_2_225.pdf |
| Author | Xue, Haowei| Furumatsu, Takayuki| Okazaki, Yuki | Hiranaka, Takaaki| Kintaka, Keisuke | Zhang, Ximing| Yoshida, Aki| Ozaki, Toshifumi| |
| Abstract | A 65-year-old man presented with a left medial meniscus (MM) posterior root tear (PRT). Unicompartmental knee arthroplasty was performed 12 months after transtibial pullout repair of the MMPRT. Repaired MM posterior root tissue was subjected to histological analysis. Immunostaining and picrosirius red staining showed sufficient deposition of type I collagen, and hematoxylin-eosin staining using a polarized microscope showed well-aligned fiber orientation in the repaired tissue. The repaired posterior root (post-transtibial pullout repair) showed mature and well-aligned ligament-like tissue. Preserving the MM posterior root remnant to mimic the original posterior root tissue might be useful when performing pullout repair. |
| Keywords | medial meniscus posterior root tear unicompartmental knee arthroplasty histological analysis case report |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 225 |
| End Page | 230 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953430 |
| NAID | 120007029882 |
| JaLCDOI | 10.18926/AMO/61904 |
|---|---|
| FullText URL | 75_2_219.pdf |
| Author | Sugiura, Hiroyuki| Nishimori, Hisakazu| Matsuoka, Hirofumi| Nakamura, Keiichiro| Fujii, Keiko| Fujii, Nobuharu | Matsuoka, Ken-ichi | Maeda, Yoshinobu| |
| Abstract | Acute promyelocytic leukemia (APL) is a hematological emergency that requires urgent intervention because of the high incidence of early hemorrhagic death. When patients with APL experience a synchronous solid organ tumor, the tumor’s treatment must also be done properly. Differentiation-inducing therapy using arsenic trioxide (ATO) has less hematological toxicity compared to cytotoxic chemotherapy and might be preferable for untreated APL patients with a synchronous solid organ tumor. Here we describe the first successful case of untreated APL and synchronous endometrial cancer (in an adult Japanese woman) treated with ATO consolidation therapy and the subsequent surgery and chemotherapy for endometrial cancer. |
| Keywords | acute promyelocytic leukemia endometrial cancer arsenic trioxide synchronous multiple primary malignant tumor chemotherapy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 224 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953429 |
| NAID | 120007029883 |
| JaLCDOI | 10.18926/AMO/61902 |
|---|---|
| FullText URL | 75_2_205.pdf |
| Author | Hoshijima, Mitsuhiro| Kawanabe, Noriaki| Iida, Seiji| Yamashiro, Takashi| Kamioka, Hiroshi| |
| Abstract | We herein report the case of a 19-year-old female with a transverse discrepancy, skeletal Class II malocclusion, severe crowding with concerns of classic-type Ehlers-Danlos syndrome (EDS), aesthetics problems and functional problems. The main characteristics of classic EDS are loose-jointedness and fragile, easily bruised skin that heals with peculiar “cigarette-paper” scars. The anteroposterior and transverse skeletal discrepancies can generally be resolved by maxilla repositioning and mandibular advancement surgery following pre-surgical orthodontic treatment. However, this patient was treated with orthodontic camouflage but not orthognathic surgery because of the risks of skin bruising, poor healing and a temporomandibular disorder. A satisfactory dental appearance and occlusion were achieved after camouflage treatment with orthodontic anchor screws and the use of Class II elastics, including the preservation of the stomatognathic functions. Acceptable occlusion and dentition were maintained after a two-year retention period. This treatment strategy of orthodontic camouflage using temporary anchorage, such as anchor screws and Class II elastics, may be a viable treatment option for skeletal malocclusion patients with EDS. |
| Keywords | asymmetry Class II camouflage orthodontic anchor screw Ehlers-Danlos syndrome |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 205 |
| End Page | 212 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953427 |
| NAID | 120007029885 |
| JaLCDOI | 10.18926/AMO/61897 |
|---|---|
| FullText URL | 75_2_187.pdf |
| Author | Fujiwara, Yuta| Sasaki, Tomoaki| Muto, Yuki| Hirano, Masaki| Kamizaki, Ryo| Murakami, Kaito| Miura, Naoya| Fujibuchi, Yutaka| Ohmukai, Nayu| Ueda, Nao | Sugimoto, Kouhei | Ota, Kazuhiro| Kamihoriuchi, Yoshiki| Sasaki, Tomoko| Kaneshige, Souichirou| |
| Abstract | The aim of this study is to evaluate how metallic artifacts in the lumbar spine can affect images obtained from magnetic resonance (MR) sequences. We performed a phantom experiment by scanning an agar containing an orthopedic metallic implant using 64-channel multidetector row computed tomography (CT) and a 3-tesla MR unit. We compared the reproducibility in each measurement, enlargement or reduction ratio of the CT and MR measurements, and signal deviation in each voxel from the control. The reproducibility on CT and multiacquisition variable-resonance image combination selective (MAVRIC SL) was good, but that on the other MR sequences showed either fixed bias or proportional bias. The reduction ratios of the distance between the nails were significantly smaller in MAVRIC SL than in the other MR sequences after CT measurements (p<0.001, respectively). MAVRIC SL was able to reduce the metallic artifact, permitting observation of the tissue surrounding the metal with good reproducibility. |
| Keywords | metallic artifact reduction implant MAVRIC SL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 187 |
| End Page | 197 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953425 |
| NAID | 120007029889 |
| JaLCDOI | 10.18926/AMO/61895 |
|---|---|
| FullText URL | 75_2_177.pdf |
| Author | Inoue, Madoka| Noda, Tomoyuki| Uehara, Takenori| Tetsunaga, Tomonori| Yamada, Kazuki| Saito, Taichi| Shimamura, Yasunori| Yamakawa, Yasuaki| Ozaki, Toshifumi| |
| Abstract | This retrospective study sought to elucidate the incidence rates of roof impaction (RI) and marginal impaction (MI) and radiological and clinical outcomes of open reduction and internal fixation (ORIF) for RI and MI in geriatric acetabular fractures. The cases of 68 patients aged ≥ 65 years (mean 71 years) treated with ORIF were analyzed. MI was present in 12 fractures (67%) and an RI of the weight-bearing surface was present in 24 (46%) of the potential fracture types. Regarding the reduction quality, 54% of the reductions were graded as anatomical, 37% as imperfect, and 9% as poor. In the clinical evaluations of the 45 patients who had > 1-year follow-up (follow-up rate: 66.2%), 18% were graded as excellent, 53% as good, 16% as fair, and 13% as poor. An anatomic reduction was strongly associated with good or excellent clinical and radiological outcomes. CT was superior to radiographs for detecting the residual displacement postoperatively. Postoperative deep infection occurred in four patients. Three patients (6.7%) underwent a total hip arthroplasty conversion due to secondary osteoarthritis of the hip. We recommend ORIF as the preferred surgical treatment option for displaced acetabular fractures in elderly patients. |
| Keywords | acetabular fracture osteosynthesis marginal impaction roof impaction elderly patient |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 177 |
| End Page | 185 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953423 |
| NAID | 120007029891 |
| JaLCDOI | 10.18926/AMO/61881 |
|---|---|
| FullText URL | 75_2_147.pdf |
| Author | Xue, Haowei | Furumatsu, Takayuki| Okazaki, Yuki | Hiranaka, Takaaki | Kintaka, Keisuke | Fujii, Masataka | Zhang, Ximing| Ozaki, Toshifumi| |
| Abstract | Medial meniscus posterior root tears (MMPRTs) have recently attracted considerable interest in orthopedics. To date, no in vivo human study has investigated suture translation changes in repaired MMPRTs with different degrees of knee flexion. This study examined suture translation at various degrees of knee flexion in 30 patients undergoing medial meniscus posterior root repair using the modified Mason-Allen suture technique between August 2016 and September 2017. Intraoperatively, sutures were provisionally fixed to an isometric positioner at the tibial site of the desired meniscal attachment, and the suture translation was measured at 0°, 30°, 60°, and 90° of knee flexion. The results showed significant increases in mean suture translation at the knee flexion positions from 0° to 30°, 30° to 60°, and 60° to 90° (p<0.01 for all). Our findings indicate that surgeons should carefully assess the degree of knee flexion at the moment when the meniscus is refixed by surgical sutures. |
| Keywords | medial meniscus posterior root tear suture translation knee flexion arthroscopic repair |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 147 |
| End Page | 152 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953421 |
| NAID | 120007029902 |
| JaLCDOI | 10.18926/AMO/61880 |
|---|---|
| FullText URL | 75_2_139.pdf |
| Author | Hamada, Kentaro| Kuroda, Masahiro| Yoshimura, Yuuki | Khasawneh, Abdullah| Barham, Majd| Tekiki, Nouha| Sugianto, Irfan| Bamgbose, Babatunde O.| Konishi, Kohei| Sugimoto, Kohei| Ishizaka, Hinata| Kurozumi, Akira| Matsushita, Toshi | Ohno, Seiichiro| Kanazawa, Susumu| Asaumi, Junichi| |
| Abstract | Diffusion-weighted imaging may be used to obtain the apparent diffusion coefficient (ADC), which aids the diagnosis of cerebral infarction and tumors. An ADC reflects elements of free diffusion. Diffusion kurtosis imaging (DKI) has attracted attention as a restricted diffusion imaging technique. The ADC subtraction method (ASM) was developed to visualize restricted diffusion with high resolution by using two ADC maps taken with different diffusion times. We conducted the present study to provide a bridge between the reported basic ASM research and clinical research. We developed new imaging software for clinical use and evaluated its performance herein. This software performs the imaging process automatically and continuously at the pixel level, using ImageJ software. The new software uses a macro or a plugin which is compatible with various operating systems via a Java Virtual Machine. We tested the new imaging software’s performance by using a Jurkat cell bio-phantom, and the statistical evaluation of the performance clarified that the ASM values of 99.98% of the pixels in the bio-phantom and physiological saline were calculated accurately (p<0.001). The new software may serve as a useful tool for future clinical applications and restricted diffusion imaging research. |
| Keywords | apparent diffusion coefficient ADC subtraction method restricted diffusion ImageJ plugin |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 139 |
| End Page | 145 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953420 |
| NAID | 120007029903 |
| JaLCDOI | 10.18926/AMO/61879 |
|---|---|
| FullText URL | 75_2_133.pdf |
| Author | Hashida, Shinsuke| Tanaka, Norimitsu| Takahashi, Yuta| Onoda, Yuji| Colvin, Hugh Shunsuke| Ohashi, Ryuichiro| Okamoto, Kunio | |
| Abstract | As the nanoparticle albumin-bound paclitaxel (nab-PTX) is free of ethanol and premedication, the duration of administration is shorter and patients can drive themselves to and from the hospital. In the 2018 Japanese gastric cancer treatment guidelines, ramucirumab (RAM) plus weekly nab-PTX is conditionally recommended for previously treated patients with advanced gastric cancer. Here, we retrospectively analysed the efficacy and safety of RAM+nab-PTX for such patients in community hospitals. From January 2018 to December 2019, 43 patients with metastatic and recurrent gastric cancer received RAM+nab-PTX treatment. Six patients (13.9%) were older than 80 years and 9 patients (20.9%) showed ECOG-PS 2. Progression-free survival (PFS), overall survival (OS), overall response rate (ORR), disease control rate (DCR), and adverse events (AEs) were reviewed retrospectively. Median PFS was 114 days (95% confidence interval [CI]: 84-190) and median OS was 297 days (95% CI: 180-398). ORR and DCR were 32.4% and 72.2%, respectively. The incidence rates of ≥grade 3 neutropenia and febrile neutropenia were 53.5% and 2.3%, respectively. No treatment-related deaths occurred. RAM plus nab-PTX combination therapy demonstrated manageable toxicity even patients who were elderly or had an ECOG-PS 2. This treatment is useful in community hospital settings. |
| Keywords | gastric cancer ramucirumab nab-paclitaxel |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 133 |
| End Page | 138 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953419 |
| NAID | 120007029904 |
