葡萄糖利尿作用ノ機轉ニ就テ

The author made various experiments on the action of glucose as a diuretic and obtained the following results, 1) The number of glomeruli with blood circulation of a frog increases 2.5 times after the intravenous injection of 0.2cc of 25% glucose solution. 2) In frog the injection of 0.2cc of 3.75% NaCl solution (isotonic with 25% glucose solution) increases the number of glomeruli with blood circulation about twice as before injection. 3) The urine secretion of a rabbit increases about 3 times or nlore in 1-2 minutes after the injection of 3cc of 20% glucose solution. 4) The urine secretion of the dog increases after the injection of 10-15cc of 20% glucose solution. The osmotie pressure of the blood rises after the injection for a while. Conceming the osmotic pressure of blood same thing will be observed also on rabbits. 5) Blood vessels of the lower limbs of the toad widen a little with perfusion of 0.6% Ringer, s solution containing 0.38% glucose. 6) The rate of flow of blood through the kidney of rabbit does not increase by the injection of glucose. 7) The diuretic action of gluco8e is accompanied by a marked increase of the intake of oxygen by kidney. When KGN solution is injected previously the hrine secretion and also the oxygen consumption in the kidney do not increase by the injection of glucose solution. From these data could be sammalise that the diuretic action of hypertonic glucose solution depends on not only increased blood irrigation of kidney or hydraemia following increased osmotic pressure of blood but also a enhancement of secreting activity of kidney-cells take a great part.