| ID | 64043 |
| JaLCDOI | |
| FullText URL | |
| Author |
Teraishi, Fuminori
Department of Surgery, Fukuyama Daiichi Hospital
Jikuhara, Atsushi
Department of Surgery, Fukuyama Daiichi Hospital
Ogawa, Ryunosuke
Department of Surgery, Fukuyama Daiichi Hospital
Fujiwara, Toshiyoshi
Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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| Abstract | An 84-year-old female underwent open right hemicolectomy with D3 lymph node dissection for cecal cancer, pathologically identified as pT4aN2M0 Stage IIIc and BRAF mutation-positive. Due to early recurrence of abdominal wall and right lateral lymph nodes, the patient was treated with FOLFOXIRI+Bevacizumab. Imaging after 5 courses of chemotherapy found tumor shrinkage and no new metastases. The patient did not tolerate chemotherapy well, and tumor resection was performed. Microsatellite instability (MSI) testing using multiplex polymerase chain reaction (PCR) fragment analysis revealed MSI-high status. The patient is currently recurrence-free without chemotherapy at 1 year postoperatively. BRAF-mutated colorectal cancer has a poor prognosis, and may require resection of the metastatic or recurrent tumor after comprehensive evaluation.
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| Keywords | BRAF V600E mutation
cecal cancer, MSI-high
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| Amo Type | Case Report
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| Publication Title |
Acta Medica Okayama
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| Published Date | 2022-10
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| Volume | volume76
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| Issue | issue5
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| Publisher | Okayama University Medical School
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| Start Page | 605
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| End Page | 608
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| ISSN | 0386-300X
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| NCID | AA00508441
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| Content Type |
Journal Article
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| language |
English
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| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School
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| File Version | publisher
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| Refereed |
True
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| PubMed ID | |
| Web of Science KeyUT |
