result 348 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sukegawa, Shintaro| Kanno, Takahiro| Yamamoto, Norio| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| Furuki, Yoshihiko| |
| Keywords | mandibular condylar fracture unsintered hydroxyapatite poly-l-lactide composite plate bioactive resorbable plate biomechanical loading evaluation fracture fixation |
| Published Date | 2019-05-13 |
| Publication Title | Materials |
| Volume | volume12 |
| Issue | issue9 |
| Publisher | MDPI |
| Start Page | 1557 |
| ISSN | 1996-1944 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31085981 |
| DOI | 10.3390/ma12091557 |
| Web of Science KeyUT | 000469757500198 |
| Related Url | isVersionOf https://doi.org/10.3390/ma12091557 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakano, Masahito| Mukaihara, Takafumi| |
| Keywords | Ralstonia solanacearum type III effector jasmonic acid salicylic acid Nicotiana plants |
| Published Date | 2019-11-28 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume20 |
| Issue | issue23 |
| Publisher | MDPI |
| Start Page | 5992 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31795135 |
| DOI | 10.3390/ijms20235992 |
| Web of Science KeyUT | 000504428300174 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms20235992 |
| FullText URL | NCN7_5_288.pdf Fig.pdf |
|---|---|
| Author | Nakano, Yumiko| Tsunoda, Keiichiro| Yamashita, Toru| Mitsui, Jun| Sato, Kota| Takemoto, Mami| Hishikawa, Nozomi| Ohta, Yasuyuki| Toda, Tatsushi| Tsuji, Shoji| Abe, Koji| |
| Keywords | anti-cholinesterase drug the CHRNE gene congenital myasthenic syndrome late presentation mimicking seronegative myasthenia gravis |
| Note | "This is the peer reviewed version of the following article: Yumiko Nakano et. al. Late presented congenital myasthenic syndrome with novel compound heterozygous CHRNE mutations mimicking seronegative myasthenia gravis. Neurology and Clinical Neuroscience (2019) 7(5) 288-290, which has been published in final form at https://doi.org/10.1111/ncn3.12317. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."| |
| Published Date | 2019-06-29 |
| Publication Title | Neurology and Clinical Neuroscience |
| Volume | volume7 |
| Issue | issue5 |
| Publisher | Wiley |
| Start Page | 288 |
| End Page | 290 |
| ISSN | 2049-4173 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1111/ncn3.12317 |
| Web of Science KeyUT | 000476042100001 |
| Related Url | isVersionOf https://doi.org/10.1111/ncn3.12317 |
| FullText URL | JNR97_5_607.pdf Fig.pdf Fig_sup.pdf Table.pdf |
|---|---|
| Author | Ohta, Yasuyuki| Nomura, Emi| Shang, Jingwei| Feng, Tian| Huang, Yong| Liu, Xia| Shi, Xiaowen| Nakano, Yumiko| Hishikawa, Nozomi| Sato, Kota| Takemoto, Mami| Yamashita, Toru| Abe, Koji| |
| Keywords | ALS SOD1 edaravone in vivo imaging nrf2 oxidative stress |
| Published Date | 2018-12-19 |
| Publication Title | Journal of Neuroscience Research |
| Volume | volume97 |
| Issue | issue5 |
| Publisher | Wiley |
| Start Page | 607 |
| End Page | 609 |
| ISSN | 0360-4012 |
| NCID | AA00703378 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 30565312 |
| DOI | 10.1002/jnr.24368 |
| Web of Science KeyUT | 000461891200008 |
| Related Url | isVersionOf https://doi.org/10.1002/jnr.24368 |
| FullText URL | SR9_1_10956.pdf |
|---|---|
| Author | Yamashita, Toru| Shang, Jingwei| Nakano, Yumiko| Morihara, Ryuta| Sato, Kota| Takemoto, Mami| Hishikawa, Nozomi| Ohta, Yasuyuki| Abe, Koji| |
| Published Date | 2019-07-29 |
| Publication Title | Scientific Reports |
| Volume | volume9 |
| Issue | issue1 |
| Publisher | NPG |
| Start Page | 10956 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2019 |
| File Version | publisher |
| PubMed ID | 31358888 |
| DOI | 10.1038/s41598-019-47482-0 |
| Web of Science KeyUT | 000477701800059 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-47482-0 |
| FullText URL | JAD68_4_1667.pdf Fig.pdf |
|---|---|
| Author | Shi, Xiaowen | Liu, Xia| Shang, Jingwei| Morihara, Ryuta| Nakano, Yumiko| Feng, Tian| Huang, Yong| Sato, Kota| Takemoto, Mami| Hishikawa, Nozomi| Yamashita, Toru| Abe, Koji| |
| Keywords | AHSG APP23 mice ITIH4 alzheimer’s disease hypoperfusion inflammation |
| Published Date | 2019-04-23 |
| Publication Title | Journal of Alzheimer's Disease |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | IOS Press |
| Start Page | 1667 |
| End Page | 1675 |
| ISSN | 1387-2877 |
| NCID | AA11545428 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 30958362 |
| DOI | 10.3233/JAD-181218 |
| Web of Science KeyUT | 000465612500029 |
| Related Url | isVersionOf https://doi.org/10.3233/JAD-181218 |
| FullText URL | JAD71_1_327.pdf |
|---|---|
| Author | Feng, Tian| Yamashita, Toru| Shang, Jingwei| Shi, Xiaowen| Nakano, Yumiko| Morihara, Ryuta| Tsunoda, Keiichiro| Nomura, Emi| Sasaki, Ryo| Tadokoro, Koh| Matsumoto, Namiko| Hishikawa, Nozomi| Ohta, Yasuyuki| Abe, Koji| |
| Keywords | Alzheimer’s disease chronic cerebral hypoperfusion edaravone neural oxidative stress neuroinflammation neuronal loss |
| Note | The final publication is available at IOS Press through https://doi.org/10.3233/JAD-190369| |
| Published Date | 2019-09-03 |
| Publication Title | Journal of Alzheimer's Disease |
| Volume | volume71 |
| Issue | issue1 |
| Publisher | IOS Press |
| Start Page | 327 |
| End Page | 339 |
| ISSN | 1387-2877 |
| NCID | AA11545428 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31403949 |
| DOI | 10.3233/JAD-190369 |
| Web of Science KeyUT | 000484216500026 |
| Related Url | isVersionOf https://doi.org/10.3233/JAD-190369 |
| FullText URL | JBMRA_107_5_1021.pdf |
|---|---|
| Author | Kunitomi, Yosuke| Hara, Emilio Satoshi| Okada, Masahiro| Nagaoka, Noriyuki| Kuboki, Takuo| Nakano, Takayoshi| Kamioka, Hiroshi| Matsumoto, Takuya| |
| Keywords | apatite bioinspired mineralization bone hydrogel matrix vesicle nanofragments |
| Published Date | 2019-01-24 |
| Publication Title | Journal of Biomedical Materials Research Part A |
| Volume | volume107 |
| Issue | issue5 |
| Publisher | Wiley |
| Start Page | 1021 |
| End Page | 1030 |
| ISSN | 1549-3296 |
| NCID | AA11881516 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. |
| File Version | publisher |
| PubMed ID | 30675987 |
| DOI | 10.1002/jbm.a.36618 |
| Web of Science KeyUT | 000462623800012 |
| Related Url | isVersionOf https://doi.org/10.1002/jbm.a.36618 |
| FullText URL | J_MedChem_62_19_8809.pdf si_001.pdf si_002.csv |
|---|---|
| Author | Yamada, Shoya| Kawasaki, Mayu| Fujihara, Michiko| Watanabe, Masaki| Takamura, Yuta| Takioku, Maho| Nishioka, Hiromi| Takeuchi, Yasuo| Makishima, Makoto| Motoyama, Tomoharu| Ito, Sohei| Tokiwa, Hiroaki| Nakano, Shogo| Kakuta, Hiroki| |
| Note | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jmedchem.9b00995.| |
| Published Date | 2019-09-04 |
| Publication Title | Journal of Medicinal Chemistry |
| Volume | volume62 |
| Issue | issue19 |
| Publisher | American Chemical Society |
| Start Page | 8809 |
| End Page | 8818 |
| ISSN | 00222623 |
| NCID | AA00702411 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 American Chemical Society |
| File Version | author |
| PubMed ID | 31483660 |
| DOI | 10.1021/acs.jmedchem.9b00995 |
| Web of Science KeyUT | 000490355000010 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.jmedchem.9b00995 |
| FullText URL | IntJMolSci_20_8_1973.pdf |
|---|---|
| Author | Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Yoshida, Saori| Maeda, Hatsuhiko| Kawakami, Toshiyuki| Nagatsuka, Hitoshi| |
| Keywords | cell differentiation epithelial-mesenchymal interaction immunohistochemistry malignant transformation notch signaling odontogenic tumor pleomorphic adenoma |
| Published Date | 2019-04-23 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume20 |
| Issue | issue8 |
| Publisher | MDPI |
| Start Page | 1973 |
| ISSN | 14220067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31018488 |
| DOI | 10.3390/ijms20081973 |
| Web of Science KeyUT | 000467648700171 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms20081973 |
| JaLCDOI | 10.18926/AMO/57374 |
|---|---|
| FullText URL | 73_5_433.pdf |
| Author | Tamada, Shoko| Mitsui, Takashi| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eguchi, Takeshi| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi| |
| Abstract | An association between preeclampsia and (pro)renin was recently reported. Intracellular signaling of the (pro) renin receptor [(P)RR] increases the expressions of TGF-β and PAI-1. In this study we sought to clarify the involvement of (pro)renin in the pathogenesis of preeclampsia via the intracellular signaling of (P)RR on preeclampsia placentas. Activated (pro)renin plasma concentrations were compared between pregnant women with (n=15) and without (n=28) preeclampsia. The placentas were immunohistochemically evaluated with anti-HIF-1α and anti-(P)RR antibodies. HTR-8/SVneo cells were cultured under hypoxic conditions and treated with human recombinant (pro)renin. The mRNA expressions of HIF-1α, (P)RR, PAI-1, TGF-β, and ET-1 were also examined by real-time RCR. The activated (pro)renin plasma concentration was significantly higher in the third vs. the second trimester in the preeclampsia patients. HIF-1α and (P)RR expressions were significantly increased in the preeclampsia placentas. The mRNA expressions of PAI-1, TGF-β, and ET-1 were significantly increased in the experiments using recombinant (pro)renin vs. hypoxic conditions. (P)RR expression in preeclampsia placentas is increased by persistent hypoxia through the second and third trimesters, and PAI-1, TGF-β, and ET-1 production is increased via (P)RR. Our results suggest that ET-1 production via the intracellular signaling of (P)RR is important in the pathogenesis of preeclampsia. |
| Keywords | preeclampsia (pro)renin (pro)renin receptor endothelin-1 HTR-8/SVneo |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 433 |
| End Page | 440 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649370 |
| Web of Science KeyUT | 000491886600009 |
| JaLCDOI | 10.18926/AMO/57370 |
|---|---|
| FullText URL | 73_5_403.pdf |
| Author | Ando, Akemi| Mitsuhashi, Toshiharu| Honda, Mitsugi| Hanayama, Yoshihisa| Hasegawa, Kou| Obika, Mikako| Kataoka, Hitomi| Otsuka, Fumio| |
| Abstract | Osteoporosis increases the risk of bone fractures. It is diagnosed based on an individual’s bone mineral density (BMD) or a fracture without trauma. BMD is usually measured by the dual energy X-ray absorptiometry (DXA) method. Here we investigated factors for the earliest possible prediction of decreased BMD by examining the relationships between patients’ BMD values and changes in the patients’ physical and laboratory values. We retrospectively reviewed the medical records of 149 patients who visited our department in 2014-2015 for a variety of reasons and underwent an area BMD examination by DXA. We analyzed the relationships between decreasing BMD and the patients’ gender, age, body mass index (BMI), medical background, hemoglobin, electrolytes, and thyroid function. Thirty-nine of the patients were diagnosed with osteoporosis based on their T-scores. An adjusted analysis showed that female gender, aging, and increased serum calcium level were significantly related to decreasing femoral BMD, whereas high BMI was associated with an increase in femoral BMD. Collectively the results indicate that for the early detection of low BMD, it is important for general-practice physicians to consider conducting a BMD checkup when treating female and elderly patients with a low BMI and/or elevated serum calcium level. |
| Keywords | bone mineral density (BMD) body mass index (BMI) female gender hypercalcemia osteoporosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 403 |
| End Page | 411 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649366 |
| Web of Science KeyUT | 000491886600005 |
| JaLCDOI | 10.18926/AMO/56937 |
|---|---|
| FullText URL | 73_4_349.pdf |
| Author | Isozaki, Hiroshi| Yamamoto, Yasuhisa| Murakami, Shigeki| Matsumoto, Sasau| Takama, Takehiro| |
| Abstract | To clarify the surgical outcomes of breast cancer patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) by core needle biopsy (CNB) (abbreviated as CNBDCIS), we retrospectively analyzed the cases of 131 patients with CNBDCIS who underwent surgery at Oomoto Hospital (32 total mastectomies, 99 conservative mastectomies). Our analysis of underestimation and predictors of invasive breast cancer of CNBDCIS revealed that the underestimation rate of CNBDCIS was 40.5% (53/131). A logistic regression analysis revealed that palpable tumors (yes to no, odds ratio [OR] 3.25), mammography (MMG) category group (category 4 or 5 to categories 1 , 2, or 3, OR 4.69) and MMG microcalcifications (no to yes, OR 0.24) were significant predictive factors for CNBDCIS invasion. In our analysis of the predictors of positive margins during CNBDCIS surgery, 36 (27.5%) of the 131 patients had positive margins after postoperative pathological examination. A logistic regression analysis revealed that the operative procedure (conservative surgery to total mastectomy, OR 21.4) and MMG microcalcifications (yes to no, OR 3.35) were significant factors related to positive margins during CNBDCIS surgery. Thus, MMG microcalcifications are a negative predictor of upgrading of CNBDCIS and a positive predictor of positive surgical margins for CNBDCIS. |
| Keywords | ductal carcinoma in situ core needle biopsy underestimation positive margins microcalcifications on mammography |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 349 |
| End Page | 356 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439958 |
| JaLCDOI | 10.18926/AMO/56934 |
|---|---|
| FullText URL | 73_4_325.pdf |
| Author | Ueno, Tsuyoshi| Maki, Yuho| Sugimoto, Ryujiro| Suehisa, Hiroshi| Yamashita, Motohiro| Harada, Daijiro| Kozuki, Toshiyuki| Nogami, Naoyuki| |
| Abstract | Therapeutic approaches to bronchopleural fistula (BPF) closure after lung resection are surgical or endoscopic interventions. We evaluated therapeutic outcomes to determine the optimal approach. We reviewed 15 patients who had developed BPF after lung resection for thoracic malignant diseases at our institution in the 10 years since 2008. The patients were 11 men and 4 women (mean age 68 years). We performed one pneumonectomy, 6 lobectomies, 7 segmentectomies, and one partial resection for malignant diseases. The median interval from lung resection to the BPF diagnosis was 46 days. The BPF-associated mortality rate was 26.7% (4/15). The rate of successful BPF closure was 66.6% (10/15). The endoscopic and surgical intervention success rates were 14.2% (1/7) and 69.2% (9/13), respectively (p<0.01). Of 5 patients who had failed BPF treatments, 4 died, and one transferred out without BPF closure. The therapeutic outcomes were related to preoperative comorbidities, performance status at the BPF diagnosis, time intervals from lung resection to BPF diagnosis, and presence of active pneumonia. The difference between endoscopic and surgical outcomes was nonsignificant, although the surgical intervention success rate was somewhat higher. The selection of endoscopic or surgical intervention for BPF does not significantly affect therapeutic outcomes. |
| Keywords | bronchopleural fistula endoscopic intervention surgical intervention |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 325 |
| End Page | 331 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439955 |
| JaLCDOI | 10.18926/AMO/56930 |
|---|---|
| FullText URL | 73_4_285.pdf |
| Author | Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| Abstract | Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion. |
| Keywords | glioma cytoskeletons invasion microtubules |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439951 |
| JaLCDOI | 10.18926/AMO/56868 |
|---|---|
| FullText URL | 73_3_247.pdf |
| Author | Yoshio, Kotaro| Wakita, Akihisa| Mitsuhashi, Toshiharu| Kitayama, Takahiro| Hisazumi, Kento| Inoue, Daisaku| Tajiri, Nobuhisa| Shiode, Tsuyoki| Akaki, Shiro| Kanazawa, Susumu| |
| Abstract | We investigated the feasibility of simultaneous integrated boost (SIB) volumetric modulated arc therapy (VMAT) using elective nodal irradiation (ENI) for middle or lower esophageal cancer and compared it with three-dimensional conformal radiotherapy (3D-CRT). The study included 15 patients. The prescribed doses included a standard dose (50.4 Gy) and a high dose (60 Gy) for the planning target volume (PTV) of the involved lesions. The objective of the whole lung volume receiving ≥ 20 Gy (V20Gy) was < 30%, and the mean lung dose (MLD) was < 20 Gy. The volumes of the lung receiving 5 Gy (V5Gy) and the heart receiving 30-50 Gy (V30-50Gy) were kept as low as reasonably achievable. As a result, SIB-VMAT showed superior dose conformity for the PTV (p<0.001). Although the lung V5Gy was significantly increased (p<0.001), the V20Gy and MLD showed no significant increase. The heart V30-50Gy showed a > 20% reduction in the mean against 3D-CRTs. Our results demonstrate the feasibility of SIB-VMAT for the treatment of middle or lower esophageal cancer with ENI. Although attention should be paid to the low-dose area of the lungs, SIB-VMAT would be a promising treatment option with improved outcomes for esophageal cancer. |
| Keywords | esophageal cancer middle and lower thoracic volumetric modulated arc therapy, 3D-CRT elective nodal irradiation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 247 |
| End Page | 257 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235973 |
| JaLCDOI | 10.18926/AMO/56649 |
|---|---|
| FullText URL | 73_2_135.pdf |
| Author | Maeba, Takahiro| Yonezawa, Tomoko| Ono, Mitsuaki| Tomono, Yasuko| Heljasvaara, Ritva| Pihlajaniemi, Taina| Inagawa, Kiichi| Oohashi, Toshitaka| |
| Abstract | The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was detected at days 3 and 6 post-wounding. The ultrastructure of epidermal BM was discontinuous at day 3, whereas on day 6 a continuous BM was observed in the region proximal to the wound edge. Immunohistochemistry demonstrated that collagen XVIII was deposited in the BM zone beneath newly forming epidermis in day 3 and 6 wounds. Laminin-332, known to be the earliest BM component appearing in wounds, was colocalized with collagen XVIII in the epidermal BM zone at days 3 and 6. The deposition of α1(IV) collagen and nidogen-1 in the epidermal BM zone occurred later than that of collagen XVIII. We also observed the short isoform of collagen XVIII in the epidermal BM zone at day 3 post-wounding. Collectively, our results suggested that collagen XVIII plays a role in the formation of the dermal-epidermal junction during re-epithelialization, and that it is the short isoform that is involved in the early phase of re-epithelialization. |
| Keywords | collagen XVIII basement membrane wound healing re-epithelialization skin |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-04 |
| Volume | volume73 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 135 |
| End Page | 146 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31015748 |
| JaLCDOI | 10.18926/56521 |
|---|---|
| Title Alternative | Intercultural Education for Japanese Students Using Revised Muslim Culture Assimilators |
| FullText URL | scs_018_053_066.pdf |
| Author | Nakano, Sachiko| Tanaka, Tomoko| |
| Publication Title | Studies in Cultural Symbiotics |
| Published Date | 2019-03-15 |
| Volume | volume18 |
| Start Page | 53 |
| End Page | 66 |
| ISSN | 1880-9162 |
| language | Japanese |
| Copyright Holders | Copyright © 2019 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120006583681 |
| JaLCDOI | 10.18926/AMO/56464 |
|---|---|
| FullText URL | 73_1_85.pdf |
| Author | Abe, Yoshiyuki| Fujibayashi, Kazutoshi| Nishizaki, Yuji| Yanagisawa, Naotake| Nojiri, Shuko| Nakano, Soichiro| Tada, Kurisu| Yamaji, Ken| Tamura, Naoto| |
| Abstract | Pneumocystis pneumonia (PCP) due to Pneumocystis jirovecii infection is the leading cause of fatal opportunistic infections in immunocompromised patients. We will determine whether a daily sulfamethoxazole-trimethoprim (SMX/TMP) dose of 200/40 mg was non-inferior to 400/80 mg for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. This is a randomized, open-label, multicenter controlled trial. The primary outcome is the rate of PCP prevention at 52 weeks. The secondary outcome is the discontinuation rate of SMX/TMP. The trial will evaluate the optimal dose of SMX/TMP for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. |
| Keywords | pneumocystis pneumonia prophylaxis systemic rheumatic disease sulfamethoxazole-trimethoprim conventional-dose versus half-dose |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 85 |
| End Page | 89 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820060 |
| FullText URL | PhysRevB_97_094525.pdf |
|---|---|
| Author | Terashima, K.| Paris, E.| Simonelli, L.| Salas-Colera, E.| Puri, A.| Wakita, T.| Yamada, Y.| Nakano, S.| Idei, H.| Kudo, K.| Nohara, M.| Muraoka, Y.| Mizokawa, T.| Yokoya, T.| Saini, N. L.| |
| Note | This is an article published by American Physical Society| |
| Published Date | 2018-09-28 |
| Publication Title | Physical Review B |
| Volume | volume98 |
| Issue | issue9 |
| Publisher | American Physical Society |
| Start Page | 094525 |
| ISSN | 24699950 |
| NCID | AA11187113 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| DOI | 10.1103/PhysRevB.98.094525 |
| Web of Science KeyUT | 000446178800008 |
| Related Url | isVersionOf https://doi.org/10.1103/PhysRevB.98.094525 |
