result 2543 件
| Author | Hara Akira| Yamaguchi Tomohisa| Ichimura Takumi| Takahama Tetsuyuki| |
|---|---|
| Published Date | 2008-12 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Mera Kazuya| Ichimura Takumi| |
|---|---|
| Published Date | 2008-12 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| JaLCDOI | 10.18926/14788 |
|---|---|
| Title Alternative | 肺気腫と喘息のHRCT上のlow attenuation are（LAA）の性質の差。喫煙との関連を含めて |
| FullText URL | 74_035_041.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro| |
| Abstract | The low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) was evaluated in 20 asthmatics (10 ex-smokers and 10 never-smokers) and 10 patients with pulmonary emphysema (all ex-smokers) by ventilatory function, lung volume, DLco, and a ratio of expiratory LAA/inspiratory LAA. 1 . The % LAA of the lungs on HRCT was significantly larger in patients with pulmonary emphysema(PE) than in those with asthma, but there was not significant difference in % LAA between ex-smokers and never-smokers of asthmatics. 2. A ratio of expiratory Winspiratory LAA was significantly higher in patients with PE than in those with asthma , and the ratio was significantly higher in ex-smokers of asthmatics than in never-smokers (p<0.05). 3 . The difference in % residual volume and % DLco was significant between asthma and PE , and between ex - smokers and never-smokers of asthmatics (% RV : p<0.05, DLco : p<0.05) . 4 . The difference in the values of % FVC, % FEV(1) .O, and FEV1.0% was significant between asthma and PE, but not significant between ex-smokers and never- smokers of asthmatics. The results suggest that the difference in a ratio of expiratory W inspiratory LAA, % RV and % DLco was significant between ex - smokers and never - smokers of asthmatics , and cigarette smoking induces more irreversible changes of the lungs. |
| Keywords | low attenuation area asthma pulmonary emphysema cigarette smoking |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 35 |
| End Page | 41 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308507 |
| JaLCDOI | 10.18926/14787 |
|---|---|
| FullText URL | 74_026_034.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Iwagaki, Naofumi| Nagata, Takuya| Fujii, Makoto| Takata, Shingo| Yokoi, Tadashi| Hamada, Masanori| Tanizaki, Yoshiro| |
| Abstract | To determine the characteristics of the elderly in high - resolution computed tomography (HRCT) lung densitometry, mean lung density (MLD) and relative area of the lungs showing attenuation values less than -950 HU (RA(950)) on HRCT were evaluated in nonsmoking control subjects (n = 80) and patients with asthma (n = 80) in relation to their age and pulmonary function. MLD was significantly decreased, and RAW was significantly increased with increasing age in both asthmatics and controls. The MLD values were significantly lower in asthmatics compared with controls in subjects aged between 60 and 69 years and over age 70. RAgsov alues were significantly higher in asthmatics compared with controls in subjects aged between 50 and 59 years, between 60 and 69, and over 70. % FEV(1) and FEV(1) / FVC were significantly decreased in elderly asthmatic patients over 70 years of age compared with the values in those under 49. Percent residual volume (% RV) was significantly larger in patients over 70 years of age than in those between 50 and 59, and under 49 years. RAW was significantly larger in patients with steroid-dependent intractable asthma (SDIA) between 50 and 59 years of age, and between 60 and 69 compared with RA 950 in those without SDIA. However, RAW did not differ significantly between SDIA and non-SDIA in patients over age 70. The results suggested that in % LAA of the lungs on HRCT was significantly increased in the elderly subjects with and without asthma, and it was significantly higher in the elderly asthmatics than the elderly controls. |
| Keywords | aging (加齢) high-resolution computed tomography (高分解能CT) low attenuation area (低吸収域) mean lung density (平均CT値) pulmonary function (肺機能) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-02-01 |
| Volume | volume74 |
| Start Page | 26 |
| End Page | 34 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308286 |
| JaLCDOI | 10.18926/14766 |
|---|---|
| FullText URL | 73_044_048.pdf |
| Author | Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Yokoi, Tadashi| Takata, Shingo| Tanizaki, Yoshiro| |
| Abstract | The influence of cigarette smoke on pulmonary function, airflow, lung volume, and transfer factor in patients with asthma was examined in 40 subjects over the age of 70 years (20 ever-smokers and 20 never-smokers), and 20 patients with pulmonary emphysema over age 70 (all ex-smokers). The ventilatory parameters showing airflow limitation (% FEV(1) and FEV(1)%) were not significantly different between ever-smokers and never-smokers of elderly asthmatics. In contrast, % FEV(1) and FEV(1) % values were significantly lower in patients with pulmonary emphysema than in those with asthma with or without a history of smoking. The % RV value was significantly larger and % DLco value was significantly more decreased in ever-smokers compared with neversmokers of the elderly asthmatics. However, there were no significant differences in % RV and % DLco values between asthmatics with a history of smoking and patients with pulmonary emphysema. The results show that cigarette smoke inflluences % RV and % DLco, but not % FEV(1) and FEV(1) %, suggesting airflow limitation of large and moderate size airways. |
| Keywords | cigarette smoking FEV(1) % % RV % DLco elderly asthmatics |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 44 |
| End Page | 48 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308159 |
| JaLCDOI | 10.18926/14765 |
|---|---|
| FullText URL | 73_039_043.pdf |
| Author | Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Ashida, Kozo| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| Ochi, Koji| Fukuda, Tetsuya| Shiratori, Yasushi| |
| Abstract | 糖尿病や閉塞性動脈硬化症(ASO)の患者に合併する難治性潰瘍や壊疸の予知,予防を目的として高齢者の末梢循環の観察を行った. 下肢に冷え症,しびれ感,神経痛,歩行障害等を有し温泉療法を希望した患者21例(年齢58-78歳,平均年齢71.4歳)について,下肢の末梢循環障害の程度をレーザードプラー血流計を用いて評価した｡測定は20℃冷水負荷後30分後に,末梢皮膚血流量について測定を行った｡ レーザードプラー血流計で得られた結果は左右足趾始起部5カ所,計10カ所の平均値で表した｡7例については1年後に再測定を行った.14例についてはプロスタグランディン製剤(ベラプロスト)を投与し3ケ月後に再測定を行った｡ 1.自然経過群の7例(平均年齢73.0歳)は初回測定時の血流量は1.82±0.98であった｡2回目測定時は1.59±0.40であった｡血流量の低下傾向を認めたが有意差を認めなかった｡ 2.一方,ベラプロスト内服群の14例(平均年齢70.6歳)は初回測定時の血流量は1.27±0.35であった｡2回目測定時には1.62±0.51であった｡血流量の増加を認めた(P<0.0002)。 3.両群について,3ヶ月当たりの変化率で比較したところ自然経過群は3ヶ月当たり-1.7%の低下傾向を示した｡一方,ベラプロスト内服群は+15.4%の増加(p<0.02)を示 した｡ 4.プロスタグランディン製剤の内服中であっても加齢と共に末梢循環血流Iが低下する症例があり温泉療法を含めた集学的治療の必要性が示唆された｡ |
| Keywords | 加齢 (aging) 末梢循環 (Peripheral circulation) 動脈硬化 (arteriosclerosis) レーザードプラー血流計 (Laser-Doppler blood flowmetry) ベラプロスト (beraprost) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 39 |
| End Page | 43 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308363 |
| JaLCDOI | 10.18926/14764 |
|---|---|
| Title Alternative | lgEにmediatedされるアレルギ反応― 、肺機能、HRCT上の肺のlow attenuatjonarea (LAA)、およびLTB4,LTC4産生から見た喘息の病態に対する加齢の影響 |
| FullText URL | 73_031_038.pdf |
| Author | Mitsunobu, Fumihiro| Ashida, Kozo| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Yokoi, Tadashi| Takata, Shingo| Tanizaki, Yoshiro| |
| Abstract | The influence of aging on the pathophysiology of asthma in the elderly was examined in 40 patients (20 younger asthmatics under the age of 50 years, mean age 32.5 years and 20 elderly asthmatics over the age of 70 years, mean age 74.3 years), relating to IgE - mediated allergy, pulmonary function, low attenuation area (LAA) of the lungs on HRCT, and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leukocytes. The frequency of patients with serum IgE of more than 200 IU/ml, and the incidence of those with a positive RAST score for inhalant allergens were significantly higher in younger patients than in elderly subjects. The values of % FVC, % FEV1 and FEV 1% were significantly larger in younger patients compared with elderly subjects. The % RV was significantly larger in elderly patients than in younger patients, however, the difference in % DLco was not significant between the two age groups. The LAA of the lungs on HRCT and the ratio of expiratory LAA (exp LAA) to inspiratory LAA (ins LAA) were also significantly larger in elderly asthmatics than in younger subjects. The generation of LTB4 and LTC4 was larger in younger patients than in elderly subjects, and LTB4 generation was significantly larger in younger subjects compared with elderly subjects. These results suggest that changes in IgE-mediated allergy, airflow and lung volume accompanied with hyperinflation are often observed in elderly asthmatics. |
| Keywords | IgE-mediated allergy pulmonary function elderly asthmatics HRCT % RV |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 31 |
| End Page | 38 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308601 |
| Author | Murata, Atsuo| |
|---|---|
| Published Date | 2008/12/10 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| JaLCDOI | 10.18926/14758 |
|---|---|
| Title Alternative | 長期間喫煙による気管支唱息,肺気腫の病態的変化 |
| FullText URL | 075_074_087.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Hamada, Masanori| Iwagaki, Naofumi| Fujii, Makoto| Takata, Shingo| Tanizaki, Yoshiro| |
| Abstract | The influence of long-term cigarette smoking on the pathophysiology of chronic respiratory diseases with obstructive ventilatory dysfunction was discussed in patients with asthma and pulmonary emphysema (PE). 1. In patients with asthma, significant differences in the pathophysiology of the disease were observed between smokers and nonsmokers. A positive RAST score against inhalant allergens, bronchial hyperresponsiveness, and LTB4 generation by leucocytes were significantly more increased in smokers than in nonsmokers. The values of FEV1/FVC and OLco were significantly more decreased, and % RV was significantly more increased in smokers than in nonsmokers. 2. In comparison of asthma with PE, IgE-mediated allergy was significantly more increased in smokers with asthma than in nonsmokers with asthma and in smokers with PE. The values of % FEV1, FEVl %, and % OLco were significantly higher in nonsmokers with asthma than in smokers with PE, however, the % OLco and % RV were not significantly different between smokers with asthma and those with PE. The % LAA of the lungs on HRCT was larger in patients with PE than in smokers and nonsmokers with asthma. The results suggest that cigarette smoking influences the pathophysiology of asthma and PE. |
| Keywords | cigarette smoking (喫煙) pulmonary function (肺機能) hyperinflation (肺の過膨張) asthma (喘息) pulmonary emphysema (肺気腫) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2004-12-01 |
| Volume | volume75 |
| Start Page | 74 |
| End Page | 87 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308631 |
| JaLCDOI | 10.18926/14753 |
|---|---|
| Title Alternative | 高齢者喘息における HRCT 上の肺の low attenuation area (LAA) に及ぼす長期間喫煙の影響．肺気腫症例との比較． |
| FullText URL | 73_019_024.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| |
| Abstract | The influence of cigarette smoking on the pathophysiology in elderly patients with asthma. Forty asthmatics over the age of 70 years (20 ex-smokers and 20 never-smokers), and 20 patients with pulmonary emphysema over age 70 (all ever-smokers) were studied to determine the influence of cigarette smoke on the low attenuation area (LAA) <-950 HU (RA950) of the lungs on high resolution CT (HRCT) scans, and the ratio of expiratory LAA to inspiratory LAA of the lungs in relation to pulmonary function. The LAA value was significantly higher in patients with pulmonary emphysema compared with ever-smokers of asthmatics. The LAA ratio was significantly higher in ever-smokers than in never-smokers of asthmatics, and the ratio was less than 0.5 in all never-smokers, and the ratio was more than 0.5 in 10 of 20 ever-smokers of asthmatics and in all patients with pulmonary emphysema. The % RV (residual volume) was significaltly larger and % DLco (diffusing capacity for carbon monoxide) was significantly lower in subjects with the ratio more than 0.5 than in those with the ratio less than 0.5. These results suggest that cigarette smoke influences LAA of the lungs in relation to % RV value and % DLco value. |
| Keywords | cigarette smoking high resolution CT % RV % DLco elderly asthmatics |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 19 |
| End Page | 24 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308216 |
| Author | Iijima, Sumio| |
|---|---|
| Published Date | 2008-12 |
| Publication Title | 環境制御 |
| Volume | volume30 |
| Content Type | Journal Article |
| Author | Morimoto, Setsuo| |
|---|---|
| Published Date | 1966-05-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume78 |
| Issue | issue4-5 |
| Content Type | Journal Article |
| Author | Taguchi, Toyohiro| |
|---|---|
| Published Date | 1990-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume102 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| Author | Satoh, Shuhei| Kitagawa, Takahiro| Satoh, Nobuo| Togami, Izumi| Kimoto, Shin| Hiraki, Yoshio| Uno, Satoru| Kumon, Hiromi| Ohmori, Hiroyuki| |
|---|---|
| Published Date | 1991 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume103 |
| Issue | issue11-12 |
| Content Type | Journal Article |
| Author | Yunoki, Emiko| |
|---|---|
| Published Date | 1991 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume103 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| Author | Watanabe, Hirofumi| |
|---|---|
| Published Date | 1991 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume103 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| Author | Yoshihara, Eisuke| |
|---|---|
| Published Date | 1992 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume104 |
| Issue | issue5-6 |
| Content Type | Journal Article |
| Author | Shiote, Akihiro| |
|---|---|
| Published Date | 1992 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume104 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/14196 |
|---|---|
| FullText URL | 21_109.pdf |
| Author | Akamatsu, Nobuya| |
| Publication Title | 岡山大学大学院社会文化科学研究科紀要 |
| Published Date | 2008-11-28 |
| Volume | volume26 |
| Issue | issue1 |
| Start Page | 109 |
| End Page | 123 |
| ISSN | 1881-1671 |
| language | French |
| Copyright Holders | 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120002308566 |
| Author | Ogurusu, Kazuro| |
|---|---|
| Published Date | 1992-08 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume104 |
| Issue | issue7-8 |
| Content Type | Journal Article |
