result 47495 件
| Author | Mizuta, Eizaburo| |
|---|---|
| Published Date | 1959-11-20 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue12-1 |
| Content Type | Journal Article |
| Author | Mizuta, Eizaburo| |
|---|---|
| Published Date | 1959-11-20 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue12-1 |
| Content Type | Journal Article |
| Author | Mizuta, Eizaburo| |
|---|---|
| Published Date | 1959-11-20 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue12-1 |
| Content Type | Journal Article |
| Author | Mizuta, Eizaburo| |
|---|---|
| Published Date | 1959-11-20 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue12-1 |
| Content Type | Journal Article |
| Author | Kunihara, Kakuso| |
|---|---|
| Published Date | 1959-11-20 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue12-1 |
| Content Type | Journal Article |
| Author | Ikeda, Jushin| |
|---|---|
| Published Date | 1959-11-20 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue12-1 |
| Content Type | Journal Article |
| Author | Ikeda, Jushin| |
|---|---|
| Published Date | 1959-11-20 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue12-1 |
| Content Type | Journal Article |
| Author | Miyata, Nobuhiro| |
|---|---|
| Published Date | 1959-11-20 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue12-1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/41327 |
|---|---|
| FullText URL | 64_6_407.pdf |
| Author | Ogata, Sho| Horio, Takuya| Sugiura, Yoshiaki| Shimazaki, Hideyuki| Saito, Hiroki| Aiko, Satoshi| Nakanishi, Kuniaki| Kawai, Toshiaki| |
| Abstract | Sarcoidosis is a systemic granulomatous inflammation of unknown etiology, and seems to involve the liver parenchyma in most cases. However, sarcoidosis-associated hepatocellular carcinoma is rare. We report here a case in which a hepatocellular carcinoma occurred within the liver, which was probably involved as a result of systemic sarcoidosis. A 57-year-old Japanese man had been followed up for 2 years because of diabetic nephropathy and sarcoidosis. On admission for pneumonia, imaging studies revealed an unexpected hepatic tumor. Histology revealed a hepatocellular carcinoma accompanied by T-lymphocytic infiltration and marked granulomatous inflammation, which was surrounding some tumor nodules. The background liver parenchyma exhibited a moderate degree of fibrosis with granulomatous inflammation. The patient had no other apparent liver disease such as viral hepatitis, steatohepatitis, or primary biliary cirrhosis. Therefore, in the present case, sarcoidosis may be considered the probable background etiology for hepatocarcinogenesis. |
| Keywords | granuloma hepatocellular carcinoma lymphocytic infiltration sarcoidosis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 407 |
| End Page | 410 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173811 |
| Web of Science KeyUT | 000285664200008 |
| JaLCDOI | 10.18926/AMO/41326 |
|---|---|
| FullText URL | 64_6_399.pdf |
| Author | Chang, Chin-Hsien| Chen, Kuo-Ti| Lee, Tsong-Hai| Wang, Chao-Hung| Kuo, Yi-Wen| Chiu, Ya-Huang| Hsieh, Ching-Liang| Wu, Chang-Jer| Chang, Yen-Lin| |
| Abstract | Vascular endothelial damage has been found to be associated with thrombus formation, which is considered to be a risk factor for cardiovascular disease. A diet of natto leads to a low prevalence of cardiovascular disease. The aim of the present study was to investigate the effects of natto extract on vascular endothelia damage with exposure to laser irradiation. Endothelial damage both in vitro and in vivo was induced by irradiation of rose bengal using a DPSS green laser. Cell viability was determined by MTS assay, and the intimal thickening was verified by a histological approach. The antioxidant content of natto extract was determined for the free radical scavenging activity. Endothelial cells were injured in the presence of rose bengal irradiated in a dose-dependent manner. Natto extract exhibits high levels of antioxidant activity compared with purified natto kinase. Apoptosis of laser-injured endothelial cells was significantly reduced in the presence of natto extract. Both the natto extract and natto kinase suppressed intimal thickening in rats with endothelial injury. The present findings suggest that natto extract suppresses vessel thickening as a synergic effect attributed to its antioxidant and anti-apoptosis properties. |
| Keywords | laser irradiation natto extract thrombolysis thrombosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 399 |
| End Page | 406 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173810 |
| Web of Science KeyUT | 000285664200007 |
| JaLCDOI | 10.18926/AMO/41325 |
|---|---|
| FullText URL | 64_6_391.pdf |
| Author | Suezawa, Takanori| Ishino, Kozo| Honjo, Osami| Osaki, Satoru| Kotani, Yasuhiro| Sano, Shunji| |
| Abstract | We developed a new cardiopulmonary bypass (CPB) method to minimize myocardial damage during aortic arch reconstruction. In this method, coronary flow and heartbeat were stabilized by maintaining the aortic root pressure with an adjusted preload of the ventricle during aortic cross-clamping. This study was performed to determine the appropriate root pressure to maintain the heartbeat without causing deterioration of ventricular function. Study 1. Under partial CPB, the ascending aorta was cross-clamped in 6 pigs (group 1). Experimental data at various systolic aortic root pressures was analysed to determine the appropriate root pressure. Study 2. In group 2 (control, n＝6), the aorta was not clamped, while in group 3 (n＝6), the aorta was cross-clamped for 60 min and the systolic aortic root pressure was maintained at the pressure determined in study 1. Study 1. The diastolic coronary flow was stabilized at values comparable to that before initiation of CPB (6.6±1.4ml/beat) when the systolic aortic root pressure was above 80mmHg. Intracardiac pressure and the myocardial oxygen consumption (MvO2) seemed to be acceptable when the systolic aortic root pressure was below 100mmHg. Therefore, 90mmHg was selected for study 2. Study 2. Perioperative cardiac function did not differ between the groups. We concluded that 90mmHg was the systolic aortic root pressure appropriate for this method. |
| Keywords | aortic cross-clamp coronary flow root pressure cardiopulmonary bypass arch repair |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 391 |
| End Page | 397 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173809 |
| Web of Science KeyUT | 000285664200006 |
| JaLCDOI | 10.18926/AMO/41324 |
|---|---|
| FullText URL | 64_6_385.pdf |
| Author | Miyatake, Nobuyuki| Moriyasu, Hideyuki| Sakano, Noriko| Tada, Shinya| Suzue, Takeshi| Hirao, Tomohiro| |
| Abstract | The link between changes in estimated glomerular filtration rate (eGFR) and cigarette smoking was evaluated in Japanese male workers with a 5-year follow-up. We examined the data of 456 Japanese male workers, aged 22-70 years, who were taking no medications, and from this group, 286 men (43.5±8.2 years) were followed for 5-years. Habits of cigarette smoking were obtained during interviews by well-trained staff. The influence of cigarette smoking on eGFR was evaluated. In the first analysis, there was no significant difference in eGFR between subjects with and without cigarette smoking. In the second analysis, eGFR was significantly reduced after 5 years in all subjects. Changes in eGFR in subjects with cigarette smoking (－1.90±12.31ml/min/1.73m2) were significantly smaller than those in subjects without cigarette smoking (－4.97±12.05ml/min/1.73m2). At follow-up, we found that eGFR was weakly and negatively correlated with the number of cigarettes smoked (/day). The present study indicated that cigarette smoking may be an important modifiable factor for eGFR in Japanese male workers who are not taking any medications. |
| Keywords | cigarette smoking estimated glomerular filtration rate (eGFR) male worker |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 385 |
| End Page | 390 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173808 |
| Web of Science KeyUT | 000285664200005 |
| JaLCDOI | 10.18926/AMO/41323 |
|---|---|
| FullText URL | 64_6_375.pdf |
| Author | Kariya, Shin| Cureoglu, Sebahattin| Fukushima, Hisaki| Morita, Norimasa| Baylan, Muzeyyen Y.| Maeda, Yukihide| Nishizaki, Kazunori| Paparella, Michael M.| |
| Abstract | This study examined whether pathological findings were present in cochlear vessels for patients with diabetes mellitus. Twenty-six temporal bones from 13 patients with type 1 diabetes mellitus and 40 temporal bones from 20 patients with type 2 diabetes mellitus were examined. Type 2 diabetic temporal bones were divided into 2 groups according to diabetic management (22 temporal bones with insulin therapy, and 18 with oral hypoglycemic drugs). Age-matched normal control temporal bones were also selected. The vessel wall thickness in the cochlear spiral modiolar artery was measured under a light microscope, and the vessel wall ratio (vessel wall thickness/outer diameter of the vessel×100) was calculated. The vessel wall thickness and vessel wall ratio in type 1 diabetes mellitus were significantly greater than in normal controls. Type 2 diabetic patients with insulin therapy showed significantly greater vessel wall thickness and vessel wall ratios than controls. In type 2 diabetes mellitus, the vessel wall thickness and vessel wall ratio were greater in patients treated with insulin therapy than in those treated with oral hypoglycemic agents. Type 2 diabetic patients with insulin therapy showed an increased vessel wall thickness and vessel wall ratio compared to patients with type 1 diabetes mellitus. In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls. |
| Keywords | diabetes mellitus temporal bone cochlear spiral modiolar artery hearing loss |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 375 |
| End Page | 383 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173807 |
| Web of Science KeyUT | 000285664200004 |
| JaLCDOI | 10.18926/AMO/41322 |
|---|---|
| FullText URL | 64_6_367.pdf |
| Author | Tantular, Indah S.| Matsuoka, Hiroyuki| Kasahara, Yuichi| Pusarawati, Suhintam| Kanbe, Toshio| Tuda, Josef S. B.| Kido, Yasutoshi| Dachlan, Yoes P.| Kawamoto, Fumihiko| |
| Abstract | We conducted a field survey of glucose-6-phosphate dehydrogenese (G6PD) deficiency in the eastern Indonesian islands, and analyzed G6PD variants molecularly. The incidence of G6PD deficiency in 5 ethnic groups (Manggarai, Bajawa, Nage-Keo, Larantuka, and Palue) on the Flores and Palue Islands was lower than that of another native group, Sikka, or a nonnative group, Riung. Molecular analysis of G6PD variants indicated that 19 cases in Sikka had a frequency distribution of G6PD variants similar to those in our previous studies, while 8 cases in Riung had a different frequency distribution of G6PD variants. On the other hand, from field surveys in another 8 ethnic groups (Timorese, Sumbanese, Savunese, Kendari, Buton, Muna, Minahasa, and Sangirese) on the islands of West Timor, Sumba, Sulawesi, Muna and Bangka, a total of 49 deficient cases were detected. Thirty-nine of these 49 cases had G6PD Vanua Lava (383T＞C) of Melanesian origin. In our previous studies, many cases of G6PD Vanua Lava were found on other eastern Indonesian islands. Taken together, these findings may indicate that G6PD Vanua Lava is the most common variant in eastern Indonesian populations, except for Sikka. |
| Keywords | Glucose-6-phosphate dehydrogenase deficiency rapid G6PD test eastern Indonesian population molecular analysis G6PD Vanua Lava |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 367 |
| End Page | 373 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173806 |
| Web of Science KeyUT | 000285664200003 |
| JaLCDOI | 10.18926/AMO/41321 |
|---|---|
| FullText URL | 64_6_359.pdf |
| Author | Yada, Yoshihiko| Sakate, Yoji| Kawamura, Yoshihiro| |
| Abstract | The results of submucosal electrocoagulation (SEC), a new radical operation for prolapsed hemorrhoids, in 403 patients with third- or fourth-degree hemorrhoids are reported. After resecting the anal skin tags that coexisted with prolapsed hemorrhoids, the hemorrhoidal varices could be resected and electrically coagulated through the wound without cutting the anal canal epithelium by using a fine needle-type electric knife. The results of this series indicated that SEC could dramatically reduce the incidence of the postoperative complications that sometimes occur after conventional hemorrhoid-ectomy, such as severe anal pain, massive anal bleeding and anal stenosis. Moreover, SEC could ensure that operated patients make an early return to social activities and have a satisfactory quality of life. Relapse of prolapsed hemorrhoids after SEC was rare. |
| Keywords | submucosal electrocoagulation method (SEC) hemorrhoids hemorrhoidectomy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 365 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173805 |
| Web of Science KeyUT | 000285664200002 |
| JaLCDOI | 10.18926/AMO/41320 |
|---|---|
| FullText URL | 64_6_351.pdf |
| Author | Furumatsu, Takayuki| Asahara, Hiroshi| |
| Abstract | Chondrocyte differentiation is the fundamental process in skeletal development. From the mesenchymal condensation of chondroprogenitors to the hypertrophic maturation of chondrocytes, chondrogenesis is sequentially regulated by cross-talk among transcription factors, growth factors, and chromatin structure. The master transcription factor Sry-type HMG box (Sox) 9 has an essential role in the expression of chondrogenic genes through the association with Sox9-binding sites on its target genes. Several transcription factors and coactivators, such as Scleraxis/E47 and p300, cooperatively modulate the Sox9-dependent transcription by interacting with Sox9. The Sox9-related transcriptional apparatus activates its target gene expression through p300-mediated histone acetylation on chromatin. The transforming growth factor (TGF)-β superfamily also plays a key role in chondrocyte differentiation. The TGF-β-regulated Smad3/4 complex activates Sox9-dependent transcription on chromatin by associating with Sox9 itself, and by recruiting p300 onto Sox9. These findings suggest that the epigenetic status including histone modification and chromatin structure, directly influences Sox9-regulated chondrocyte differentiation. In this article, we review the regulators of Sox9 expression itself, modulators of posttranslational Sox9 function, and Sox9-associating factors in the Sox9-dependent epigenetic regulation during chondrogenesis. |
| Keywords | Sox9 TGF-β-Smad3 coactivator p300 scleraxis/E47 chondrogenesis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-12 |
| Volume | volume64 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 351 |
| End Page | 357 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21173804 |
| Web of Science KeyUT | 000285664200001 |
| Author | Miyata, Nobuhiro| |
|---|---|
| Published Date | 1959-11-20 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue12-1 |
| Content Type | Journal Article |
| Author | Fujioka, Yukio| Fukui, Tetsuya| Sakurai, Yasuro| Kobayashi, Toshiyuki| |
|---|---|
| Published Date | 1959-10-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue11-2 |
| Content Type | Journal Article |
| Author | Fujioka, Yukio| Fukui, Tetsuya| Kobayashi, Toshiyuki| |
|---|---|
| Published Date | 1959-10-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue11-2 |
| Content Type | Journal Article |
| Author | Tokiya, Tatsuo| |
|---|---|
| Published Date | 1959-10-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue11-2 |
| Content Type | Journal Article |
