| ID | 13803 |
| Eprint ID | 13803
|
| FullText URL | |
| Title Alternative | NRK49-F cell proliferation activity of urine in renal diseases
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| Author |
Eguchi, Junji
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| Abstract | To evaluate the roles of transforming growth factor-β (TGF-β) on the glomerular cell proliferation and sclerosis, a new colorimetric bioassay system for urinary excretion of TGF-β has been developed by using NRK49-F cell culture. The urinary TGF-β activity was detected by this method in focal glomerular sclerosis (FGS) and purpura nephritis but not in minimal change nephrotic syndrome and IgA nephropathy. The bioassayed TGF-β activity was comfirmed by a blocking experiment using a neutralizing antibody and by Western immuno-blotting. These findings suggest that TGF-β plays an important role in the progression of the glomerular leisions, in FGS and purpura nephritis.
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| Keywords | TGF-β
NRK49-F
colorimetric bioassay
|
| Note | 原著
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| Published Date | 1994-08
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume106
|
| Issue | issue7-8
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
|
| Start Page | 875
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| End Page | 882
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/106/7-8/106_7-8_875/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/
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| language |
Japanese
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| Copyright Holders | Copyright© 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
|
