result 325 件
| Author | Takagi, Shin| Mizukawa, Nobuyoshi| Fukunaga, Joji| Ishida, Nobuhisa| Maruo, Yukinori| Kannyama, Manabu| Kimata, Yoshihiro| Koushima, Isao| |
|---|---|
| Published Date | 2009-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/14842 |
|---|---|
| Title Alternative | The relationship between the magnetic resonance imaging of the lumbar spine and lowback pain |
| FullText URL | 72_066_070.pdf |
| Author | Takata, Shingo| Yokoi, Tadashi| Nishida, Norikazu| Okamoto, Makoto| Tsugeno, Hirofumi| Ashida, Kozo| Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Niiya, Kenji| Tanimoto, Mitsune| |
| Abstract | (目的) MRlは腰痛をきたす疾患の診断に必須な検査法である｡腰痛と腰椎MRl所見との関係を明らかにすることを目的として検討した｡(対象と方法)腰痛を訴えた30例を対象とし､腰椎MRl所見の頻度を調査した｡全例に温泉療法を施行した｡ (結果)全症例において腰椎MRl上異常所見を認めた｡少なくとも1つ以上の椎間板の変性病変をもつ症例は30例中27例(90% )で､椎間板変性はL4/5levelで最も多く認められた(30例中18例)｡椎間板ヘルニア を示す症例は30例中10例(33.3% )であった｡神経根圧迫を持つ症例は30例中8例(26.7% )であった｡腰椎圧迫骨折を持つ症例は30例中6例(20% )であった｡温泉療法により腰痛が改善した症例は30例中17例(56.7% )であった｡ (結論)腰痛症患者は腰椎MR止異常所見を有した｡温泉療法により腰痛の改善を認めたので､MRL上で認めた形態学的異常は必ずしも機能的異常や症状に直結しないと思われた｡ |
| Keywords | 腰痛症 (Disc disease) MRl (Magnetic resonance imaglng) 椎間板変性 (Lumbar spine) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 66 |
| End Page | 70 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308103 |
| JaLCDOI | 10.18926/14841 |
|---|---|
| Title Alternative | Two male steroid-dependent asthmatics treated with etidronate |
| FullText URL | 72_062_065.pdf |
| Author | Tsugeno, Hirofumi| Okamoto, Makoto| Takata, Singo| Yokoi, Tadashi| Nishida, Kazunori| Ashida, Kozo| Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Nakai, Mutsuo| Akiyama, Tsuneo| Hasegawa, Hisakazu| Tsuji, Takao| |
| Abstract | 男性のステロイド依存性気管支喘息患者にエチドロネートを4年間の長期間にわたり投与した経験を得たので報告する｡症例は,男性のステロイド依存性気管支喘息で,エチドロネート200mg/日･14日間投与を4ケ月おきに4年間にわたり反復投与し,活性型ビタミンD製剤 (VD)投与と併用した2例と,活性型VD製剤を単独授与した2例｡椎体圧迫骨折数,境骨耗骨密度,海綿骨骨密度,皮質骨骨密度について,椎体X線像,PQCT(Stratec XCT960)を用いて4ケ月毎に測定し,48ケ月後の効果を検討した｡エチドロネートを投与した症例1では,総骨密度と海綿骨はやや増加を認め皮質骨密度は減少していた｡エチドロネートを授与した症例2では,総骨密度,海綿骨,皮質骨密度はいずれも減少を認めたが,VD単独投与した2例よりもやや減少が抑制されていたようであった｡VD単独投与した2例ではいずれの項目も減少を認めた｡これらの症例からは,エチドロネートは男性のステロイドによる骨傷害にも有効と考えられたが,現在投与継続途中であり,今後さらに検討を続ける必要がある｡ |
| Keywords | エチドロネート 男性 ステロイド 気管支喘息 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 62 |
| End Page | 65 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308188 |
| JaLCDOI | 10.18926/14840 |
|---|---|
| Title Alternative | Multidetector-CT findings of dissecting aortic aneurysum and coronary artery disease. Based on the case of dissecting aortic aneurysum and coronary artery disease. |
| FullText URL | 72_055_061.pdf |
| Author | Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Takata, Shingo| Yokoi, Tadashi| Nakai, Mutsuo| Makino, Hirofumi| Tanizaki, Yoshiro| |
| Abstract | 2000年になり多列検出器高速CT (Multi-detector CT,以下MDCT)が出現し,大動脈疾患や心電図同期での冠動脈狭窄病変診断への臨床応用が開始された.当院でも2001年7月からMDCTが稼動し,日常臨床診療に貢献している. 今回,解離性上行大動脈瘤(DeBakeyII)(以下DAA)と冠動脈疾患(LAD# 7の閉塞)を合併した患者を診療した.MDCTによるCT - Angiography (以下CTA)が両者の診断に非常に有用であった.患者の負担は100mlの末梢静脈内への造影剤の投与と約数十秒間の呼吸停止だけで,解離性大動脈瘤並びに冠動脈狭窄病変の診断にそれぞれ非常に有用であった.三次元診断の鮮明な画像が得られ,かつ低侵襲度のMDCT並びにCTAは,今後益々臨床の場で血管造影検査の強力なファーストチョイスの診療手段になると考える. |
| Keywords | 解敵性大動脈瘤 (disecting aortic aneurysum) 冠動脈 (coronary artery) 狭心症 (anglna Pectoris) 多列検出器CT(マルチスライスCT) (MDCT) CT血管造影 (CT-Angiography) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 55 |
| End Page | 61 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308046 |
| JaLCDOI | 10.18926/14839 |
|---|---|
| Title Alternative | 脂質代謝に関連した気管支喘息患者における白血球ロイコトリエン産生能に対するα-リノレン酸食の効果 |
| FullText URL | 72_045_054.pdf |
| Author | Okamoto, Makoto| Mitsunobu, Fumihiro| Ashida, Kozo| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Nishida, Norikazu| Yokoi, Tadashi| Takata, Shingo| Tanizaki, Yoshiro| Tanimoto, Mitsune| |
| Abstract | Dietary sources of a -linolenic acid, such as perilla seed oil, may have the capacity to inhibit the generation of leukotrienes (LTs) by leucocytes in patients with
asthma, as has been reported with the consumption of other long - chain n- 3 fatty a-cids.
The factors affecting the suppression of leukotriene (LT) C4 generation by leucocytes were examined by comparing the clinical features of patients with asthma who had been given dietary perilla seed oil (n - 3 fatty acids). Group A consisted of patients in whom the leucocyte generation of dietary perilla seed oil LTC4 was suppressed by this procedure. Group B consisted of those in whom LTC4 generation was not suppressed. LTC4 generation by leucocytes significantly decreased in group A for two (P<0.05) and four weeks (P |
| Keywords | alpha -linolenic acid leukotrieneC4 bronchial asthma lipometabolism |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 45 |
| End Page | 54 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308212 |
| JaLCDOI | 10.18926/14838 |
|---|---|
| FullText URL | 72_038_044.pdf |
| Author | Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| |
| Abstract | Changes in the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes after spa therapy were examined in 30 patients with asthma.
1. The efficacy of spa therapy was marked in 8 (26.7%), and moderate in 16 (53.3%) of 30 patients with asthma, and slight or no efficacy of the therapy was observed in the residual 6 patients (20.0%).
2. Bronchial reactivity to methacholine was the highest in
patients with slight or no efficacy of spa therapy, however. there were no significant differences among the three groups classified by clinical efficacy.
3. The generation of LTC4 was significantly higher in patients with slight or no efficacy compared with the
generation in those with marked (p |
| Keywords | asthma spa therapy bronchial hyperresponsiveness LTB4 LTC4 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 38 |
| End Page | 44 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308539 |
| JaLCDOI | 10.18926/14837 |
|---|---|
| FullText URL | 72_031_037.pdf |
| Author | Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| Ochi, Koji| Tsuji, Takao| |
| Abstract | The purpose of this study is to establish a new, non - invasive diagnostic technique for peripheral circulation in patients with diabetes mellitus in the early stage of arteriosclerosis obliterans (ASO) as one of the complications of diabetes mellitus. We observed peripheral circulation quantitatively by thermography and Laser- Doppler blood flowmetry. The body surface peripheral circulation in 27 patients with diabetes mellitus, including 14 males and 13 females with a mean age of 67.4 years (range from 51-82 years), and with a mean hemoglobin A1C (HbA1C) 019.5% (range from 6.8%-13.0%), and who were suffering coldness, numbness or pain in their feet, was examined using thermography and Laser- Doppler blood flowmetry. Thermographic results
were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio= [Total counts of thermography (Pixels) over temperature (T) after cold -loading] + [Initial counts over T after hot-loading] Xl00 (%). Results of recovery ratios for 27 cases were 0% - 93.5%, and the average was 34.0%. At the same time, the blood flow after cold -loading was 0.91 - 5. 36ml/min/lOOg tissue and the average was 2.04ml/min/l00g tissue. We found that the recovery ratio
and the blood flow were correlated (r=O. 634, p |
| Keywords | diabetes mellitus (糖尿病) peripheral circulation (末梢循環) thermography (サーモグラフィー) Laser-Doppler blood flowmetry (レーザードプラー血流計) blood flow (血流量) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 31 |
| End Page | 37 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308058 |
| JaLCDOI | 10.18926/14836 |
|---|---|
| Title Alternative | 高齢者気管支喘息の臨床病態におけるロイコトリエンB4,C4の役割. 気道過敏性とFEV1.0%との関連 |
| FullText URL | 72_023_030.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| |
| Abstract | The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 67 patients with asthma. 1. The generation of leukotriene B4 (LTB4) by leucocytes was significantly more increased in patients with asthma than in those with pulmonary emphysema (PE) and healthy subjects. The generation of leukotriene C4 (LTC4) was also signficantly more increased in patients with asthma compared to the generation in those with PE and healthy subjects. The generation of both LTB4 and LTC4 was significantly more increased in patients with PE than in healthy subjects. 2. The generation of both LTB4 and LTC4 was larger in patients with asthma over age 70 than in those of other age groups, however, the difference was not significant. 3. The generation of LTC4 was significantly higher in attack stage than in non-attack stage in all age groups of patients with asthma, however, the generation of LTB4 was not significantly different between the two stages. 4. Bronchial hyperresponsiveness to methacholine in patients with asthma tended to decrease with aging, and the bronchial hyperresponsiveness was to a certain extent correlated with the generation of LTB4, but not LTC4. 5. The generation of LTC4 was correlated with value of FEV1.0%. These results may suggest that both LTB4 and LTC4 participate in the pathophysiology of asthma in the elderly. |
| Keywords | asthma LTB4 LTC4 FEV1.0% bronchial hyperresponsiveness |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 23 |
| End Page | 30 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308466 |
| JaLCDOI | 10.18926/14835 |
|---|---|
| Title Alternative | 気管支喘息における気管支肺胞洗浄液中の細胞成分に対する加齢および副腎皮質ホルモンの影響 |
| FullText URL | 72_016_022.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| |
| Abstract | Effects of aging and glucocorticoid therapy on bronchoalveolar lavage (BAL) cells, particularly lymphocytes, neutrophils and eosinophils, were examined in 81 patients with asthma. 1. The proportion of BAL lymphocytes tended to increase with aging in asthmatics under age 69 years, and the proportion was significantly higher in patients with asthma between the ages of 60 and 69 than in those under age 39 and between the ages of 40 and 49. 2. The proportions of BAL neutrophils and eosinophils were not related to aging. 3. The proportion of BAL lymphocytes was higher in patients without glucocorticoid therapy than in those with steroid-dependent intractable asthma (SOIA) in those under age 69 years. In patients between the ages of 50 and 59, the proportion of BAL lymphocytes was significantly higher in patients without glucocorticoids than in those with SOIA. 4. The proportion of BAL neutrophils was higher in patients without glucocorticoid therapy than in those with SOIA, and the difference was significant in patients between the ages of 60 and 69. 5. The proportion of BAL eosinophils was not related to glucocorticoid therapy. These results suggest that the proportion of BAL lymphocytes and neutrophils is affected by aging and glucocorticoid therapy, but not BAL eosinophils. |
| Keywords | aging asthma glucocorticoid therapy BAL cells |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 16 |
| End Page | 22 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308605 |
| JaLCDOI | 10.18926/14834 |
|---|---|
| Title Alternative | HRCT上の肺のLow Attenuation Areaおよび肺機能により評価された高齢者善喘息の特徴 |
| FullText URL | 72_009_015.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Nakai, Mutsuo| Tanizaki, Yoshiro| |
| Abstract | The clinical significance of low attenuation area <-950 HU of the lungs on high - resolution computed tomography (HRCT) was evaluated in 80 patients with asthma in relation to patient age, CT number, pulmonary function including % residusal volume (% RV) and % DLco, and generation of leukotrienes B4 and C4 by leucocytes.
1. The % LAA (<- 950 HU) of the lungs showed a tendency to increase significantly with aging; the % LAA was significantly larger in elderly patients over the age of 60 years than in those under the age of 49 years. The CT number was also significantlyincreased with aging.
2. The values of % FVC, % FEV1.0, and FEV1.0% were
significantly decreased in elderly patients over age 70 compared with the values in those under age 49.
3. The value of % residual volume (% RV) tended to increase significantly with aging; the value in patients over the age of 70 years was significantly larger in those between the ages of 50 and 59 (p |
| Keywords | low attenuation area of the lung CT number residual volume DLco aging |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 9 |
| End Page | 15 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308131 |
| JaLCDOI | 10.18926/14822 |
|---|---|
| Title Alternative | Spa therapy for patients with respiratory disease. Analysis of 1934 patients admitted at Misasa Medical Branch for last 20 years from 1982 to 2001 |
| FullText URL | 72_001_008.pdf |
| Author | Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| |
| Abstract | 1982年1月より2001年12月までの20年間に当院へ入院した呼吸器疾患患者1934例のうち閉塞性換気障害を示す肺疾患1641例(気管支喘息BA+慢性閉塞性呼吸器疾患COPD)を対象に,5年間ごとに年齢,地域分布などの経年変化について検討を加えた｡ 1.最近20年間に当院へ入院した閉塞性換気障害を示す呼吸器疾患1641例のうち,気管支喘息は1226例(74.7%)であった｡閉塞性呼吸器疾患のなかで気管支喘息の占める割合は,最初の5年間では106例中 57例(53.8%),1987年からの5年間では71.7% (271/378),1992年からの5年間では73.6% (433/588)で,最近の5年間では53.9% (465/862)と最近ではその割合がやや低下する傾向が見られた｡ 2.全ての気管支喘息のなかでステロイド依存性重症難治性喘息(SDIA)の割合は,最初の5年間をのぞけばほぼ横ばいで最近の5年間では35.3%であった｡COPDのなかでの肺気腫の割合は,近年増加の傾向を示し,最初の5年間の4.7% (5/106)に対して最近の5年間では20.2% (174/862)であった｡ 3.年齢別検討では,閉塞性換気障害を示す全ての症例のうち60才以上の症例の割合は,最初の5年間では30.1%であったが,その後増加の傾向を示し,最近の5年間では68.0%であった｡ 4.地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,この20年間の鳥取県外(遠隔地)からの入院患者は1641例中853例(52.0%)であった｡また,岡山,大阪,広 島,兵庫,東京,愛媛,山口,京都などからの入院症例が多い傾向が見られた｡なお,入院患者の出身県は,35都道府県に及んでいた｡ |
| Keywords | 気管支喘息 (asthma) 肺気腫 (pulmonary emphysema) 温泉療法 (Spa therapy) 高齢患者 (aged patients) 遠隔地 (distant area) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308041 |
| JaLCDOI | 10.18926/14775 |
|---|---|
| Title Alternative | A case of anti - neutrophil cytoplasmic autoantibody-associated vasculitis: Resolution after early diagnosis |
| FullText URL | 73_088_092.pdf |
| Author | Ichikawa, Hirohisa| Ashida, Kozo| Ono, Katsuichiro| Takata, Shingo| Yokoi, Tadashi| Nagata, Takuya| Okamoto, Makoto| Tsugeno, Hirohumi| Nishida, Norikazu| Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Noguchi, Yoshinori| Tanimoto, Mitsune| |
| Abstract | 症例は76歳男性03年前肺気腫と診断された｡今回呼吸器リハビリテーション目的で当院に入院の運びとなった｡入院時より37-38'Cの発熱を認め,下気道感染を疑い抗生剤で加療したが改善しなかった.入院時の検尿検査で蛋白･潜血陽性であり,血清MPO-ANCAが307U/mlと高値を示した｡血清クレアチニン値も徐々に上昇してきたため,MPO-ANCA関連血管炎と診断した.プレドニゾロン投与を開始したところ,症状及び検査所見は速やかに改善した. |
| Keywords | ANCA関連血管炎 早期診断 顕微鏡的多発血管炎 |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 88 |
| End Page | 92 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308580 |
| JaLCDOI | 10.18926/14774 |
|---|---|
| Title Alternative | A case of Parkinson's disease associated with bromocriptine - induced leukopenia and throm-bocytopenia |
| FullText URL | 73_084_087.pdf |
| Author | Takata, Shingo| Mifune, Takashi| Mitsunobu, Fumihiro| Okamoto, Makoto| Nishida, Norikazu| Tsugeno, Hirofumi| Ashida, Kozo| Hosaki, Yasuhiro| Yokoi, Tadashi| Tanizaki, Yoshiro| Niiya, Kenji| Tanimoto, Mitsune| |
| Abstract | 症例は67歳,女性｡以前からパーキンソン病にて加療されていたが,リハビリテーション目的で当院入院した.入院時白血球数,血小板数正常であったが,bromocriptine投与開始後白血球減少,血小板減少を認めた.薬剤性白血球減少症及び血小板減少症を疑い, bromocriptine投与中止するとともにfilgrastim投与により,白血球減少,血小板減少は改善した。誘発試験施行し白血球減少を認めた｡Bromocriptineによる白血球減少症,血小板減少症の報告は少なく,我々の検索しえた範円内では本症例を含めて2例のみであった。Bromocriptineには安全性や神経保護作用に関して多くのデータの蓄積があるが,安全性に十分な注意が必要であると考えられた｡ |
| Keywords | パーキンソン病 (Parkinson's disease) ブロモクリプチン (Bromocriptine) 白球血減少症 (Leukopenia) 血小板減少症 (Thrombocytopenia) フィルグラスチム (Filgrastim) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 84 |
| End Page | 87 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308217 |
| JaLCDOI | 10.18926/14773 |
|---|---|
| Title Alternative | ’あくび’と胸痛を訴えた気管支喘息の1症例 |
| FullText URL | 73_081_083.pdf |
| Author | Mitsunobu, Fumihiro| Ashida, Kozo| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Nagata, Takuya| Takata, Shingo| Tanizaki, Yoshiro| |
| Abstract | We present a case of a patient with asthma who developed yawning associated with anterior chest pain. She was admitted due to severe anterior chest pain, wheezing and dyspnea. Although the frequency of the symptoms decreased, she began to experience frequent episodes of yawning at night accompanied by tears. While she experienced yawning, although PEF (peak expiratory flow) decreased, no asthmatic symptoms, such as wheezing or dyspnea were observed. The yawning was improved markedly by bronchodilators and a leukotriene receptor antagonist, and moderately improved by corticosteroids. We speculated that yawning is a clinical manifestation of asthma that responds to treatment. |
| Keywords | yawning chest pain nocturnal dyspnea asthma |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 81 |
| End Page | 83 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308373 |
| JaLCDOI | 10.18926/14772 |
|---|---|
| Title Alternative | Influences of aging and cigarette smoking on pathophysiology in elderly patients with asthma (2) |
| FullText URL | 73_093_101.pdf |
| Author | Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Nagata, Takuya| Takata, Shingo| Yokoi, Tadashi| |
| Abstract | 高齢者気管支喘息について.IgEにmediateされるアレルギー反応の特徴、臨床病態,肺機能(換気機能,ガス交換),気腫化傾向,治療上の問題点などを検討した. 1.高齢者喘息におけるIgE抗体の関与は予想外に多く,しかもアレルギーの家族歴を有する症例で特に高度であった。また,加齢とともに感作される抗原の種類が異なってくることが示唆された。 2.臨床病態では,単純性気管支攣縮型に比べ,気管支攣縮+過分泌型や細気管支閉塞型が増加する傾向が見られた｡ 3.肺機能では,airflow (% FVC,FEV1.0%)ゃlung volume(% RV)をあらわすパラメーターは,いずれも70才以上の症例で若青年者喘息に比べ有意に低下していることが示された｡また,transfer factor(% DLco)も70才以上の症例では有意の低下傾向が見られた。 4.HRCT上の1950HU以下の肺の% UIAは,加齢とともに増加する傾向を示し,% RVの増加と同様肺の気腫化傾向が見られること,しかし,この現象が肺気腫へと移行することはないことが示された. 5.治療上では,薬物療法よりも気道の浄化を促す吸入や水中運動(温泉療法など)が重要であると考えられた｡ |
| Keywords | 高齢者喘息 IgE抗体 % RV % DLco 気腫可傾向 |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 93 |
| End Page | 101 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308220 |
| JaLCDOI | 10.18926/14770 |
|---|---|
| Title Alternative | QOL in OA patients |
| FullText URL | 73_072_074.pdf |
| Author | Yokoi, Tadashi| Senda, Masuo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Nishida, Norikazu| Tsugeno, Hirofumi| Okamoto, Makoto| Nagata, Takuya| Takata, Shingo| Tanizaki, Yoshiro| Inoue, Hajime| |
| Abstract | 近年QOLが重視されるようになってきている｡MOS short form 36 health survey(以下SF-36と略す)は,国際的レベルでの基準とされるべく開発された非疾患特異的HRQOL尺度である.今回,我々は当院でリハビリテーションをうけているOA患者を対象に温泉療法の効果をSF-36を用いてQOLの変化を調べたoSF-36の8項目をそれぞれ算出し,温泉療法前後でのQOLの比較を行った｡pCSは36.4から37.1へ,MCSは53.0から55.4へ上昇したことより,身体･健東面ともに効果があると考えられた｡ |
| Keywords | SF-36 生活の質 (Quality of Life) 関節症 (Osteoarthritis) |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 72 |
| End Page | 74 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308372 |
| JaLCDOI | 10.18926/14769 |
|---|---|
| Title Alternative | The level of plasma BNP continued remarkably high in the elderly presented with old myocardial infarction. |
| FullText URL | 73_064_071.pdf |
| Author | Nishida, Norikazu| Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Nagata, Takuya| Yokoi, Tadashi| Nakai, Mutsuo| Makino, Hirofumi| Tanizaki, Yoshiro| |
| Abstract | 心不全が比較的良好にコントロールされているのにもかかわらず,高齢の陳旧性心筋梗塞後患者等で脳性ナトリウム利尿ペプチド(BNP)の異常高値が持続する場合がある.今回,また超高齢の心不全患者で同所見を認めたので,考察を含めて報告する. 93歳高齢の陳急性心筋梗塞患者で,BNP1600-1200の著明な高値が持続した.主に心尖部と一部の前側壁の陳旧性心筋梗塞症であったが,利尿薬等による治療によって心不全はコントロールできており,救急入院時を除いては,鬱血性心不全の状態ではなかった.心願超音 波検査でも心内圧の上昇や下大静脈の拡張も認めなかった.利尿薬を増量するとむしろ脱水による腎機能障害の増悪を認めていた. 入院中に狭心痛を認めることがあり,心筋逸脱酔素の軽度の上昇を認めた.BNPの著明な高値持続は,陳旧性心筋梗塞後の心臓機能障害や左室肥大,僧帽弁閉頚不全等による慢性心不全･心負荷のための心筋でのBNP合成･分泌元進の他に,新たな小梗塞(非貫壁性心筋梗塞)や持続する無症候性の心筋虚血による心筋でのBNP合成･分泌亢進,高齢によるBNPクリアランスの低下と分泌の持続的亢進,慢性腎機能障害によるBNPクリアランスの低下,心筋障害後の心筋再構築(リモデリング)の訳節と心筋繊維化抑制の為に合成が元進していると考えられる.更に,いわゆる老人肺･慢性呼吸機能低下による右心系の負荷による心室からの分泌元進,ステロイドホルモン内服による鉱井コルチコイド作用,貧血,低栄養状態等の様々な要因が重なっているものと考えられた. 心臓でBNPの産生･分泌が亢進するのは,心不全に伴う全身の体液量バランスや血行動態等の悪化を改善,調節するためだけではなく,心臓自身のリモデリングの調節･抑制,再構築の調薪のため,さらには心臓･心筋の繊維化や拡張障害の増悪を抑制するための自己防衛 機構としても機能している.心臓は,単に循環系のポンプではなく,利尿ペプチドホルモンを分泌する内分泌器官でもある. 一般的に加齢に伴いBNPは上昇してくる.特に70歳以上の高齢者では顕著になる.考察ではその点についても新たな文献的考察も含めて報告し,高齢者のBNPの捉え方と治療についても述べる. |
| Keywords | bronchial asthma spa therapy perilla seed oil alpha -linolenic acid Leukotriene C4 |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 64 |
| End Page | 71 |
| ISSN | 1348-1258 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308534 |
| JaLCDOI | 10.18926/14768 |
|---|---|
| Title Alternative | 気管支喘息に対する温泉療法とα-リノレン酸強化食の効果 |
| FullText URL | 73_055_063.pdf |
| Author | Okamoto, Makoto| Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Nishida, Norikazu| Nagata, Takuya| Yokoi, Tadashi| Takata, Shingo| Tanizaki, Yoshiro| Tnimoto, Mitsune| |
| Abstract | N-3 fatty acids are reportedly effective for asthma. In addition, spa therapy has been reported to be effective for patients with asthma. In the present study, the effects of spa therapy combined with perilla seed oil- rich diet (rich in n-3 fatty acid)were examined on asthma. A total of 14 asthmatic patients had a complex spa therapy and consumed a perilla seed oil- rich diet - rich in a -linolenic acid (alpha-LNA) for 8 weeks. Generation of leukotriene (LT) C4 by leucocytes, respiratory function were analyzed. The generation of LTC4 by leucocytes decreased significantly for 2, 4 and 8 weeks (P |
| Keywords | bronchial asthma spa therapy perilla seed oil alpha -linolenic acid Leukotriene C4 |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 55 |
| End Page | 63 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308428 |
| JaLCDOI | 10.18926/14750 |
|---|---|
| Title Alternative | 気管支喘息の low attenuation are (LAA) に対する長期喫煙の影響-4年間の経過観察- |
| FullText URL | 73_010_018.pdf |
| Author | Mitsunobu, Fumihiro| Ashida, Kozo| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Nagata, Takuya| Takata, Shingo| Yokoi, Tadashi| Nakai, Mutsuo| Tanizaki, Yoshiro| Tanimoto, Mitsune| |
| Abstract | Background-The influence of cigarette smoking on the pathogenesis of asthma in the elderly remains controversial. This study attempts to estimate longitudinal changes in HRCT (high resolution computed tomography) parameters and pulmonary function parameters obtained for ex-smokers and never-smokers in asthmatics during 4-yr follow-up period. Methods-Fourteen asthmatics (6 ex-smokers and 8 never-smokers) were studied to determine the influence of aging and cigarette smoking on pulmonary function, and mean lung density (MLD) and the relative area of the lung showing attenuation values less than -950 HU (RA950) on HRCT scans. Results-The values of FVC and FEV1, were significantly more decreased in asthmatics without a smoking history during 4-yr follow-up period. The values of FVC, FEV1, FEV1/FVC and DLco/VA were significantly decreased and RV/TLC were significantly increased in asthmatics with a smoking history over 4 years, and annual decline in FEV1 ex-smokers was larger than that in never-smokers. In the upper lung field, inspiratory MLD was observed to shift in a negative direction and inspiratory RA950 was found to increase during 4-yr observation period in ex-smokers, but not in never-smokers. In the middle lung field, inspiratory RA950 was significantly enhanced in both two groups. Although expiratory MLD, expiratory RA950 and exp RA950/ins RA950 were observed to change significantly during the observation period in ex-smokers, no changes were observed in never-smokers. Conclusion-These results suggest that aging augments airspace enlargement predominantly in the middle lung field, while long term cigarette smoking further worsens emphysematous alterations in the upper lung field. |
| Keywords | lung density high resolution computed tomography asthma |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 10 |
| End Page | 18 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308656 |
| Author | Doihara, Hiroyoshi| |
|---|---|
| Published Date | 1990-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume102 |
| Issue | issue1-2 |
| Content Type | Journal Article |
