| ID | 56181 |
| JaLCDOI | |
| FullText URL | |
| Author |
Miyake, Susumu
Department of Pediatrics, Tokiwa-Kure Facilities for Persons with Severe Motor and Intellectual Disabilities
Sugita, Makio
Department of Pediatrics, Tokiwa-Kure Facilities for Persons with Severe Motor and Intellectual Disabilities
Okazaki, Tomio
Department of Pediatrics, Tokiwa-Kure Facilities for Persons with Severe Motor and Intellectual Disabilities
Takenaka, Mieko
Department of Child Neurology, Hiroshima City Hiroshima Citizens Hospital
Kuwabara, Kentarou
Department of Child Neurology, Hiroshima City Hiroshima Citizens Hospital
Ogawa, Kazunori
Department of Child Neurology, Hiroshima City Hiroshima Citizens Hospital
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| Abstract | A 22-year-old Japanese male with trisomy 21 was diagnosed with West syndrome at 4 months old. After the suppression of epileptic spasms using adrenocorticotropic hormone therapy, he had complex partial seizures and bilateral frontal epileptic discharges on EEG. Although the introduction of topiramate (TPM) decreased the seizures during wakefulness, frequent episodes of brief eye-opening appeared during sleep while the patient was taking TPM (400 mg/day). EEG showed fast activity at the times of eye-opening. The episodes of eye-opening during sleep and the fast activities disappeared upon TPM discontinuation. This is the first report of TPM-induced microseizures similar to benzodiazepine-induced microseizures.
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| Keywords | topiramate
microseizures
paroxysmal fast activity
side effects
seizure aggravation
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| Amo Type | Case Report
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| Publication Title |
Acta Medica Okayama
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| Published Date | 2018-08
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| Volume | volume72
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| Issue | issue4
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| Publisher | Okayama University Medical School
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| Start Page | 419
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| End Page | 422
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| ISSN | 0386-300X
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| NCID | AA00508441
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| Content Type |
Journal Article
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| language |
English
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| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School
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| File Version | publisher
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| Refereed |
True
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| PubMed ID |
