| ID | 68953 |
| Author |
Kobori, Yuito
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Tokushige, Keisuke
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Abe, Takumi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Kaken ID
researchmap
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| Abstract | Despite recent advances in the synthesis of 2,3-diaminoindole derivatives, construction of 2,3-diaminoindolines, whose two amine moieties on each molecule differ from one another has yet to be achieved. In this work, we developed a concise one-pot protocol for differentiated diamination involving reacting a C2,C3-electrophilic indole reagent with amines to access a variety of previously inaccessible 2,3-diaminoindolines. Furthermore, the synthetic utility of this protocol was demonstrated by a successful gram-scale reaction and further transformation of the 2,3-diaminoindolines.
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| Note | This is an Accepted Manuscript of an article published by Royal Society of Chemistry (RSC).
This fulltext file will be available in Jun. 2026.
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| Published Date | 2025
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| Publication Title |
Organic & Biomolecular Chemistry
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| Publisher | Royal Society of Chemistry (RSC)
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| ISSN | 1477-0520
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| NCID | AA1168650X
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | © The Royal Society of Chemistry 2025
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| File Version | publisher
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| PubMed ID | |
| DOI | |
| Related Url | isVersionOf https://doi.org/10.1039/d5ob00877h
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| 助成情報 |
JPMJSP2126:
( 国立研究開発法人科学技術振興機構 / Japan Science and Technology Agency )
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