ID | 34204 |
FullText URL | |
Author |
Nakamura, Yuichi
Yamamoto, Hiroshi
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Abstract | (R)-2-Tosyloxypropanal (4) was prepared from D-mannitol in a 7-step sequence (51% overall yield). Addition of dialkyl phosphonates to 4 in the presence of titanium isopropoxide and the subsequent treatment with DBU stereoselectively afforded, in one-pot, fosfomycin dimethyl (5a) and dibenzyl (5b) esters both in 58% isolated yield.
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Keywords | Fosfomycin
Epoxidation
C-P Bond Formation
Phosphonate Addition
Diastereoselectivity
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Published Date | 2007-12-31
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Publication Title |
Heterocycles
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Volume | volume74
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Issue | issue1
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Publisher | The Japan Institute of Heterocyclic Chemistry
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Start Page | 983
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End Page | 989
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ISSN | 1881-0942
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Content Type |
Journal Article
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Official Url | http://dx.doi.org/10.3987/COM-07-S(W)45
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language |
English
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Copyright Holders | © The Japan Institute of Heterocyclic Chemistry
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File Version | author
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Refereed |
True
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DOI | |
Web of Science KeyUT | |
Submission Path | organic_chemistry/6
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