このエントリーをはてなブックマークに追加
ID 60250
FullText URL
Author
Watanabe, Takaichi Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID researchmap
Kimura, Yukitaka Department of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University Kaken ID publons
Ono, Tsutomu Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID publons researchmap
Abstract
A simple approach to preparing monodisperse poly(D,L-lactide) (PDLLA) microcapsules with a single aqueous core is developed. The method is based on automatic water-in-oil-in-water double emulsion formation from oil-in-water single emulsion via spontaneous emulsification which voluntarily disperses part of continuous aqueous phase into the dispersed oil phase dissolving oil-soluble amphiphilic diblock copolymer, poly(D,L-lactide)-b-poly(2-dimethylaminoethyl methacylate)(PDLLA-b-PDMAEMA), followed by coalescence of tiny water droplets within the polymer droplets, coupled with quick precipitation of polymers by diluting the emulsion with water. In this study, we have investigated the effect of PDLLA to PDLLA-b-PDMAEMA ratios and flow rates of each solution during preparing the emulsion on the final morphology and the size of the microcapsules. It was found that the polymer blend ratio played a crucial role in determining internal structure of the microcapsules. The microcapsules size decreased with the increment of the flow rate ratios of the continuous phase to the dispersed phase and eventually reached 10 μm, while maintaining narrow size distribution. In addition, we have demonstrated that the microcapsules can encapsulate both hydrophilic and hydrophobic compounds during the formation.
Published Date
2013-12-10
Publication Title
RSC Advances
Volume
volume4
Issue
issue10
Publisher
Royal Society of Chemistry
Start Page
4872
End Page
4877
ISSN
2046-2069
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
File Version
publisher
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1039/C3RA44066D
License
https://creativecommons.org/licenses/by-nc/4.0/