ID | 62836 |
Title Alternative | Biophysical and Biochemical Research of Animal Rhodopsins
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Author |
Kojima, Keiichi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Abstract | Opsins (also called animal rhodopsins) are universal photoreceptive proteins that provide the molecular basis of visual and nonvisual photoreception in animals, including humans. Opsins consist of seven helical a-transmembrane domains and use retinal, a derivative of vitamin A, as a chromophore. In many opsins, light absorption triggers photoisomerization from 11-cis retinal to all-trans retinal, resulting in activation via dynamic structural changes in the protein moiety. Activated opsins stimulate cognate trimeric G proteins to induce signal transduction cascades in cells. Recently, molecular and physiological analyses of diverse opsins have progressively advanced. This review introduces the molecular basis and physiological unctions of opsins. Based on the functions of opsins, I will discuss the potential of opsins as target molecules to treat and prevent visual and nonvisual diseases such as sleep disorder and depression.
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Keywords | rhodopsin
opsin
retinal
G protein coupled receptor
vision
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Published Date | 2021-10-1
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Publication Title |
YAKUGAKU ZASSHI
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Volume | volume141
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Issue | issue10
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Publisher | Pharmaceutical Society of Japan
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Start Page | 1155
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End Page | 1160
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ISSN | 0031-6903
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NCID | AN00284903
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2021 The Pharmaceutical Society of Japan
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.1248/yakushi.21-00144
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