ID | 62448 |
Title Alternative | 立体培養法を利用した疾患微小環境モデルの開発と病態解析
|
FullText URL | |
Author |
Tanaka, Hiroyoshi
Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
|
Abstract | Remarkable progress in our ability to analyze diseased tissue has revolutionized our understanding of disease. From a simplistic understanding of abnormalities in bulk tissue, there is now increasing recognition that the heterogeneous and dynamically evolving disease microenvironment plays a crucial role in disease pathogenesis and progression as well as in the determination of therapeutic response. The disease microenvironment consists of multiple cell types as well as the various factors that these cells secrete. There is now immense interest in treatment strategies that target or modify the abnormal disease microenvironment, and a deeper understanding of the mechanisms that drive the formation, maintenance, and progression of the disease microenvironment is thus necessary. The advent of 3-dimensional (3D) cell culture technology has made possible the reconstitution of the disease microenvironment to a previously unimaginable extent in vitro. As an intermediate between traditional in vitro models based on 2-dimensional (2D) cell culture and in vivo models, 3D models of disease enable the in vitro reconstitution of complex interactions within the disease microenvironment which were unamenable in 2D while simultaneously allowing the mechanistic analysis of these interactions that would be difficult to perform in vivo. This symposium review aims to highlight the promise of using 3D cell culture technology to model and analyze the disease microenvironment using pancreatic cancer as an example.
|
Keywords | 3-dimensional cell culture
disease model
disease microenvironment
|
Note | Symposium Review
|
Published Date | 2021-5-1
|
Publication Title |
YAKUGAKU ZASSHI
|
Volume | volume141
|
Issue | issue5
|
Publisher | Pharmaceutical Society of Japan
|
Start Page | 647
|
End Page | 653
|
ISSN | 0031-6903
|
NCID | AN00284903
|
Content Type |
Journal Article
|
language |
English
|
OAI-PMH Set |
岡山大学
|
Copyright Holders | © 2021 The Pharmaceutical Society of Japan
|
File Version | publisher
|
PubMed ID | |
DOI | |
Related Url | isVersionOf https://doi.org/10.1248/yakushi.20-00219-4
|
Citation | Tanaka HY. [Modeling and Analysis of Disease Microenvironments with 3D Cell Culture Technology]. Yakugaku Zasshi. 2021;141(5):647-653. Japanese. doi: 10.1248/yakushi.20-00219-4. PMID: 33952746.
|