ID | 60100 |
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Author |
Miyazaki, Ikuko
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Kikuoka, Ryo
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Isooka, Nami
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Takeshima, Mika
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Sonobe, Kanau
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Arai, Rei
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Funakoshi, Hidemaru
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Quin, Kyle E.
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Smart, Smart
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Zensho, Kazumasa
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Asanuma, Masato
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Abstract | Bisphenol A diglycidyl ether (BADGE) is an epoxy resin used for the inner coating of canned food and beverages. BADGE can easily migrate from the containers and become a contaminant. In this study, we examined the effects of BADGE exposure to the dams on the behavioral, structural, and developmental abnormalities in the offspring. Female pregnant mice were fed with a diet containing BADGE (0.15 or 1.5 mg/kg/day) during gestation and lactation periods. In an open field test, the time spent in the corner area significantly increases in male mice of high-dose BADGE group at 5 weeks old. The histological analysis using offspring brain at postnatal day 1 delivered from BADGE (1.5 mg/kg/day)-treated dams demonstrates that positive signals of Forkhead box P2- and COUP-TF interacting protein 2 are restricted in each cortical layer, but not in the control brain. In addition, the maternal BADGE exposure reduces nestin-positive fibers of the radial glia and T-box transcription factor 2-positive intermediate progenitors in the inner subventricular zone. Furthermore, a direct BADGE exposure promotes neurite outgrowth and neuronal connection in the primary cultured cortical neurons. These data suggest that maternal BADGE exposure can accelerate neuronal differentiation in fetuses and induce anxiety-like behavior in juvenile mice.
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Keywords | Bisphenol A diglycidyl ether
Epoxy resin
Brain development
Neuronal differentiation
Anxiety behavior
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Note | This fulltext is available in March 2021.
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Published Date | 2020-03-03
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Publication Title |
Food and Chemical Toxicology
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Volume | volume138
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Publisher | Pergamon
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Start Page | 111235
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ISSN | 0278-6915
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NCID | AA10627174
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2020 Elsevier Ltd.
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File Version | author
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Related Url | isVersionOf https://doi.org/10.1016/j.fct.2020.111235
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License | https://creativecommons.org/licenses/by-nc-nd/4.0/
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