ID | 30865 |
JaLCDOI | |
FullText URL | |
Author |
Taguchi, Hirokuni
Miyoshi, Isao
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Abstract | Suppression of the cellular immune system appears to be a prerequisite for the manifestation of adult T-cell leukemia (ATL). In other words, ATL will develop when impairment of the immune system is caused by the infection of human T-lymphotropic virus type I (HTLV-I). This defect of immune surveillance against virus-infected cells may be a result of the impairment of the function of cytotoxic T-cells (CTLs) specific for the HTLV-I-infected cells. The manifestation of ATL could be predicted by examining the function of CTLs in HTLV-I carriers. A new strategy of prevention and therapy for ATL would include an attempt to restore and fortify the CTL function of the host. |
Keywords | immunodeficiency
ATL
HTLV-I carrier
opportunistic infection
malignancy
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Amo Type | Review
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Publication Title |
Acta Medica Okayama
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Published Date | 1989-12
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Volume | volume43
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Issue | issue6
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Publisher | Okayama University Medical School
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Start Page | 317
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End Page | 321
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |