Regional difference in cyclic AMP response to adenosine of rat cerebral cortex with an iron-induced epileptic focus.

A chronic epileptic focus not resulting in generalized convulsions was induced by a microinjection of FeCl3 solution into the left anterior cortex of rats. Cyclic AMP accumulation in response to adenosine was examined in incubated slices from the cerebral cortex of animals that showed bilateral spike and slow wave complex in an electrocorticogram (ECoG) 30 to 60 days after the microinjection. Cyclic AMP accumulation after incubation with adenosine was most marked in slices from the left anterior quadrant of the cortex including a FeCl3-injected site. A medium response was observed in both the left posterior and the right anterior quadrants, but little or no response in the right posterior quadrant of the cortex.