ID | 31015 |
JaLCDOI | |
FullText URL | |
Author |
Takahashi, Isao
Sekito, Noriko
Takeuchi, Makoto
Osada, Ken
Matsuzaki, Toshiro
Fukuda, Shunichi
Lai, Minyu
Uchida, Kozaburo
Kimura, Ikuro
Miyamoto, Kanji
Kitajima, Koichi
Sanada, Hiroshi
|
Abstract | The rearrangement of breakpoint cluster region (ber) was examined in leukemic cells obtained from 3 patients initially diagnosed as having Ph+ acute leukemia, 2 with acute lymphocytic leukemia (ALL) and one with acute mixed leukemia. DNA was digested with Bgl II and BamH I. The ber rearrangement was present in the case of acute mixed leukemia (Case 1), but was absent in the 2 cases of ALL (Cases 2 and 3). These results suggest that Case 1 represented a type of blast crisis of chronic myelocytic leukemia which was unusual in the sense of the occurrence of a myeloid-lymphoid conversion and lack of an apparent chronic phase. Cases 2 and 3 appeared to be de novo Ph+ ALL. |
Keywords | Ph-positive acute leukemia
blast crisis with a silent chronic phase
myeloidlymphoid conversion
chronic myelocytic leukemia
bcr-rearrangement
|
Amo Type | Article
|
Publication Title |
Acta Medica Okayama
|
Published Date | 1988-04
|
Volume | volume42
|
Issue | issue2
|
Publisher | Okayama University Medical School
|
Start Page | 117
|
End Page | 120
|
ISSN | 0386-300X
|
NCID | AA00508441
|
Content Type |
Journal Article
|
language |
English
|
File Version | publisher
|
Refereed |
True
|
PubMed ID | |
Web of Science KeyUT |