ID | 31006 |
JaLCDOI | |
FullText URL | |
Author |
Mukai, Kota
Horimi, Tadashi
Orita, Kunzo
|
Abstract | Eradication of immunologically-syngeneic tumors was achieved by adoptive chemotherapy using effector cells induced by Corynebacterium parvum-Pyridine Extract Residue (CP-PER). A mixture of 2 X 10(6) Meth A cells and 0.1 mg CP-PER was subcutaneously inoculated into the back of donor BALB/c mice, with the result that their spleen cells showed an antitumor effect 10 to 13 days after the inoculation. These cells were used as immune cells. Recipient mice were inoculated with 1 X 10(6) Meth A cells, and 2 days later were administered cyclophosphamide. On the following day, 1 X 10(8) immune cells were adoptively transferred into the recipient mice. As a result, the tumor began to regress 7 to 12 days after the adoptive transfer. An immuno-histochemical study of the donors' spleens and the recipients' regressing tumors revealed that the ratio of L3T4+ T cells to Lyt-2+ T cells in the donors' spleens was increased and that the infiltrating cells in the recipients' tumors were mainly composed of L3T4+ T cells. This confirmed that the transfer of L3T4+ T cells led to the infiltration of L3T4+ T cells into the recipients' tumors, causing their eradication. |
Keywords | eradication of Meth A fibrosarcoma
adoptive immunotherapy
L3T4???lymphocyte
Corynebacterium parvum-Pyridine Extract Residue
|
Amo Type | Article
|
Publication Title |
Acta Medica Okayama
|
Published Date | 1988-12
|
Volume | volume42
|
Issue | issue6
|
Publisher | Okayama University Medical School
|
Start Page | 301
|
End Page | 310
|
ISSN | 0386-300X
|
NCID | AA00508441
|
Content Type |
Journal Article
|
language |
English
|
File Version | publisher
|
Refereed |
True
|
PubMed ID | |
Web of Science KeyUT |