ID | 65750 |
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Author |
Pavlovic, Marko
University Hospital Center Mostar, University of Mostar
Babic, Dragan
University Hospital Center Mostar, University of Mostar
Rastovic, Pejana
University Hospital Center Mostar, University of Mostar
Arapovic, Jurica
University Hospital Center Mostar, University of Mostar
Martinac, Marko
Health Care Center Mostar, University of Mostar
Jakovac, Sanja
University Hospital Center Mostar, University of Mostar
Barbaric, Romana
University Hospital Center Mostar, University of Mostar
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Abstract | We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia.
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Keywords | tumor necrosis factor-alpha
schizophrenia
psychopathology
immune system
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2023-08
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Volume | volume77
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Issue | issue4
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Publisher | Okayama University Medical School
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Start Page | 395
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End Page | 405
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |