ID | 64362 |
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Author |
Katsumata, Ryo
Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center
Manabe, Noriaki
Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School General Medical Center
Monobe, Yasumasa
Pathology, Kawasaki Medical School General Medical Center
Ayaki, Maki
Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School General Medical Center
Suehiro, Mitsuhiko
Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center
Fujita, Minoru
Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School General Medical Center
Kamada, Tomoari
Health Care Medicine, Kawasaki Medical School General Medical Center
Kawamoto, Hirofumi
Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center
Haruma, Ken
Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center
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Abstract | Melanosis coli (MC) is an acquired colorectal disorder visualized as colonic mucosa pigmentation. Disease severity is confirmed based on MC depth, shape, and coloration, although the clinical course is not fully understood. This study sought to clarify characteristics of MC development and disappearance and to investigate its clinical course and severity. Contributors to MC grade progression were explored. This study reviewed MC cases discovered via colonoscopy at a single institution over a 10-year period. Of all 216 MC cases, 17 developing and 10 disappearing cases were detected. Anthranoid laxative use was a key factor: 29.4% of the developing cases had used such agents before the initial MC diagnosis, whereas 40% of disappearing cases had discontinued anthranoids prior to detection of MC disappearance. Among 70 grade I cases, progression to grade II occurred in 16 cases during a mean follow-up of 3.67±2.1 years (rate of progression=22.8%). Males more commonly showed progressive than stable grade I cases, and the probability of progression was higher for male than for female cases. An association between anthranoid administration and MC presence was presumed, and grade I MC was found to progress in severity over 5 years.
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Keywords | melanosis
sex characteristics
laxatives
colorectal neoplasms
colonoscopy
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2023-02
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Volume | volume77
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Issue | issue1
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Publisher | Okayama University Medical School
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Start Page | 57
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End Page | 64
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |