ID | 32845 |
JaLCDOI | |
FullText URL | |
Author |
Niimi, Takashi
Yoshinouchi, Takeo
Ohtsuki, Yuji
Fujita, Jiro
Sato, Shigeki
Sugiura, Yoshiki
Ohta, Kazutaka
Kajiura, Motoharu
Ueda, Ryuzo
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Abstract | Nonspecific interstitial pneumonia (NSIP) has been recognized as a separate histological classification of interstitial lung disease. Similar features are found not only in idiopathic NSIP, but also in NSIP associated with collagen vascular disorder (CVD-NSIP). We examined the clinical symptoms, laboratory findings, and prognosis of 13 cases of idiopathic NSIP and 11 cases of CVD-NSIP. Immunohistochemical staining was performed using the streptavidin/biotin/peroxidase method with anti-alpha-smooth muscle actin antibody. No differences in the distribution of clinical features, laboratory findings, and prognosis were observed between idiopathic NSIP and CVD-NSIP. In immunohistochemical staining of the fibrosing areas, myofibroblasts were observed in 7 of 13 idiopathic NSIP cases, but in 10 of 11 CVD-NSIP cases. With regards to intra-alveolar organization, myofibroblasts were observed in all 10 CVD-NSIP cases, but they were observed in only 2 of 9 idiopathic NSIP cases. We found a significantly higher myofibroblast proliferation in the intra-alveolar organization of CVD-NSIP compared to idiopathic NSIP. Clinically, idiopathic NSIP and CVD-NSIP are similar, but are pathologically different. |
Keywords | interstitial pneumonia
nonspecific interstitial pneumonia
myofibroblast
collagen vascular disorder
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2003-02
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Volume | volume57
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Issue | issue1
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Publisher | Okayama University Medical School
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Start Page | 33
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End Page | 38
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |